Magnetic resonance imaging with optical preamplification and detection.

abstract：:Angulin proteins are a group of evolutionally conserved type I transmembrane proteins that contain an extracellular Ig-like domain. In mammals, three angulin proteins have been identified, namely immunoglobulin-like domain containing receptor 1 (ILDR1), immunoglobulin-like domain containing receptor 2 (ILDR2), and lip...

journal_title：Scientific reports

authors： Liu Y,Nie H,Liu C,Zhai X,Sang Q,Wang Y,Shi D,Wang L,Xu Z

更新日期：2017-08-07 00:00:00

abstract：:Endoplasmic reticulum (ER) stress preconditioning protects cells against methylmercury (MeHg) cytotoxicity by inducing integrated stress responses such as eIF2α phosphorylation, ATF4 accumulation, and nonsense-mediated mRNA decay (NMD) suppression. Here we demonstrated that ER stress preconditioning results in the upr...

journal_title：Scientific reports

authors： Usuki F,Fujimura M,Yamashita A

更新日期：2017-09-28 00:00:00

abstract：:The small intestine plays an essential role in the health and well-being of animals. Previous studies have shown that Lactobacillus has a protective effect on intestinal morphology, intestinal epithelium integrity and appropriate maturation of gut-associated tissues. Here, gene expression in jejunum tissue of weaned p...

journal_title：Scientific reports

authors： Zhang D,Shang T,Huang Y,Wang S,Liu H,Wang J,Wang Y,Ji H,Zhang R

更新日期：2017-11-17 00:00:00

abstract：:Metabolomics was applied to a C57BL/6N mouse model of chronic unpredictable mild stress (CMS). Such mice were treated with two antidepressants from different categories: fluoxetine and imipramine. Metabolic profiling of the hippocampus was performed using gas chromatography-mass spectrometry analysis on samples prepar...

journal_title：Scientific reports

authors： Zhao J,Jung YH,Jang CG,Chun KH,Kwon SW,Lee J

更新日期：2015-03-09 00:00:00

abstract：:Detailed structural analyses of the mushroom body which plays critical roles in olfactory learning and memory revealed that it is directly connected with multiple primary sensory centers in Drosophila. Connectivity patterns between the mushroom body and primary sensory centers suggest that each mushroom body lobe proc...

journal_title：Scientific reports

authors： Yagi R,Mabuchi Y,Mizunami M,Tanaka NK

更新日期：2016-07-11 00:00:00

abstract：:CRISPR-Cas9 is a powerful new tool for genome editing, but this technique creates mosaic mutations that affect the efficiency and precision of its ability to edit the genome. Reducing mosaic mutations is particularly important for gene therapy and precision genome editing. Although the mechanisms underlying the CRSIPR...

journal_title：Scientific reports

authors： Tu Z,Yang W,Yan S,Yin A,Gao J,Liu X,Zheng Y,Zheng J,Li Z,Yang S,Li S,Guo X,Li XJ

更新日期：2017-02-03 00:00:00

abstract：:Epigenetic variation is implicated in a range of non-communicable diseases, including those of the eye. However, investigating the role of epigenetic variation in central tissues, such as eye or brain, remains problematic and peripheral tissues are often used as surrogates. In this study, matched human blood and eye t...

journal_title：Scientific reports

authors： Hewitt AW,Januar V,Sexton-Oates A,Joo JE,Franchina M,Wang JJ,Liang H,Craig JE,Saffery R

更新日期：2017-04-13 00:00:00

abstract：:Transcript levels are the primary factor determining protein levels, but for the majority of genes, fold changes in transcript levels are larger than the corresponding changes in protein levels, a phenomenon that is termed "protein homeostasis". However, this phenomenon is not well characterized in the context of envi...

journal_title：Scientific reports

authors： Sun Y,Wen J,Chen R,Deng Y

更新日期：2019-05-24 00:00:00

abstract：:Craniosynostosis must often be corrected using surgery, by which the affected bone tissue is remodeled. Nowadays, surgical reconstruction relies mostly on the subjective judgement of the surgeon to best restore normal skull shape, since remodeled bone is manually placed and fixed. Slight variations can compromise the ...

journal_title：Scientific reports

authors： García-Mato D,Ochandiano S,García-Sevilla M,Navarro-Cuéllar C,Darriba-Allés JV,García-Leal R,Calvo-Haro JA,Pérez-Mañanes R,Salmerón JI,Pascau J

更新日期：2019-11-27 00:00:00

abstract：:Many drugs commonly prescribed during pregnancy lack a fetal safety recommendation - called FDA 'category C' drugs. This study aims to classify these drugs into harmful and safe categories using knowledge gained from chemoinformatics (i.e., pharmacological similarity with drugs of known fetal effect) and empirical dat...

