Enhanced and unified anatomical labeling for a common mouse brain atlas.

abstract：:The cost, size and availability of electron accelerators are dominated by the achievable accelerating gradient. Conventional high-brightness radio-frequency accelerating structures operate with 30-50 MeV m(-1) gradients. Electron accelerators driven with optical or infrared sources have demonstrated accelerating gradi...

journal_title：Nature communications

authors： Nanni EA,Huang WR,Hong KH,Ravi K,Fallahi A,Moriena G,Miller RJ,Kärtner FX

更新日期：2015-10-06 00:00:00

abstract：:Secondary multidrug transporters use ion concentration gradients to energize the removal from cells of various antibiotics. The Escherichia coli multidrug transporter MdfA exchanges a single proton with a single monovalent cationic drug molecule. This stoichiometry renders the efflux of divalent cationic drugs energet...

journal_title：Nature communications

authors： Fluman N,Adler J,Rotenberg SA,Brown MH,Bibi E

更新日期：2014-08-08 00:00:00

abstract：:Oscillatory synchrony among neurons occurs in many species and brain areas, and has been proposed to help neural circuits process information. One hypothesis states that oscillatory input creates cyclic integration windows: specific times in each oscillatory cycle when postsynaptic neurons become especially responsive...

journal_title：Nature communications

authors： Gupta N,Singh SS,Stopfer M

更新日期：2016-12-15 00:00:00

abstract：:Gene deletion-induced autophagy deficiency leads to neural tube defects (NTDs), similar to those in diabetic pregnancy. Here we report the key autophagy regulators modulated by diabetes in the murine developing neuroepithelium. Diabetes predominantly leads to exencephaly, induces neuroepithelial cell apoptosis and sup...

journal_title：Nature communications

authors： Wang F,Xu C,Reece EA,Li X,Wu Y,Harman C,Yu J,Dong D,Wang C,Yang P,Zhong J,Yang P

更新日期：2017-05-05 00:00:00

abstract：:HIV infection causes bone loss. We previously reported that immunosuppression-mediated B-cell production of receptor activator of NF-κB ligand (RANKL) coupled with decline in osteoprotegerin correlate with decreased bone mineral density (BMD) in untreated HIV infection. Paradoxically, antiretroviral therapy (ART) wors...

journal_title：Nature communications

authors： Ofotokun I,Titanji K,Vikulina T,Roser-Page S,Yamaguchi M,Zayzafoon M,Williams IR,Weitzmann MN

更新日期：2015-09-22 00:00:00

abstract：:Natural products have traditionally been rich sources for drug discovery. In order to clear the road toward the discovery of unknown natural products, biologists need dereplication strategies that identify known ones. Here we report DEREPLICATOR+, an algorithm that improves on the previous approaches for identifying p...

journal_title：Nature communications

authors： Mohimani H,Gurevich A,Shlemov A,Mikheenko A,Korobeynikov A,Cao L,Shcherbin E,Nothias LF,Dorrestein PC,Pevzner PA

更新日期：2018-10-02 00:00:00

abstract：:Development of effective antimicrobial agents continues to be a great challenge, particularly due to the increasing resistance of superbugs and frequent hospital breakouts. There is an urgent need for more potent and safer antibiotics with novel scaffolds. As historically many commercial drugs were derived from natura...

journal_title：Nature communications

authors： Lin Z,Xu X,Zhao S,Yang X,Guo J,Zhang Q,Jing C,Chen S,He Y

更新日期：2018-09-04 00:00:00

abstract：:Copper levels are known to be elevated in inflamed and malignant tissues. But the mechanism underlying this selective enrichment has been elusive. In this study, we report a axis by which inflammatory cytokines, such as IL-17, drive cellular copper uptake via the induction of a metalloreductase, STEAP4. IL-17-induced ...

journal_title：Nature communications

authors： Liao Y,Zhao J,Bulek K,Tang F,Chen X,Cai G,Jia S,Fox PL,Huang E,Pizarro TT,Kalady MF,Jackson MW,Bao S,Sen GC,Stark GR,Chang CJ,Li X

