Ameliorative effect of rosiglitazone, a peroxisome proliferator gamma agonist on adriamycin-induced cardio toxicity via suppressing oxidative stress and apoptosis.

abstract：:How cells regulate Gq efficacy (initiation and termination of Gq signaling) to effect response remains a central question in pharmacology and drug discovery. Phospholipase C-β1 (PLC-β1) is an effector and a GTPase activating protein (GAP) specific to Gαq. The physiological function of PLC-β1 GAP remains unclear and co...

journal_title：IUBMB life

authors： Litosch I

更新日期：2013-11-01 00:00:00

abstract：:Calcineurin (CN) is the only serine/threonine specific protein phosphatase regulated by Ca(2+) /calmodulin (CaM), which is composed of catalytic A subunit (CNA) and regulatory B subunit (CNB). Tumor necrosis factor (TNF) receptor associated factor 3 (TRAF3) is an essential component in the Toll like receptors and TNF ...

journal_title：IUBMB life

authors： Wang X,Huang Y,Li L,Wei Q

更新日期：2012-09-01 00:00:00

abstract：:Large inter-individual variation exists in the response to vitamin E supplementation, and this may influence the outcome of human studies. It is our hypothesis that genetic heterogeneity is an important determinant of vitamin E homeostasis. Therefore we have performed an in silico search for single nucleotide polymorp...

journal_title：IUBMB life

authors： Döring F,Rimbach G,Lodge JK

更新日期：2004-10-01 00:00:00

abstract：:Human ecto-ATPase (ecto-nucleoside triphosphate diphosphohydrolase 2 [eNTPDase2], also known as CD39L1) has been expressed and characterized in COS cells. It exhibits some unusual enzymology that is similar to a few members of this class of proteins but different from the majority of the family members. Hydrolysis of ...

journal_title：IUBMB life

authors： Hicks-Berger CA,Kirley TL

更新日期：2000-07-01 00:00:00

abstract：:Lysosomal storage disorders (LSDs) are inherited metabolic diseases caused by deficiencies in lysosomal proteins, which result in accumulation of undegraded metabolites and disruption of lysosomal proteostasis. Despite significant progress in the molecular genetics and biochemistry underlying the cellular pathogenesis...

journal_title：IUBMB life

authors： Segatori L

更新日期：2014-07-01 00:00:00

abstract：:Anthracyclines are a class of antitumor drugs widely used for the treatment of a variety of malignancy, including leukemias, lymphomas, sarcomas, and carcinomas. Different mechanisms have been proposed for anthracycline antitumor effects including free-radical generation, DNA intercalation/binding, activation of signa...

journal_title：IUBMB life

authors： Mordente A,Meucci E,Martorana GE,Giardina B,Minotti G

更新日期：2001-07-01 00:00:00

abstract：:S-Nitrosation is rapidly emerging as a regulatory mechanism in vascular biology, with particular importance in the onset of hyperpermeability induced by pro-inflammatory agents. This review focuses on the role of endothelial nitric oxide synthase (eNOS)-derived nitric oxide (NO) in regulating S-Nitrosation of adherens...

journal_title：IUBMB life

authors： Durán WN,Beuve AV,Sánchez FA

更新日期：2013-10-01 00:00:00

abstract：:Hepatitis C virus (HCV) is an enveloped positive-strand RNA virus of the Flaviviridae family. It has a genome of about 9,600 nucleotides encoding a large polyprotein (about 3,000 amino acids) that is processed by cellular and viral proteases into at least 10 structural and nonstructural viral proteins. A novel HCV pro...

journal_title：IUBMB life

authors： Vassilaki N,Mavromara P

更新日期：2009-07-01 00:00:00

abstract：:For 8 years, it was not understood why certain genes of plant mitochondria contain CGG (arginine) codons at positions where tryptophan codons (UGG) are present in the corresponding genes of nonplant species. Identification and sequencing of a tRNA(Trp) gene showed that it is not able to decode the CGG codon. Analysis ...

journal_title：IUBMB life

authors： Grienenberger JM

更新日期：2009-12-01 00:00:00

abstract：:Malaria remains a worldwide health concern with an estimated quarter of a billion people infected and nearly half a million deaths annually. Malaria is caused by a parasite infection from Plasmodium strains which are transmitted from mosquitoes into the human host. Although several small molecule inhibitors have been ...

