The efficacy and adverse effects of budesonide in remission induction treatment of autoimmune hepatitis: a retrospective study.

Abstract:

AIM:To compare the early biochemical response and rate of adverse effects in patients who received prednisolone (PRED)/azathioprine (AZA) and those who received budesonide (BUD)/AZA as the first-line treatment for autoimmune hepatitis. METHODS:The study involved 25 patients receiving PRED 30 mg/day + AZA 50 mg/day and 25 patients receiving BUD 9 mg/day + AZA 50 mg/day from February 2015 to February 2018. Biochemical and hemogram data at baseline and after 6 months of treatment, and adverse effects observed in the follow-up, were compared. RESULTS:There was no difference between the groups in biochemical response (17 patients receiving PRED/AZA and 18 receiving BUD/AZA) and the rate of adverse effects (9 patients receiving PRED/AZA and 5 receiving BUD/AZA). The total number of adverse effects in the BUD/AZA group was lower (15 vs 7) and the treatment was discontinued in 2 (8%) patients in PRED/AZA group, while no treatment discontinuation was observed in BUD/AZA group. CONCLUSIONS:This study showed no differences in biochemical response between the groups. Lower, although not significantly, rate of adverse effects and lower total number of adverse effects indicate that BUD/AZA may potentially be used as the first-line treatment of choice, especially in patients with obesity, diabetes, resistant hypertension, glaucoma, or osteoporosis.

journal_name

Croat Med J

journal_title

Croatian medical journal

authors

Binicier OB,Günay S

subject

Has Abstract

pub_date

2019-08-31 00:00:00

pages

345-351

issue

4

eissn

0353-9504

issn

1332-8166

journal_volume

60

pub_type

杂志文章
  • Authors, editors, policy makers, and the impact factor.

    abstract::Some aspects of the "impact factor", a quantitative measure of journals' influence on journals in scientific fields, were discussed in the preceding issue of the Croatian Medical Journal by Dr Eugene Garfield, one of its devisers. This factor can be of interest to authors, journal editors, and policy makers, but they ...

    journal_title:Croatian medical journal

    pub_type: 社论

    doi:

    authors: Huth EJ

    更新日期:2001-02-01 00:00:00

  • "Uncaging" using optical fibers to deliver UV light directly to the sample.

    abstract::Photolysis or "uncaging" of caged compounds represents a significant tool in cell biology and chemistry. It provides a means for quantitative control of compound delivery with temporal and spatial resolution while observing their consequences for cellular signaling. We discuss the use of ultraviolet-transmitting optic...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Parpura V,Haydon PG

    更新日期:1999-09-01 00:00:00

  • How to face the aging world - lessons from dementia research.

    abstract::A continuous rise in life expectancy has led to an increase in the number of senior citizens, now amounting to a fifth of the global population, and to a dramatic increase in the prevalence of diseases of the elderly. This review discusses the threat of dementia, a disease that imposes enormous financial burden on hea...

    journal_title:Croatian medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Mitrečić D,Petrović DJ,Stančin P,Isaković J,Zavan B,Tricarico G,Kujundžić Tiljak M,Di Luca M

    更新日期:2020-04-30 00:00:00

  • Influence of 1991-1995 war on breast-feeding in Croatia: questionnaire study.

    abstract:AIM:To investigate the influence of 1991-1995 war on the prevalence, duration, and practice of breast-feeding Croatian children up to 5 years of age. METHOD:In 1996, interviews were conducted in households with children up to 2 years of age (757 children) and 2-5 years of age (1,180 children). Data for war-free areas,...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Zakanj Z,Armano G,Grgurić J,Herceg-Cavrak V

    更新日期:2000-06-01 00:00:00

  • The role of the University of Zagreb School of Medicine in the development of education, health care, and science in Croatia.

    abstract:: ...

    journal_title:Croatian medical journal

    pub_type: 社论,历史文章

    doi:

    authors: Klarica M

    更新日期:2018-10-31 00:00:00

  • Bio-objects' political capacity: a research agenda.

    abstract::This article explores the merits of foregrounding the dichotomy of politicization vs de-politicization for our understanding of bio-objects in order to study their production, circulation, and governance in European societies. By asking how bio-objects are configured in science, policy, public, and media discourses an...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:10.3325/cmj.2013.54.206

    authors: Maeseele P,Hendrickx K,Pavone V,Van Hoyweghen I

    更新日期:2013-04-01 00:00:00

  • Identification and characterization of interleukin-13 receptor in human medulloblastoma and targeting these receptors with interleukin-13-pseudomonas exotoxin fusion protein.

