Abstract:
:Bacteremia caused by MRSA with reduced vancomycin susceptibility (MRSA-RVS) frequently resulted in treatment failure and mortality. The relation of bacterial factors and unfavorable outcomes remains controversial. We retrospectively reviewed clinical data of patients with bacteremia caused by MRSA with vancomycin MIC = 2 mg/L from 2009 to 2012. The significance of bacterial genotypes, agr function and heterogeneous vancomycin-intermediate S. aureus (hIVSA) phenotype in predicting outcomes were determined after clinical covariates adjustment with multivariate analysis. A total of 147 patients with mean age of 63.5 (±18.1) years were included. Seventy-nine (53.7%) patients failed treatment. Forty-seven (31.9%) patients died within 30 days of onset of MRSA bacteremia. The Charlson index, Pitt bacteremia score and definitive antibiotic regimen were independent factors significantly associated with either treatment failure or mortality. The hVISA phenotype was a potential risk factor predicting treatment failure (adjusted odds ratio 2.420, 95% confidence interval 0.946-6.191, P = 0.0652). No bacterial factors were significantly associated with 30-day mortality. In conclusion, the comorbidities, disease severity and antibiotic regimen remained the most relevant factors predicting treatment failure and 30-day mortality in patients with MRSA-RVS bacteremia. hIVSA phenotype was the only bacterial factor potentially associated with unfavorable outcome in this cohort.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Yang CC,Sy CL,Huang YC,Shie SS,Shu JC,Hsieh PH,Hsiao CH,Chen CJdoi
10.1038/s41598-018-26277-9subject
Has Abstractpub_date
2018-05-18 00:00:00pages
7868issue
1issn
2045-2322pii
10.1038/s41598-018-26277-9journal_volume
8pub_type
杂志文章abstract::c-FLIP (cellular FLICE-inhibitory protein) is the pivotal regulator of TRAIL resistance in cancer cells, It is a short-lived protein degraded through the ubiquitin/proteasome pathway. The discovery of factors and mechanisms regulating its protein stability is important for the comprehension of TRAIL resistance by tumo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22999
更新日期:2016-03-14 00:00:00
abstract::Antimicrobial resistance seriously threatened human health. Combination therapy is generally an effective strategy to fight resistance, while some data on its effects are conflicting. To explore the reasons, the fractional inhibitory concentration indexes (FICIs) of three designed combinations against methicillin-resi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25714-z
更新日期:2018-05-08 00:00:00
abstract::Given a reaction-diffusion system interacting via a complex network, we propose two different techniques to modify the network topology while preserving its dynamical behaviour. In the region of parameters where the homogeneous solution gets spontaneously destabilized, perturbations grow along the unstable directions ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34372-0
更新日期:2018-11-01 00:00:00
abstract::The spreading of invasive species in new continents can vary from slow and limited diffusion to fast colonisations over vast new areas. We studied the sacred ibis Threskiornis aethiopicus along a 31-year period, from 1989 to 2019, with particular attention to the first area of release in NW Italy. We collected data on...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79137-w
更新日期:2021-01-08 00:00:00
abstract::Many basic properties of the T-cell receptor (TCR) repertoire require clarification, and the changes occurring in the TCR repertoire during carcinogenesis, especially during precancerous stages, remain unclear. This study used deep sequencing analyses to examine 41 gastric tissue samples at different pathological stag...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08289-z
更新日期:2017-08-10 00:00:00
abstract::DDX3, a subunit of CK1ε, phosphorylates Dvl2 to promote β-catenin activation. Overexpression of the Dvl2 protein results in potent activation of β-catenin/TCF signaling in colorectal cancer. Therefore, we hypothesized that DDX3 might promote tumor invasion via the CK1ε/Dvl2 axis due to β-catenin/TCF activation. Wester...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21483
更新日期:2016-02-19 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-57833-x
更新日期:2020-01-15 00:00:00
abstract::Our study focused on quantifying the alterations of streamflow at a weir site due to the construction of a mini-hydropower plant in the Gurugoda Oya (Sri Lanka), and evaluating the spatial responses of benthic macroinvertebrates to altered flow regime. The HEC-HMS 3.5 model was applied to the Gurugoda Oya sub-catchmen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79576-5