journal_title：IUBMB life

authors： Helton LG,Kennedy EJ

更新日期：2020-06-01 00:00:00

abstract：:The reaction between nitric oxide ((.)NO) and oxygen yields reactive species capable of oxidizing and nitrosating proteins, as well as deaminating DNA bases. Although this reaction is considered too slow to be biologically relevant, it has been shown that membranes, lipoproteins, mitochondria and possibly proteins can...

journal_title：IUBMB life

authors： Möller MN,Li Q,Lancaster JR Jr,Denicola A

更新日期：2007-04-01 00:00:00

abstract：:We investigated signaling pathways leading to tumor necrosis factor (TNF) alpha-induced intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 expression in chondrosarcoma cells, and determined the functional significance of their expression by examining Jurkat T cell adhesion. TNFalpha ...

journal_title：IUBMB life

authors： Ju JW,Kim SJ,Jun CD,Chun JS

更新日期：2002-11-01 00:00:00

abstract：:Recently the crystal structure of creatine kinase from Torpedocalifornica was determined to 2.1 A. The dimeric structure revealed two different forms in the unit cell: one monomer was bound to a substrate, MgADP, and the other monomer was bound to a transition-state analogue complex composed of MgADP, nitrate and crea...

journal_title：IUBMB life

authors： Wang PF,Flynn AJ,McLeish MJ,Kenyon GL

更新日期：2005-04-01 00:00:00

abstract：:Prostate cancer (PCa) is considered the most common malignancy in men. The aim of this study is to assess the role of serum miR-15a and miR-16-1 expression in PCa development, diagnosis and prognosis aiming to find a specific noninvasive biomarker. This study comprised 70 patients with PCa, 70 patients complaining of ...

journal_title：IUBMB life

authors： Zidan HE,Abdul-Maksoud RS,Elsayed WSH,Desoky EAM

更新日期：2018-05-01 00:00:00

abstract：:Cartilage engineering is one challenging issue in regenerative medicine. Low oxygen tension or hypoxia inducible factor-1 (HIF-1α) gene therapy are promising strategies in the field of cartilage repair. Previously, we showed that hypoxia and its mediator HIF-1 regulate matrix genes expression (collagens and aggrecan)....

journal_title：IUBMB life

authors： Duval E,Bouyoucef M,Leclercq S,Baugé C,Boumédiene K

更新日期：2016-09-01 00:00:00

abstract：:Small extracellular vesicle (sEV) has precise impacts on tumor microenvironment and play vital functions in intercellular interaction. However, the functional role of sEV miRNA on laryngeal squamous cell carcinoma (LSCC) is largely unresolved. Here, the expression of miR-1246 in LSCC tissues and plasma sEV was examine...

journal_title：IUBMB life

authors： Huang Q,Hsueh CY,Guo Y,Wu XF,Li JY,Zhou L

更新日期：2020-07-01 00:00:00

abstract：:Role of nitric oxide (NO) on the expression of organic anion transporter 2 (OAT2) located in sinusoidal domain of hepatocytes has been investigated. Effect of NO generated in vivo in rat and delivered in vitro to hepatocytes was determined. Lipopolysaccharide (LPS) and spermine NONOate (SPER/NO) were selected as the N...

journal_title：IUBMB life

authors： Cha SH,Kim HP,Jung NH,Lee WK,Kim JY,Cha YN

更新日期：2002-09-01 00:00:00

abstract：:In tsRSV-infected NRK (tsNRK) cells, pp60(v-src) reactivation by temperature-shift from a nonpermissive temperature, 39 C, to a permissive one, 32 degrees C, induced the production of inositol phosphates (IPt) and phosphatidylethanol (PEt). This was accompanied by an increase in membrane-associated protein kinase C (P...

journal_title：IUBMB life

authors： Kim BY,Kim JH,Han YJ,Ahn SC,Kang DO,Oh WK,Ko HR,Lee HS,Mheen TI,Ahn JS

更新日期：1999-07-01 00:00:00

abstract：:Increasing evidence suggests a role for intracellular reactive oxygen species (ROS) as mediators of normal and pathological signal transduction pathways. In particular, a growing list of recent reports have demonstrated a rapid and significant increases in intracellular ROS following growth factor or cytokine stimulat...

journal_title：IUBMB life

authors： Finkel T

更新日期：2001-07-01 00:00:00

abstract：:Copper has a wide and important role in biological systems, determining conformation and activity of many metalloproteins and enzymes, such as cytochrome oxidase and superoxide dismutase . Furthermore, due to its possible reactivity with nonspecific proteins and toxic effects, elaborate systems of absorption, concentr...

