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The role of soluble B cell-activating factor in further stratifying the risk of antibody-mediated rejection post-renal transplant: A meta-analysis.

Abstract：

BACKGROUND:We conducted a meta-analysis to evaluate the predictive value of serum soluble B cell-activating factor (sBAFF) for antibody-mediated rejection (ABMR), which remains controversial. METHODS:Systematic literature search was performed in PubMed, EMBASE, Scopus, Cochrane Library, Web of Science and three Chinese databases. Studies of any relevant design were included. Random and fixed-effects meta-analytical models were used. Study quality, publication bias, and heterogeneity were assessed. This study was registered with PROSPERO (CRD42019109198). RESULTS:Nine observational studies were included in the meta-analysis, including 1302 cases (median NOS quality score = 8, range 6-8). The incidence of ABMR was significantly higher in the high sBAFF group than in the low sBAFF level group (Risk ratio [RR] 2.04 [95% CI 1.52-2.74], I2 = 26%, P < 0.01, N = 1014). The subgroup analysis showed that regardless of pre-transplant donor-specific antibody (DSA) status, the high sBAFF level group still had a significantly higher incidence of ABMR. sBAFF was not associated with the risk of TCMR. The sBAFF level was significantly higher in the anti-HLA-antibody (+) group than in anti-HLA-antibody (-) patients before or after kidney transplantation (Standardized mean difference [SMD] 0.43 [0.29-0.56], P < 0.01, I2 = 34%, N = 1001). CONCLUSION:sBAFF is a promising biomarker to further stratify the risk of ABMR post-renal transplant.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Zhang H,Wang S,Su X,Fu Q,Li J,Wang J,Deng R,Wu C,Huang Q,Liu L,Wang C

doi

10.1016/j.intimp.2019.106059

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

106059

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(19)32030-2

journal_volume

79

pub_type

杂志文章,meta分析,评审

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