更新日期:2021-01-12 00:00:00
abstract::Global climate change (GCC) can negatively affect freshwater ecosystems. However, the degree to which freshwater populations can acclimate to long-term warming and the underlying molecular mechanisms are not yet fully understood. We used the cooling water discharge (CWD) area of a power plant as a model for long-term ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39476
更新日期:2016-12-20 00:00:00
abstract::Large amounts of anthropogenic CO2 in the atmosphere are taken up by the ocean, which leads to 'ocean acidification' (OA). In addition, the increasing application of nanoparticles inevitably leads to their increased release into the aquatic environment. However, the impact of OA on the bioaccumulation of nanoparticles...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40047-1
更新日期:2019-03-05 00:00:00
abstract::On an SiO2-patterned c-plane sapphire substrate, GaN domains were grown with their polarity controlled in accordance with the pattern. While N-polar GaN was grown on hexagonally arranged circular openings, Ga-polar GaN was laterally overgrown on mask regions due to polarity inversion occurring at the boundary of the c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22424-4
更新日期:2018-03-07 00:00:00
abstract::Secondary ion mass spectrometry is an excellent technique of analytical chemistry, where primary ions sputter a solid sample generating the secondary ions which are determined. Although the ion yield is inherently low, it can be enhanced by using a post-ionization of sputtered neutral species. Our novel approach integ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06562-9
更新日期:2017-07-20 00:00:00
abstract::The impact of HULC rs7763881 on colorectal cancer (CRC) susceptibility is not yet known. Also, the biological function of the cancer-related rs6983267 remains unclear. We investigated the association of these SNPs with the risk of CRC and adenomatous polyps (AP), their correlation with CCAT2 and HULC expression, and t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16500-4
更新日期:2017-11-24 00:00:00
abstract::Developing immunoassay for absolute quantitation of protein biomarkers in Formalin Fixed Paraffin Embedded (FFPE) samples promises improved objectivity, consistency and accuracy in daily clinical practice. The feasibility of Quantitative Dot Blot (QDB) method for this purpose was explored in this study. We were able t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69471-4
更新日期:2020-07-27 00:00:00
abstract::The widely accepted multiple-hit hypothesis of carcinogenesis states that cancers arise after several successive events. However, no consensus has been reached on the quantity and nature of these events, although "driver" mutations or epimutations are considered the most probable candidates. By using the largest publi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12448-7
更新日期:2017-09-22 00:00:00
abstract::Quantum Zeno effect shows that frequent observations can slow down or even stop the unitary time evolution of an unstable quantum system. This effect can also be regarded as a physical consequence of the statistical indistinguishability of neighboring quantum states. The accessibility of quantum Zeno dynamics under un...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11509
更新日期:2015-06-23 00:00:00
abstract::Searching, defined for the purpose of the present study as the displacement of an individual to locate resources, is a fundamental behavior of all mobile organisms. In humans this behavior underlies many aspects of everyday life, involving cognitive processes such as sustained attention, memory and inhibition. We expl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19664
更新日期:2016-01-25 00:00:00
abstract::We estimated the prevalence of anemia among school children and investigated factors associated with this problem in Kuwait. A cross-sectional study was conducted on 1415 adolescents randomly selected from middle schools in Kuwait. Hemoglobin, iron, ferritin, folate and vitamin B12, in addition to many other laborator...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60816-7
更新日期:2020-04-03 00:00:00
abstract::The success of mesenchymal stem cell transplantation is highly dependent on their survival and controlled fate regulation. This study demonstrates that dual-delivery of connective tissue growth factor (CTGF) and fibroblast growth factor 2 (FGF-2) from a core-shell fiber of Silk Fibroin/poly(L-lactic acid-co-ε-caprolac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08226-0