更新日期：2020-02-14 00:00:00

abstract：:The identification of causal variants in sequencing studies remains a considerable challenge that can be partially addressed by new gene-specific knowledge. Here, we integrate measures of how essential a gene is to supporting life, as inferred from viability and phenotyping screens performed on knockout mice by the In...

journal_title：Nature communications

authors： Cacheiro P,Muñoz-Fuentes V,Murray SA,Dickinson ME,Bucan M,Nutter LMJ,Peterson KA,Haselimashhadi H,Flenniken AM,Morgan H,Westerberg H,Konopka T,Hsu CW,Christiansen A,Lanza DG,Beaudet AL,Heaney JD,Fuchs H,Gailus-Durner

更新日期：2020-01-31 00:00:00

abstract：:Chromatin remodeling is of crucial importance during brain development. Pathogenic alterations of several chromatin remodeling ATPases have been implicated in neurodevelopmental disorders. We describe an index case with a de novo missense mutation in CHD3, identified during whole genome sequencing of a cohort of child...

journal_title：Nature communications

authors： Snijders Blok L,Rousseau J,Twist J,Ehresmann S,Takaku M,Venselaar H,Rodan LH,Nowak CB,Douglas J,Swoboda KJ,Steeves MA,Sahai I,Stumpel CTRM,Stegmann APA,Wheeler P,Willing M,Fiala E,Kochhar A,Gibson WT,Cohen ASA,Agb

更新日期：2018-11-05 00:00:00

abstract：:Tumour-associated macrophages (TAMs) play an important role in tumour progression, which is facilitated by their ability to respond to environmental cues. Here we report, using murine models of breast cancer, that TAMs expressing fibroblast activation protein alpha (FAP) and haem oxygenase-1 (HO-1), which are also fou...

journal_title：Nature communications

authors： Muliaditan T,Caron J,Okesola M,Opzoomer JW,Kosti P,Georgouli M,Gordon P,Lall S,Kuzeva DM,Pedro L,Shields JD,Gillett CE,Diebold SS,Sanz-Moreno V,Ng T,Hoste E,Arnold JN

更新日期：2018-07-27 00:00:00

abstract：:Free-electron lasers providing ultra-short high-brightness pulses of X-ray radiation have great potential for a wide impact on science, and are a critical element for unravelling the structural dynamics of matter. To fully harness this potential, we must accurately know the X-ray properties: intensity, spectrum and te...

journal_title：Nature communications

authors： Sanchez-Gonzalez A,Micaelli P,Olivier C,Barillot TR,Ilchen M,Lutman AA,Marinelli A,Maxwell T,Achner A,Agåker M,Berrah N,Bostedt C,Bozek JD,Buck J,Bucksbaum PH,Montero SC,Cooper B,Cryan JP,Dong M,Feifel R,Frasinski

更新日期：2017-06-05 00:00:00

abstract：:Cholesterol is a key component of cell membranes with a proven modulatory role on the function and ligand-binding properties of G-protein-coupled receptors (GPCRs). Crystal structures of prototypical GPCRs such as the adenosine A2A receptor (A2AR) have confirmed that cholesterol finds stable binding sites at the recep...

journal_title：Nature communications

authors： Guixà-González R,Albasanz JL,Rodriguez-Espigares I,Pastor M,Sanz F,Martí-Solano M,Manna M,Martinez-Seara H,Hildebrand PW,Martín M,Selent J

更新日期：2017-02-21 00:00:00

abstract：:The spikelet is the basal unit of inflorescence in grasses, and its formation is crucial for reproductive success and cereal yield. Here, we report a previously unknown role of the plant hormone jasmonic acid (JA) in determining rice (Oryza sativa) spikelet morphogenesis. The extra glume 1 (eg1) and eg2 mutants exhibi...