    abstract:AIM:To identify and characterize the subunit structure of interleukin-13 receptor (IL-13R) in human medulloblastoma cell lines and target them with a chimeric fusion protein consisting of interleukin-13 and Pseudomonas exotoxin (termed as IL-13 cytotoxin). METHODS:Five human medulloblastoma cell lines were examined fo...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Joshi BH,Leland P,Puri RK

    更新日期:2003-08-01 00:00:00

  • Breastfeeding practices in Mostar, Bosnia and Herzegovina: cross-sectional self-report study.

    abstract:AIM:To investigate breastfeeding practices among mothers of infants in the city of Mostar, Bosnia and Herzegovina. METHODS:The cross-sectional self-report study was conducted among 326 mothers of infants visiting the Advisory Center for Infants at the Medical Center in Mostar and at the Children's Department of Mostar...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Simić T,Sumanović-Glamuzina D,Boranić M,Vuksić I,Boban A

    更新日期:2004-02-01 00:00:00

  • Carotid atherosclerosis and right ventricular diastolic dysfunction in a sample of hypertensive Nigerian patients.

    abstract:AIM:To determine the association of carotid atherosclerosis and right ventricular diastolic dysfunction (DD) among treated hypertensive Nigerian patients. METHODS:This was a single center cross-sectional study performed at the Cardiology Clinic of LAUTECH Teaching Hospital, Ogbomoso, Nigeria between January and Decemb...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:10.3325/cmj.2013.54.555

    authors: Akintunde AA,Adebayo PB,Aremu AA,Opadijo OG

    更新日期:2013-12-01 00:00:00

  • Therapies for multiple sclerosis targeting B cells.

    abstract::Increasing evidence suggests that B cells contribute both to the regulation of normal autoimmunity and to the pathogenesis of immune mediated diseases, including multiple sclerosis (MS). B cells in MS are skewed toward a pro-inflammatory profile, and contribute to MS pathogenesis by antibody production, antigen presen...

    journal_title:Croatian medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Milo R

    更新日期:2019-04-30 00:00:00

  • Optimization of a simple, automatable extraction method to recover sufficient DNA from low copy number DNA samples for generation of short tandem repeat profiles.

    abstract:AIM:To develop an automated, high throughput extraction protocol in order to produce database eligible profiles from fingerprints and other low copy number (LCN) DNA sources. METHODS:Extraction of either purified control DNA or buccal cells, for example, with commercial kits was compared to extraction with a simple di...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Schiffner LA,Bajda EJ,Prinz M,Sebestyen J,Shaler R,Caragine TA

    更新日期:2005-08-01 00:00:00

  • Countertransference problems in the treatment of a mixed group of war veterans and female partners of war veterans.

    abstract:AIM:Analysis of countertransference problems in the treatment of a heterogeneous group of war veterans. METHOD:The method used in this work was psychodynamic clinical observation and analysis of countertransference phenomena in group therapy. RESULTS:In the beginning of our work, we faced with a regressive group, whi...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Gregurek R

    更新日期:1999-12-01 00:00:00

  • Prediction of eye color in the Slovenian population using the IrisPlex SNPs.

    abstract:AIM:To evaluate the accuracy of eye color prediction based on six IrisPlex single nucleotide polymorphisms (SNP) in a Slovenian population sample. METHODS:Six IrisPlex predictor SNPs (HERC2 - rs12913832, OCA2 - rs1800407, SLC45A2 - rs16891982 and TYR - rs1393350, SLC24A4 - rs12896399, and IRF4 - rs12203592) of 105 ind...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:10.3325/cmj.2013.54.381

    authors: Kastelic V,Pośpiech E,Draus-Barini J,Branicki W,Drobnič K

    更新日期:2013-08-01 00:00:00

  • Opinions of Zagreb University students on professor-student dating.

    abstract:AIM:To investigate what Zagreb University students think about professor-student dating. METHODS:We surveyed 500 students from ten different Zagreb University schools using anonymous questionnaires. Twenty-five female and 25 male students from each school were asked to assess professor-student dating as either accepta...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Pulanić D,Skunca M,Jureković R,Obadić A,Ostojić-Pulanić B,Petrovecki M

