Abstract：
:A continuous rise in life expectancy has led to an increase in the number of senior citizens, now amounting to a fifth of the global population, and to a dramatic increase in the prevalence of diseases of the elderly. This review discusses the threat of dementia, a disease that imposes enormous financial burden on health systems and warrants efficient therapeutic solutions. What we learned from numerous failed clinical trials is that we have to immediately take into account two major elements: early detection of dementia, much before the onset of symptoms, and personalized (precision) medicine treatment approach. We also discuss some of the most promising therapeutic directions, including stem cells, exosomes, electromagnetic fields, and ozone.
journal_name
Croat Med Jjournal_title
Croatian medical journalauthors
Mitrečić D,Petrović DJ,Stančin P,Isaković J,Zavan B,Tricarico G,Kujundžić Tiljak M,Di Luca Msubject
Has Abstractpub_date
2020-04-30 00:00:00pages
139-146issue
2eissn
0353-9504issn
1332-8166journal_volume
61pub_type
杂志文章,评审abstract：AIM:To evaluate risk factors related to total mortality in an unselected population of patients implanted with a cardioverter defibrillator. METHODS:Survival analysis was performed retrospectively investigating the records of 77 consecutive patients implanted with defibrillators (median 67 years, range 38-83 years; 63...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2007-02-01 00:00:00
abstract：:A study was conducted to determine if modern forensic DNA typing methods can be properly employed throughout the world with a final goal of increasing arrests, prosecutions, and convictions of perpetrators of modern day trafficking in persons while concurrently reducing the burden of victim testimony in legal proceedi...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：10.3325/cmj.2014.55.3
更新日期：2014-02-01 00:00:00
abstract：AIM:To determine types and frequency of CAPN3 mutations in 29 unrelated Croatian families, analyzed during 6-year prospective and ongoing genetic and epidemiological study of muscular dystrophies in Croatia. METHODS:Mutation analysis included allele-specific polymerase chain reaction (PCR) or combination of PCR and re...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2005-08-01 00:00:00
abstract：AIM:To determine the prevalence and intercorrelation of different forms of childhood maltreatment and psychological problems in adolescents in Western Herzegovina Canton. METHOD:A questionnaire study was conducted in March 2003 on a convenient sample of 458 third-grade high-school students (39% boys) aged between 15 a...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：10.3325/cmj.2008.2.243
更新日期：2008-04-01 00:00:00
abstract：:Susac syndrome is a rare microangiopathy of cochlea, retina, and brain. We report a case of a 30-year-old man with Susac syndrome. The patient initially suffered from unilateral hearing loss associated with peripheral vestibular syndrome, and followed with recurrent arterial retinal occlusions and encephalopathy. The ...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
abstract：:Hereditary factor XI (FXI) deficiency is a mild bleeding disorder, rare in the general population but relatively common among Ashkenazi Jews. The human F11 gene comprises 15 exons, spanning over 23 kb of the long arm of chromosome 4 (4q35). Homozygotes or compound heterozygotes typically show severe FXI deficiency, wh...
journal_title：Croatian medical journal
pub_type：
doi：
更新日期：2020-02-29 00:00:00
abstract：AIM:To immunohistochemically evaluate the expression of MAGE-A1, MAGE-A, and NY-ESO-1 cancer/testis (C/T) tumor antigens in medullary breast cancer (MBC) tumor samples and to analyze it in relation to the clinicopathological features. METHODS:This retrospective study included samples from 49 patients: 40 with typical ...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：10.3325/cmj.2011.52.171
更新日期：2011-04-15 00:00:00
abstract：:Academic medicine integrates three of the most honorable human activities: treating the ill, teaching, and research. The quality that all three share is persistent quest for truth. However, there is reluctance of academic medicine today to openly defend scientific truth by challenging the arguments and the very existe...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2004-12-01 00:00:00
abstract：:We analyzed forensic DNA samples from four cases of sexual assault, using the Y-chromosome-specific human DNA markers and a panel of autosomal short tandem repeats (STRs). The presence of male contribution was evaluated by the analysis of the Amelogenin locus. A panel of tetrameric Y-STR (DYS19, DYS390, DYS391, DYS392...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2003-06-01 00:00:00
abstract：AIM:To evaluate long-term cognitive consequences of subarachnoid hemorrhage with good outcome and the opinion of patients and their relatives about these consequences. METHODS:The study included 10 patients surgically treated for subarachnoid hemorrhage due to the rupture of aneurysm of the anterior communicating arte...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2006-04-01 00:00:00
abstract：:Increasing evidence suggests that B cells contribute both to the regulation of normal autoimmunity and to the pathogenesis of immune mediated diseases, including multiple sclerosis (MS). B cells in MS are skewed toward a pro-inflammatory profile, and contribute to MS pathogenesis by antibody production, antigen presen...