journal_title：Nature communications

authors： Cai Q,Yuan Z,Chen M,Yin C,Luo Z,Zhao X,Liang W,Hu J,Zhang D

更新日期：2014-03-19 00:00:00

abstract：:ASXL2 is frequently mutated in acute myeloid leukaemia patients with t(8;21). However, the roles of ASXL2 in normal haematopoiesis and the pathogenesis of myeloid malignancies remain unknown. Here we show that deletion of Asxl2 in mice leads to the development of myelodysplastic syndrome (MDS)-like disease. Asxl2-/- m...

journal_title：Nature communications

authors： Li J,He F,Zhang P,Chen S,Shi H,Sun Y,Guo Y,Yang H,Man N,Greenblatt S,Li Z,Guo Z,Zhou Y,Wang L,Morey L,Williams S,Chen X,Wang QT,Nimer SD,Yu P,Wang QF,Xu M,Yang FC

更新日期：2017-06-08 00:00:00

abstract：:Recent years have seen great advances in the development of synthetic self-assembling molecular systems. Designing out-of-equilibrium architectures, however, requires a more subtle control over the thermodynamics and kinetics of reactions. We propose a mechanism for enhancing the thermodynamic drive of DNA strand-disp...

journal_title：Nature communications

authors： Haley NEC,Ouldridge TE,Mullor Ruiz I,Geraldini A,Louis AA,Bath J,Turberfield AJ

更新日期：2020-05-22 00:00:00

abstract：:Human pre-implantation embryonic development involves extensive changes in chromatin structure and transcriptional activity. Here, we report on LiCAT-seq, a technique that enables simultaneous profiling of chromatin accessibility and gene expression with ultra-low input of cells, and map the chromatin accessibility an...

journal_title：Nature communications

authors： Liu L,Leng L,Liu C,Lu C,Yuan Y,Wu L,Gong F,Zhang S,Wei X,Wang M,Zhao L,Hu L,Wang J,Yang H,Zhu S,Chen F,Lu G,Shang Z,Lin G

更新日期：2019-01-21 00:00:00

abstract：:Crystalline phase transitions caused by external stimuli have been used to detect physical changes in the solid-state properties. This study presents the mechanical switching of crystals of ferrocene-containing rotaxane controlled by focused laser light. The expansion and contraction of the crystals can be driven by t...

journal_title：Nature communications

authors： Chen KJ,Tsai YC,Suzaki Y,Osakada K,Miura A,Horie M

更新日期：2016-11-03 00:00:00

abstract：:The original version of this Article omitted a declaration from the Competing Interests statement, which should have included the following: 'A patent has been applied for by Emory University with F.E.L, I.S. and D.C. N. as named inventors. The patent application number is PCT/US2016/036650'. This has now been correct...

journal_title：Nature communications

authors： Nguyen DC,Garimalla S,Xiao H,Kyu S,Albizua I,Galipeau J,Chiang KY,Waller EK,Wu R,Gibson G,Roberson J,Lund FE,Randall TD,Sanz I,Lee FE

更新日期：2019-01-17 00:00:00

abstract：:Nanostructured metasurfaces offer unique capabilities for subwavelength control of optical waves. Based on this potential, a large number of metasurfaces have been proposed recently as alternatives to standard optical elements. In most cases, however, these elements suffer from large chromatic aberrations, thus limiti...

journal_title：Nature communications

authors： Avayu O,Almeida E,Prior Y,Ellenbogen T

更新日期：2017-04-05 00:00:00

abstract：:Interactions between proteins play an essential role in metabolic and signaling pathways, cellular processes and organismal systems. We report the development of splitFAST, a fluorescence complementation system for the visualization of transient protein-protein interactions in living cells. Engineered from the fluorog...

journal_title：Nature communications

authors： Tebo AG,Gautier A

更新日期：2019-06-27 00:00:00

abstract：:Heterogeneous catalysis is an enabling technology that utilises transition metal nanoparticles (NPs) supported on oxides to promote chemical reactions. Structural mismatch at the NP-support interface generates lattice strain that could affect catalytic properties. However, detailed knowledge about strain in supported ...