    更新日期:2001-02-01 00:00:00

  • Comparison of protective effects of catechin applied in vitro and in vivo on ischemia-reperfusion injury in the isolated rat hearts.

    abstract:AIM:To determine overall cardiac effects of flavonoid catechin on ischemia-reperfusion injury in isolated rat hearts in vitro and in vivo. METHODS:After perfusing hearts at the pressure of 70 mm Hg, coronary perfusion was interrupted for 30 minutes and then re-established. There were four experimental groups, with 10 ...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Modun D,Music I,Katalinic V,Salamunic I,Boban M

    更新日期:2003-12-01 00:00:00

  • Growth pattern of Qatari preschool children.

    abstract:AIM:To compare the growth patterns of Qatari preschool children aged 0-5 years with the growth reference charts developed by the American National Center for Health Statistics and Centers for Disease Control and Prevention (NCHS/CDC). METHODS:The demographic data of weight, height, and age were collected in a cross-se...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Kamal AA,Bener A,Kareem Al-Mulla AM

    更新日期:2004-08-01 00:00:00

  • Validation of a short tandem repeat multiplex typing system for genetic individualization of domestic cat samples.

    abstract:AIM:To conduct developmental validation studies on a polymerase chain reaction (PCR) based short tandem repeat (STR) multiplex typing system, developed for the purpose of genetic individualization and parentage testing in domestic cat samples. METHODS:To evaluate reproducibility of the typing system, the multiplex was...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Coomber N,David VA,O'Brien SJ,Menotti-Raymond M

    更新日期:2007-08-01 00:00:00

  • Croatian genetic heritage: Y-chromosome story.

    abstract::The aim of this article is to offer a concise interpretation of the scientific data about the topic of Croatian genetic heritage that was obtained over the past 10 years. We made a short overview of previously published articles by our and other groups, based mostly on Y-chromosome results. The data demonstrate that C...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:10.3325/cmj.2011.52.225

    authors: Primorac D,Marjanović D,Rudan P,Villems R,Underhill PA

    更新日期:2011-06-01 00:00:00

  • Scientific production of research fellows at the Zagreb University School of Medicine, Croatia.

    abstract:AIM:To evaluate scientific production among research fellows employed at the Zagreb University School of Medicine and identify factors associated with their scientific output. METHOD:We conducted a survey among research fellows and their mentors during June 2005. The main outcome measure was publication success, defin...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Polasek O,Kolcić I,Buneta Z,Cikes N,Pećina M

    更新日期:2006-10-01 00:00:00

  • Prevalence of multiple sclerosis in Croatia: data from national and non-governmental organization registries.

    abstract:AIM:To update the estimate of multiple sclerosis (MS) prevalence in Croatia using multiple epidemiological tools. METHODS:This level IV, epidemiological study gathered data from three national patient registries and one database of a non-governmental MS patients' organization. Data were extracted on all individuals wh...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:10.3325/cmj.2018.59.65

    authors: Benjak T,Štefančić V,Draušnik Ž,Cerovečki I,Roginić D,Habek M,Mihel S,Stevanović R

    更新日期:2018-04-30 00:00:00

  • Tissue-protective activity of selenomethionine and D-panthetine in B16 melanoma-bearing mice under doxorubicin treatment is not connected with their ROS scavenging potential.

    abstract:AIM:To evaluate molecular mechanisms of tissue-protective effects of antioxidants selenomethionine (SeMet) and D-pantethine (D-Pt) applied in combination with doxorubicin (Dx) in B16 melanoma-bearing-mice. METHODS:Impact of the chemotherapy scheme on a survival of tumor-bearing animals, general nephro- and hepatotoxic...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:10.3325/cmj.2017.58.171

    authors: Panchuk RR,Skorokhyd NR,Kozak YS,Lehka LV,Moiseenok AG,Stoika RS

    更新日期:2017-04-14 00:00:00

  • Chromosomal microarray in clinical diagnosis: a study of 337 patients with congenital anomalies and developmental delays or intellectual disability.

    abstract:AIM:To determine the diagnostic yield and criteria that could help to classify and interpret the copy number variations (CNVs) detected by chromosomal microarray (CMA) technique in patients with congenital and developmental abnormalities including dysmorphia, developmental delay (DD) or intellectual disability (ID), au...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:10.3325/cmj.2017.58.231

    authors: Sansović I,Ivankov AM,Bobinec A,Kero M,Barišić I

    更新日期:2017-06-14 00:00:00

  • Medical education in Albania: current situation and perspective, with reference to primary care.