journal_title：IUBMB life

authors： Inesi G

更新日期：2017-04-01 00:00:00

abstract：:Reactive oxygen and nitrogen species (ROS and RNS) have been extensively recognized as important signaling molecules implicated in physiological processes such as gene expression, cell differentiation and immune activation. Nevertheless, continuous production of these species may produce oxidative and/or nitrosative s...

journal_title：IUBMB life

authors： Rotilio G,Aquilano K,Ciriolo MR

更新日期：2003-10-01 00:00:00

abstract：:Synucleinopathies are neurodegenerative diseases characterized by the accumulation of either neuronal/axonal or glial insoluble proteinaceous aggregates mainly composed of α-synuclein (α-syn). Among them, the most common disorders are Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and some fo...

journal_title：IUBMB life

authors： Longhena F,Faustini G,Brembati V,Pizzi M,Bellucci A

更新日期：2020-04-01 00:00:00

abstract：:Modern cell-free in vitro protein synthesis systems present powerful tools for the synthesis of isotope-labeled proteins in high yields. The production of selectively 15 N-labeled proteins from 15 N-labeled amino acids is particularly economic and yields are often sufficient to analyze the proteins very quickly by two...

journal_title：IUBMB life

authors： Ozawa K,Dixon NE,Otting G

更新日期：2005-09-01 00:00:00

abstract：:The disappointing results from large clinical studies of α-tocopherol (αT), the major form of vitamin E in tissues, for prevention of chronic diseases including cancer have cast doubt on not only αT but also other forms of vitamin E regarding their role in preventing carcinogenesis. However, basic research has shown t...

journal_title：IUBMB life

authors： Jiang Q

更新日期：2019-04-01 00:00:00

abstract：:This review describes recent progress in the field of fibroblast growth factor receptors (FGFRs) with an emphasis on the role of FGFR mutants in skeletal malformations. This family of four receptors contains the most frequent germline mutations in humans. More than 75 mutations have been recorded, which account for mo...

journal_title：IUBMB life

authors： Kannan K,Givol D

更新日期：2000-03-01 00:00:00

abstract：:Antibiotic resistance in Acinetobacter spp., particularly Acinetobacter baumannii, is increasing rapidly. A. baumannii possesses two intrinsic β-lactamase genes, in addition to weak permeability and efflux systems, that together confer a natural reduced susceptibility to antibiotics. In addition, numerous acquired mec...

journal_title：IUBMB life

authors： Poirel L,Bonnin RA,Nordmann P

更新日期：2011-12-01 00:00:00

abstract：:Small noncoding RNAs are key controllers of cellular function, and their deregulation can lead to cancer development and metastatic evolution. This review summarizes the most important examples of small RNAs involved in human cancer and discusses their clinical use as biomarkers and drug targets for diagnosis, prognos...

journal_title：IUBMB life

authors： Rovira C,Güida MC,Cayota A

更新日期：2010-12-01 00:00:00

abstract：:Cellular nucleic acid binding protein (CNBP) has been implicated in vertebrate craniofacial development and in myotonic dystrophy type 2 (DM2) and sporadic inclusion body myositis (sIBM) human diseases. In these seemingly unrelated biological processes, CNBP appears to be involved in controlling cell death and prolife...

journal_title：IUBMB life

authors： Calcaterra NB,Armas P,Weiner AM,Borgognone M

更新日期：2010-10-01 00:00:00

abstract：:Matrix metalloproteinase-9 (MMP-9) regulates remodeling of the left ventricle after myocardial infarction (MI) and is tightly linked to the inflammatory response. The inflammatory response serves to recruit leukocytes as part of the wound healing reaction to the MI injury, and infiltrated leukocytes produce cytokines ...

journal_title：IUBMB life

authors： Deleon-Pennell KY,Altara R,Yabluchanskiy A,Modesti A,Lindsey ML

更新日期：2015-08-01 00:00:00

abstract：:The invasion and chemoresistance are crucial causes of morbidity and relapse for cancer patients. Axl is implicated in the modulation of cell invasion, cancer metastasis, and chemosensitivity in human breast carcinoma cell lines. Both breast cancer cell lines and tissues displayed increased expression of Axl, and it o...

journal_title：IUBMB life

authors： Li Y,Jia L,Ren D,Liu C,Gong Y,Wang N,Zhang X,Zhao Y

更新日期：2014-07-01 00:00:00