更新日期:2017-08-17 00:00:00
abstract::The small intestine plays an essential role in the health and well-being of animals. Previous studies have shown that Lactobacillus has a protective effect on intestinal morphology, intestinal epithelium integrity and appropriate maturation of gut-associated tissues. Here, gene expression in jejunum tissue of weaned p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16158-y
更新日期:2017-11-17 00:00:00
abstract::We present a proposal to realize the quantum Zeno effect (QZE) and quantum Zeno-like effect (QZLE) in a proximal (13)C nuclear spin by controlling a proximal electron spin of a nitrogen vacancy (NV) center. The measurement is performed by applying a microwave pulse to induce the transition between different electronic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17615
更新日期:2015-12-01 00:00:00
abstract::In inflammatory bowel disease (IBD), compromised restitution of the epithelial barrier contributes to disease severity. Owing to the complexity in the pathogenesis of IBD, a variety of factors have been implicated in its progress. In this study, we report a functional interaction between macroautophagy and Corticotrop...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23342
更新日期:2016-03-18 00:00:00
abstract::Adult-onset vitelliform macular dystrophy (AVMD) is a common and benign macular degeneration which can be caused by BEST1 mutation. Here, we investigated the clinical characteristics associated with a newly identified BEST1 mutation, p.Ile38Ser and confirmed the associated physiological functional defects. The 51-year...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09629-9
更新日期:2017-08-22 00:00:00
abstract::We aimed to model longitudinal data to create predictive growth charts for weight in preterm infants from birth till discharge, that took into account the differing growth rates post-birth when compared to in-utero growth and therefore was more representative of the data than the UK1990 reference charts. Data from bir...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60895-6
更新日期:2020-03-04 00:00:00
abstract::Inter-digital capacitors (IDCs) with aerosol-deposition (AD) high-k dielectric layer were compared via simulation and measurements of bare IDCs and AD IDCs at room temperature and subjected to a post-annealing process for realizing capacitive super-sensing applications. IDCs with thin AD films can provide higher capac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37416-7
更新日期:2019-01-24 00:00:00
abstract::Although vitamin K deficiency has been implicated in adult inflammatory bowel disease (IBD), its prevalence in pediatric IBD remains unknown. We carried out a cross-sectional study in 63 children with Crohn's disease (CD) and 48 with ulcerative colitis (UC) to assess the prevalence of vitamin K deficiency and to searc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04768
更新日期:2014-04-24 00:00:00
abstract::Singular beams which possess helical phase wavefront or spatially inhomogeneous polarization provide new freedom for optical field manipulation. However, conventional schemes to produce the singular beams have difficulty in realizing the flexible switch between different singular beams. In this work, we have experimen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07217-5
更新日期:2017-07-28 00:00:00
abstract::Studies of tumor models using syngeneic transplantation have advanced our understanding of tumor immunity, including both immune surveillance and evasion. Murine mammary carcinoma 4T1 cells secrete immunosuppressive soluble factors as demonstrated in splenocyte culture. Cultured primary splenocytes secrete IFN-γ, whic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08913
更新日期:2015-03-09 00:00:00
abstract::Angiogenin (hANG), a member of the Ribonuclease A superfamily has angiogenic, neurotrophic and neuroprotective activities. Mutations in hANG have been found in patients with Amyotrophic lateral sclerosis (ALS). The zebrafish (Danio rerio) rnasel-1, 2 and 3 are orthologues of hANG and of these only Rnasel-1 and Rnasel-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37140-2
更新日期:2019-02-01 00:00:00
abstract::Concurrent chemoradiation therapy (CCRT) is the treatment of choice for locally advanced non-small cell lung cancer (LA-NSCLC). Several clinical trials that combine programmed cell death 1 (PD-1) axis inhibitors with radiotherapy are in development for patients with LA-NSCLC. However, the effect of CCRT on programmed ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11949-9
更新日期:2017-09-12 00:00:00