    abstract::A radical primary health care-oriented reform of the medical services in Albania is now under way, calling for adequate revision in medical education. The reform has started in 1994. In January 1997, the Department of Family Medicine at the Faculty of Medicine, University of Tirana, was established for the development...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Rrumbullaku L,Theodorakis PN,Caca P,Lionis C,Trell E

    更新日期:2002-02-01 00:00:00

  • Influence of a vertical subject on research in biomedicine and activities of The Cochrane Collaboration branch on medical students' knowledge and attitudes toward evidence-based medicine.

    abstract:AIM:To investigate whether the introduction of a vertical subject on research in biomedicine and founding of The Cochrane Collaboration branch at the University of Split School of Medicine influenced students' knowledge and attitudes toward evidence-based medicine (EBM), including the use of research literature. METHO...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:10.3325/cmj.2012.53.367

    authors: Balajić K,Barac-Latas V,Drenjancević I,Ostojić M,Fabijanić D,Puljak L

    更新日期:2012-08-01 00:00:00

  • Pregnant women quit smoking; what about fathers? Survey study in Bursa Region, Turkey.

    abstract:AIM:To evaluate maternal and paternal smoking habits during pregnancy and determine their correlation with pregnancy complications and newborn status. METHODS:The study included 499 pregnant women who delivered at the Department of Obstetrics and Gynecology in Uludag University School of Medicine, over a period of one...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Uncu Y,Ozcakir A,Ercan I,Bilgel N,Uncu G

    更新日期:2005-10-01 00:00:00

  • Assessment of psychological and social factors in adolescents risk behavior: questionnaire study.

    abstract:AIM:To investigate the influence of psychological and social factors on health risk behaviors, such as smoking, alcohol and psychoactive drug consumption among adolescents and to determine the prevalence of consuming various psychoactive substances. METHODS:The survey was conducted among adolescents in the Primorsko-g...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Malatestinić D,Mićović V,Kendel G,Baricev-Novaković Z

    更新日期:2005-02-01 00:00:00

  • Immunoprophylactic intravesical application of bacillus Calmette-Guerin after transurethral resection of superficial bladder cancer.

    abstract:AIM:To evaluate the effect of intravesical instillation of Bacillus Calmette-Guerin (BCG) in the prevention of recurrence and progression of the superficial bladder cancer. METHODS:Between February 1989 and May 1994, 170 patients with histologically proven superficial transitional cell carcinoma of the bladder stage T...

    journal_title:Croatian medical journal

    pub_type: 临床试验,杂志文章

    doi:

    authors: Librenjak D,Situm M,Eterovic D,Dogas Z,Gotovac J

    更新日期:2003-04-01 00:00:00

  • Sonographic measurements of subcutaneous fetal fat in pregnancies complicated by gestational diabetes and in normal pregnancies.

    abstract:AIM:To compare sonographic measurements of fetal fat tissue in pregnancies complicated by gestational diabetes (GD), with patients undergoing either a diet only or a combined diet and insulin treatment, to those obtained in pregnancies with a normal glucose challenge test. METHODS:Forty-five singleton pregnancies comp...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Rigano S,Ferrazzi E,Radaelli T,Cetin ET,Pardi G

    更新日期:2000-09-01 00:00:00

  • What is happening to the health of the Croatian population?

    abstract:AIM:To describe the problems in the interpretation of Croatian mortality data and explore possible reasons for the recorded increase in mortality in the 1990-1999 period, particularly related to different methods of collection and estimation of data on deaths and population. METHODS:Numbers of recorded deaths and popu...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:

    authors: Bozicević I,Oresković S,Stevanović R,Rodin U,Nolte E,McKee M

    更新日期:2001-12-01 00:00:00

  • Physical activity of Croatian population: cross-sectional study using International Physical Activity Questionnaire.

    abstract:AIM:To determine the physical activity level of the Croatian population in different domains of everyday life. METHODS:A random stratified sample of 1032 Croatians aged 15 years and older was interviewed using the official Croatian long version of the International Physical Activity Questionnaire (IPAQ). Total physica...

    journal_title:Croatian medical journal

    pub_type: 杂志文章

    doi:10.3325/cmj.2009.50.165

    authors: Jurakić D,Pedisić Z,Andrijasević M

    更新日期:2009-04-01 00:00:00