journal_title：Scientific reports

authors： Boland MR,Polubriaginof F,Tatonetti NP

更新日期：2017-10-09 00:00:00

abstract：:Multi-domain voltage-gated ion channels appear to have evolved through sequential rounds of intragenic duplication from a primordial one-domain precursor. Whereas modularity within one-domain symmetrical channels is established, little is known about the roles of individual regions within more complex asymmetrical cha...

journal_title：Scientific reports

authors： Penny CJ,Rahman T,Sula A,Miles AJ,Wallace BA,Patel S

更新日期：2016-12-12 00:00:00

abstract：:Fatty liver (FL) disease is the most common type of chronic liver disease. We hypothesized that liver's response to the process where large droplets of triglyceride fat accumulate in liver cells is reflected also in gene pathway expression in blood. Peripheral blood genome wide gene expression analysis and ultrasonic ...

journal_title：Scientific reports

authors： Taipale T,Seppälä I,Raitoharju E,Mononen N,Lyytikäinen LP,Illig T,Waldenberger M,Juonala M,Hutri-Kähönen N,Oksala N,Kähönen M,Raitakari O,Lehtimäki T

更新日期：2018-07-09 00:00:00

abstract：:Intractable diseases such as cancer are associated with breakdown in multiple individual functions, which conspire to create unhealthy phenotype-combinations. An important challenge is to decipher how these functions are coordinated in health and disease. We approach this by drawing on dynamical systems theory. We pos...

journal_title：Scientific reports

authors： Deritei D,Aird WC,Ercsey-Ravasz M,Regan ER

更新日期：2016-03-16 00:00:00

abstract：:Neurofeedback-guided motor imagery training (NF-MIT) has been suggested as a promising therapy for stroke-induced motor impairment. Whereas much NF-MIT research has aimed at signal processing optimization, the type of sensory feedback given to the participant has received less attention. Often the feedback signal is h...

journal_title：Scientific reports

authors： Braun N,Emkes R,Thorne JD,Debener S

更新日期：2016-11-21 00:00:00

abstract：:Bacteremia caused by MRSA with reduced vancomycin susceptibility (MRSA-RVS) frequently resulted in treatment failure and mortality. The relation of bacterial factors and unfavorable outcomes remains controversial. We retrospectively reviewed clinical data of patients with bacteremia caused by MRSA with vancomycin MIC ...

journal_title：Scientific reports

authors： Yang CC,Sy CL,Huang YC,Shie SS,Shu JC,Hsieh PH,Hsiao CH,Chen CJ

更新日期：2018-05-18 00:00:00

abstract：:The S385Y/D469T/R520Q variant of E. coli transketolase was evolved previously with three successive smart libraries, each guided by different structural, bioinformatical or computational methods. Substrate-walking progressively shifted the target acceptor substrate from phosphorylated aldehydes, towards a non-phosphor...

journal_title：Scientific reports

authors： Affaticati PE,Dai SB,Payongsri P,Hailes HC,Tittmann K,Dalby PA

更新日期：2016-10-21 00:00:00

abstract：:2,5-Dimethylfuran (DMF) is a type of attractive sustainable green energy for diesel engines that is designed to reduce soot emission. This study investigated the effect of fuel properties on the macroscopic and microscopic spray characteristics of four test blends under injection pressures of 90, 120 and 150 MPa and a...

journal_title：Scientific reports

authors： Zhang P,Su X,Chen H,Geng L,Zhao X

更新日期：2020-01-29 00:00:00

abstract：:As a two-dimensional material, graphene has attracted increasing attention as heat dissipation material owing to its excellent thermal transport property. In this work, we fabricated sisal nanocrystalline cellulose/functionalized graphene papers (NPGs) with high thermal conductivity by vacuum-assisted self-assembly me...

journal_title：Scientific reports

authors： Ren L,Wang M,Lu S,Pan L,Xiong Z,Zhang Z,Peng Q,Li Y,Yu J

更新日期：2019-03-14 00:00:00

abstract：:Homocysteine (Hcy) has been shown to have a neurotoxic effect on ischemic brain cells; however, the underlying mechanisms remain incompletely understood. Here, we examined whether Hcy treatment influences mitochondria injury, oxidative stress, and mitochondrial STAT3 (mitoStat3) expression in rat ischemic brain. Our r...

journal_title：Scientific reports

authors： Chen S,Dong Z,Zhao Y,Sai N,Wang X,Liu H,Huang G,Zhang X

更新日期：2017-07-31 00:00:00

abstract：:In general, the poultry industry uses 0.5-1 ppm chlorine solution in the meat sanitization process. However, chlorine can react with organic material and produce halogenated organic compounds, notably chloroform, which causes bladder and rectal cancer in humans. For this reason, many industries try to avoid chlorine. ...

journal_title：Scientific reports

authors： Royintarat T,Choi EH,Boonyawan D,Seesuriyachan P,Wattanutchariya W

更新日期：2020-01-31 00:00:00

abstract：:Dramatic functional changes of enzyme usually require scores of alterations in amino acid sequence. However, in the case of guanylate kinase (GK), the functional novelty is induced by a single (S→P) mutation, leading to the functional transition of the enzyme from a phosphoryl transfer kinase into a phosphorprotein in...