journal_title：Croatian medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2019-04-30 00:00:00
abstract：AIM:To assess the usefulness of a DNA-based method for identifying mushroom species for application in forensic laboratory practice. METHODS:Two hundred twenty-one samples of clinical forensic material (dried mushrooms, food remains, stomach contents, feces, etc) were analyzed. ITS2 region of nuclear ribosomal DNA (nr...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：10.3325/cmj.2015.56.32
更新日期：2015-02-01 00:00:00
abstract：:To examine ways of ensuring access to health services within the framework of primary health care (PHC), since the goal of PHC to make universal health care available to all people has become increasingly neglected amid emerging themes of globalization, trade, and foreign policy. From a public health point of view, we...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：10.3325/2010.51.181
更新日期：2010-06-01 00:00:00
abstract：AIM:To investigate whether the introduction of a vertical subject on research in biomedicine and founding of The Cochrane Collaboration branch at the University of Split School of Medicine influenced students' knowledge and attitudes toward evidence-based medicine (EBM), including the use of research literature. METHO...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：10.3325/cmj.2012.53.367
更新日期：2012-08-01 00:00:00
abstract：AIM:To investigate the relationships between body mass index (BMI), dietary habits, and cardiovascular risk factors in isolated Adriatic island populations of Croatia. METHODS:Random sample of subjects (n=1001) was interviewed, using a validated questionnaire developed for this research program. Dietary habits were as...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2006-08-01 00:00:00
abstract：AIM:To establish the incidence of tumors of the central nervous system (CNS) in the population of Labin area in Istria, Croatia, characterized by very little population migration. METHOD:We retrospectively analyzed data on 175 patients (102 men and 73 women) diagnosed with CNS tumor according to the World Health Organ...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2004-04-01 00:00:00
abstract：AIM:To analyze the incidence, transvaginal detection age, sonographic appearance, clinical course, and outcomes of pregnancy in cases with abnormal fetal brain structure and/or circulation, and to evaluate the clinical significance of sonographic abnormalities. METHODS:Serial observation of the fetal brain and intracr...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：:Advances in mechanical circulatory support have significantly expanded the treatment options for patients with heart failure, whether acute or chronic. There are numerous devices available that offer patients short-, intermediate-, and long-term duration of support depending on their clinical needs and cardiac recover...
journal_title：Croatian medical journal
pub_type： 杂志文章,评审
doi：10.3325/cmj.2014.55.596
更新日期：2014-12-01 00:00:00
abstract：AIM:To examine relationships among combat exposure, posttraumatic stress disorder (PTSD) symptoms, depression, suicidality, nicotine dependence, and religiosity in Croatian veterans. METHODS:This cross-sectional study used Combat Exposure Scale (CES) to quantify the stressor severity, PTSD Checklist 5 (PCL) to quantif...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2018-08-31 00:00:00
abstract：AIM:To provide a screening tool to reduce time and sample consumption when attempting mitochondrial DNA (mtDNA) haplogroup typing. METHODS:A single base primer extension assay was developed to enable typing, in a single reaction, of twelve mtDNA haplogroup specific polymorphisms. For validation purposes a total of 147...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2007-08-01 00:00:00
abstract：AIM:To assess the ability to work and employability of individuals taking part in opioid substitution treatment programs (OSTP). METHODS:The study was composed of two surveys. In the first survey, 237 of 480 patients enrolled in OSTP responded to the questionnaire about their employment status, opinion about employmen...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：10.3325/cmj.2008.49.842
更新日期：2008-12-01 00:00:00
abstract：AIM:To present two patients with basaloid squamous cell carcinoma of the larynx, a rare, highly aggressive variant of the squamous cell carcinoma. METHODS:Surgical excision of the polypoid tumor of the anterior comissure of the larynx was performed in a 62 year-old male, and in the second case, total laryngectomy with...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：AIM:To evaluate the effect of intravesical instillation of Bacillus Calmette-Guerin (BCG) in the prevention of recurrence and progression of the superficial bladder cancer. METHODS:Between February 1989 and May 1994, 170 patients with histologically proven superficial transitional cell carcinoma of the bladder stage T...
journal_title：Croatian medical journal
pub_type： 临床试验,杂志文章
doi：
更新日期：2003-04-01 00:00:00
abstract：AIM:To determine the usefulness of dental methods in the identification of victims in the railway accident in Zagreb (August 30, 1974) and midair collision of a British and a Slovenian airplane near Vrbovec (September 10, 1976). METHODS:There were 152 people killed in the railway accident, and 176 fatalities in the pl...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：AIM:To assess the seroprevalence of human metapneumovirus (hMPV) in Croatia. METHODS:During 2005, a total of 137 serum specimens from Croatian patients aged from 6 days to 51 years, without respiratory symptoms, were collected at the Croatian National Institute of Public Health. The sera were examined using the indire...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2006-12-01 00:00:00
abstract：AIM:Several amplification and detection formats for the analysis of short tandem repeat loci are readily available to the forensic laboratory. Careful consideration must be given to the throughput, sensitivity, concordance, data interpretation, facility requirements, and costs of operation. The Pennsylvania State Polic...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2001-06-01 00:00:00
abstract：:Health and health care provision are among the most important and politically sensitive public service areas. Politicians carefully incorporate health care program changes in their political agendas to gain votes. However, knowing health care priorities of the electoral body is not useful only to politicians, but also...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2006-06-01 00:00:00
abstract：AIM:To determine sociodemographic features that describe mothers who are likely to wean their babies earlier then is recommended and whether the rates of breast-fed children in Croatia had improved since 1996. METHODS:A sample of 500 mothers was selected from the population of women who had delivered 2 to 12 months be...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2003-10-01 00:00:00
abstract：:Corporate medical practice, a market economy, and a consumer culture are transforming health care. The service relationships of doctors with patients are now commodities. The doctor, directed by disease management protocols (to improve outcomes, reduce costs, and standardize care), is, in effect, providing programmed ...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：:This article explores the merits of foregrounding the dichotomy of politicization vs de-politicization for our understanding of bio-objects in order to study their production, circulation, and governance in European societies. By asking how bio-objects are configured in science, policy, public, and media discourses an...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：10.3325/cmj.2013.54.206
更新日期：2013-04-01 00:00:00