journal_title：Nature communications

authors： Nilsson Pingel T,Jørgensen M,Yankovich AB,Grönbeck H,Olsson E

更新日期：2018-07-13 00:00:00

abstract：:For a cell to move forward it must convert chemical energy into mechanical propulsion. Force produced by actin polymerization can generate traction across the plasma membrane by transmission through integrins to their ligands. However, the role this force plays in integrin activation is unknown. Here we show that inte...

journal_title：Nature communications

authors： Nordenfelt P,Elliott HL,Springer TA

更新日期：2016-10-10 00:00:00

abstract：:Fluctuations in glacier motion are very common and are thought to be controlled by subglacial hydrology and till deformation. There are few instrumented studies that have monitored seasonal changes. We use the innovative Glacsweb subglacial in situ wireless probes, combined with dGPS and custom geophone data from an I...

journal_title：Nature communications

authors： Hart JK,Martinez K,Basford PJ,Clayton AI,Robson BA,Young DS

更新日期：2019-04-08 00:00:00

abstract：:Arriving rapidly to the hospital after a heart attack or stroke is critical for patients to be within time windows for treatment. Prior research in heart attacks has suggested a paradoxical role of the social environment: those who arrive early are surrounded by nonrelatives, while those who arrive late are surrounded...

journal_title：Nature communications

authors： Dhand A,Luke D,Lang C,Tsiaklides M,Feske S,Lee JM

更新日期：2019-03-14 00:00:00

abstract：:Drought comprehensively affects different interlinked aspects of the terrestrial water cycle, which have so far been mostly investigated without direct comparison. Resolving the partitioning of water deficit during drought into blue-water runoff and green-water evapotranspiration fluxes is critical, as anomalies in th...

journal_title：Nature communications

authors： Orth R,Destouni G

更新日期：2018-09-06 00:00:00

abstract：:A long-standing and profound problem in astronomy is the difficulty in obtaining deep near-infrared observations due to the extreme brightness and variability of the night sky at these wavelengths. A solution to this problem is crucial if we are to obtain the deepest possible observations of the early Universe, as red...

journal_title：Nature communications

authors： Bland-Hawthorn J,Ellis SC,Leon-Saval SG,Haynes R,Roth MM,Löhmannsröben HG,Horton AJ,Cuby JG,Birks TA,Lawrence JS,Gillingham P,Ryder SD,Trinh C

更新日期：2011-12-06 00:00:00

abstract：:Solitary, persistent wave packets called solitons hold potential to transfer information and energy across a wide range of spatial and temporal scales in physical, chemical, and biological systems. Mechanical solitons characteristically emerge either as a single wave packet or uncorrelated propagating topological enti...

journal_title：Nature communications

authors： Zhang Y,Li B,Zheng QS,Genin GM,Chen CQ

更新日期：2019-12-06 00:00:00

abstract：:Sclerosing stromal tumor (SST) of the ovary is a rare type of sex cord-stromal tumor (SCST), whose genetic underpinning is currently unknown. Here, using whole-exome, targeted capture and RNA-sequencing, we report recurrent FHL2-GLI2 fusion genes in 65% (17/26) of SSTs and other GLI2 rearrangements in additional 15% (...

journal_title：Nature communications

authors： Kim SH,Da Cruz Paula A,Basili T,Dopeso H,Bi R,Pareja F,da Silva EM,Gularte-Mérida R,Sun Z,Fujisawa S,Smith CG,Ferrando L,Martins Sebastião AP,Bykov Y,Li A,Silveira C,Ashley CW,Stylianou A,Selenica P,Samore WR,Jung

更新日期：2020-01-02 00:00:00

abstract：:Exosomes are nanometer-sized lipid vesicles present in liquid biopsies and used as biomarkers for several diseases including cancer, Alzheimer's, and central nervous system diseases. Purification and subsequent size and surface characterization are essential to exosome-based diagnostics. Sample purification is, howeve...

journal_title：Nature communications

authors： Rasmussen MK,Pedersen JN,Marie R

更新日期：2020-05-11 00:00:00