journal_title：Scientific reports

authors： Zhang Y,Niu H,Li Y,Chu H,Shen H,Zhang D,Li G

更新日期：2015-02-12 00:00:00

abstract：:Hepatitis B Virus (HBV) replication in hepatocytes is restricted by the host innate immune system and related intracellular signaling pathways. Transforming growth factor β-activated kinase 1 (TAK1) is a key mediator of toll-like receptors and pro-inflammatory cytokine signaling pathways. Here, we report that silencin...

journal_title：Scientific reports

authors： Pang J,Zhang G,Lin Y,Xie Z,Liu H,Tang L,Lu M,Yan R,Guo H,Sun J,Hou J,Zhang X

更新日期：2017-01-03 00:00:00

abstract：:Recent studies showed that anomalous dry conditions and limited moisture supply roughly between 1998 and 2008, especially in the Southern Hemisphere, led to reduced vegetation productivity and ceased growth in land evapotranspiration (ET). However, natural variability of Earth's climate system can degrade capabilities...

journal_title：Scientific reports

authors： Zhang K,Kimball JS,Nemani RR,Running SW,Hong Y,Gourley JJ,Yu Z

更新日期：2015-10-30 00:00:00

abstract：:(R-)miniCHOP therapy, which delivers approximately half-doses of the (R-)CHOP regimen, has shown efficacy and safety in patients who are more than 80 years old. This study aimed to compare the area under the plasma concentration-time curves (AUCs) of vincristine (VCR), doxorubicin (DXR), and cyclophosphamide (CPA) bet...

journal_title：Scientific reports

authors： Nakagawa J,Takahata T,Hyodo R,Chen Y,Hasui K,Sasaki K,Saito K,Ueno K,Hosoi K,Terui K,Sato A,Niioka T

更新日期：2021-01-12 00:00:00

abstract：:Inflammatory reactions activated by pattern recognition receptors (PRRs) on the membrane of innate immune cells play an important role in atherosclerosis. Whether the PRRs of the C-type lectin receptor (CLR) family including Dectin-2 may be involved in the pathogenesis of atherosclerosis remains largely unknown. Recen...

journal_title：Scientific reports

authors： Thiem K,Hoeke G,van den Berg S,Hijmans A,Jacobs CWM,Zhou E,Mol IM,Mouktaroudi M,Bussink J,Kanneganti TD,Lutgens E,Stienstra R,Tack CJ,Netea MG,Rensen PCN,Berbée JFP,van Diepen JA

更新日期：2019-03-13 00:00:00

abstract：:Natural killer (NK) cells are essential for immunosurveillance against transformed cells. Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channel gated by ADP-ribose (ADPR). However, the role of TRPM2-mediated Ca(2+) signaling in the antitumor response of NK cells has not been explored. ...

journal_title：Scientific reports

authors： Rah SY,Kwak JY,Chung YJ,Kim UH

更新日期：2015-03-25 00:00:00

abstract：:Particles manipulation with optical forces is known as optical tweezing. While tweezing in free space with laser beams was established in the 1980s, integrating the optical tweezers on a chip is a challenging task. Recent experiments with plasmonic nanoantennas, microring resonators, and photonic crystal nanocavities ...

journal_title：Scientific reports

authors： Renaut C,Cluzel B,Dellinger J,Lalouat L,Picard E,Peyrade D,Hadji E,de Fornel F

更新日期：2013-01-01 00:00:00

abstract：:It is now well established that invasive plants may induce drifts in the quantity and/or quality of floral resources. They are then often pointed out as a potential driver of bee decline. However, their impact on bee population remains quite unclear and still controversial, as bee responses are highly variable among s...

journal_title：Scientific reports

authors： Drossart M,Michez D,Vanderplanck M

更新日期：2017-11-24 00:00:00

abstract：:Commercial Pt/C anodes of direct formic acid fuel cells (DFAFCs) get rapidly poisoned by in-situ generated CO intermediates from formic acid non-faradaic dissociation. We succeeded in increasing the Pt nanoparticles (PtNPs) stability and activity for formic acid oxidation (DFAFCs anodic reaction) by embedding them ins...

journal_title：Scientific reports

authors： El-Nagar GA,Hassan MA,Lauermann I,Roth C

更新日期：2017-12-19 00:00:00

abstract：:Neuroblastoma is the most common and deadly childhood tumor. Relapsed or refractory neuroblastoma has a very poor prognosis despite recent treatment advances. To investigate genomic alterations associated with relapse and therapy resistance, whole-genome sequencing was performed on diagnostic and relapsed lesions toge...

journal_title：Scientific reports

authors： Fransson S,Martinez-Monleon A,Johansson M,Sjöberg RM,Björklund C,Ljungman G,Ek T,Kogner P,Martinsson T

更新日期：2020-12-31 00:00:00