Abstract:
:Particulate matter (PM), a widespread air pollutant, consists of a complex mixture of solid and liquid particles suspended in air. Many diseases have been linked to PM exposure, which induces an imbalance in reactive oxygen species (ROS) generated in cells, and might result in skin diseases (such as aging and atopic dermatitis). New techniques involving nanomedicine and nano-delivery systems are being rapidly developed in the medicinal field. Fullerene, a kind of nanomaterial, acts as a super radical scavenger. Lower water solubility levels limit the bio-applications of fullerene. Hence, to improve the water solubility of fullerene, while retaining its radical scavenger functions, a fullerene derivative, fullerenol C60(OH)36, was synthesized, to examine its biofunctions in PM-exposed human keratinocyte (HaCaT) cells. The PM-induced increase in ROS levels and expression of phosphorylated mitogen-activated protein kinase and Akt could be inhibited via fullerenol pre-treatment. Furthermore, the expression of inflammation-related proteins, cyclooxygenase-2, heme oxygenase-1, and prostaglandin E2 was also suppressed. Fullerenol could preserve the impaired state of skin barrier proteins (filaggrin, involucrin, repetin, and loricrin), which was attributable to PM exposure. These results suggest that fullerenol could act against PM-induced cytotoxicity via ROS scavenging and anti-inflammatory mechanisms, and the maintenance of expression of barrier proteins, and is a potential candidate compound for the treatment of skin diseases.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Lee CW,Chi MC,Peng KT,Chiang YC,Hsu LF,Yan YL,Li HY,Chen MC,Lee IT,Lai CHdoi
10.3390/ijms20174259subject
Has Abstractpub_date
2019-08-30 00:00:00issue
17issn
1422-0067pii
ijms20174259journal_volume
20pub_type
杂志文章abstract::Molecular characterization of Circulating Tumor Cells (CTCs) is still challenging, despite attempts to minimize the drawbacks of Whole Genome Amplification (WGA). In this paper, we propose a Next-Generation Sequencing (NGS) optimized protocol based on molecular tagging technology, in order to detect CTCs mutations whi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21124364
更新日期:2020-06-19 00:00:00
abstract::Clinical applications of camptothecin (CPT) have been heavily hindered due to its non-targeted toxicity, active lactone ring instability, and poor water solubility. Targeted drug delivery systems may offer the possibility to overcome the above issues as reported. In this research, a series of prostate-specific membran...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19103251
更新日期:2018-10-19 00:00:00
abstract::Spider silk is self-assembled from water-soluble silk proteins through changes in the environment, including pH, salt concentrations, and shear force. The N-terminal domains of major and minor ampullate silk proteins have been found to play an important role in the assembly process through salt- and pH-dependent dimer...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21124466
更新日期:2020-06-23 00:00:00
abstract::The objectives of this investigation were to produce a novel chitosanase for application in industries and waste treatment. The transformation of chitinous biowaste into valuable bioactive chitooligomers (COS) is one of the most exciting applications of chitosanase. An amphiprotic novel chitosanase from Bacillus mycoi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17081302
更新日期:2016-08-10 00:00:00
abstract::Chronic infection with hepatitis C virus (HCV) is a major cause of hepatocellular carcinoma (HCC). Novel treatments with direct-acting antivirals achieve high rates of sustained virologic response; however, the HCC risk remains elevated in cured patients, especially those with advanced liver disease. Long-term HCV inf...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21093057
更新日期:2020-04-26 00:00:00
abstract::Gram-negative bacteria have an outer membrane inhibiting the entry of antibiotics. Porins, found within the outer membrane, are involved in regulating the permeability of β-lactam antibiotics. β-lactamases are enzymes that are able to inactivate the antibacterial properties of β-lactam antibiotics. Interestingly, pori...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21082822
更新日期:2020-04-17 00:00:00
abstract::Aflatoxin B(1) (AFB(1)) is commonly found in cereals and animal feeds and causes a significant threat to the food industry and animal production. Several microbial isolates with high AFB(1) transformation ability have been identified in our previous studies. The aim of this research was to characterize one of those is...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms11104063
更新日期:2010-10-20 00:00:00
abstract:BACKGROUND:P1G10 is a cysteine proteolytic fraction from Vasconcellea cundinamarcensis latex, obtained by chromatographic separation on Sephadex-G10 and ultrafiltration. This fraction enhances healing in different models of skin lesions, and displays a protective/healing effect against gastric ulcers, where it was sugg...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20184373
更新日期:2019-09-06 00:00:00
abstract::Kentucky bluegrass (KB, Poa pratensis) is one of the most widely used cool-season turfgrass species, but it is sensitive to drought stress. Molecular studies in KB are hindered by its large and complex genome structure. In this study, a comparative transcriptomic study was conducted between a short and long period of ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20061289
更新日期:2019-03-14 00:00:00
abstract::Understanding the composition and structure of the acquired enamel pellicle (AEP) has been a major goal in oral biology. Our lab has conducted studies on the composition of AEP formed on permanent enamel. The exhaustive exploration has provided a comprehensive identification of more than 100 proteins from AEP formed o...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms14010920
更新日期:2013-01-07 00:00:00
abstract::Wintersweet (Chimonanthus praecox) is a well-known traditional fragrant plant and a winter-flowering deciduous shrub that originated in China. The five different developmental stages of wintersweet, namely, flower-bud period (FB), displayed petal stage (DP), open flower stage (OF), later blooming period (LB), and wilt...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19103278
更新日期:2018-10-22 00:00:00
abstract::Four chiral Schiff base binuclear 3d-4f complexes (NdNi, NdCu, GdNi, and GdCu) have been prepared and characterized by means of electronic and CD spectra, IR spectra, magnetic measurements, and X-ray crystallography (NdNi). A so-called artifact peak of solid state CD spectra, which was characteristic of oriented molec...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms12106966
更新日期:2011-01-01 00:00:00
abstract::Mitochondria in neurons contribute to energy supply, the regulation of synaptic transmission, Ca2+ homeostasis, neuronal excitability, and stress adaptation. In recent years, several studies have highlighted that the neurotransmitter serotonin (5-HT) plays an important role in mitochondrial biogenesis in cortical neur...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21249629
更新日期:2020-12-17 00:00:00
abstract::In previous work, a 93-mer aptamer was selected against the anaphylactic allergen, β-conglutin and truncated to an 11-mer, improving the affinity by two orders of magnitude, whilst maintaining the specificity. This 11-mer was observed to fold in a G-quadruplex, and preliminary results indicated the existence of a comb...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22031150
更新日期:2021-01-24 00:00:00
abstract::Vortioxetine is a novel, multimodal antidepressant with unique targets, including the inhibition of the serotonin transporter (SET), of serotonin 5-HT3 (5-HT3R), and of 5-HT7 (5-HT7R) receptors and partial agonism to serotonin 5-HT1A (5-HT1AR) receptors in humans. Vortioxetine has a lower affinity to 5-HT1AR and 5-HT7...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20246235
更新日期:2019-12-10 00:00:00
abstract::Present day awareness of biofilm colonization on polymeric surfaces has prompted the scientific community to develop an ever-increasing number of new materials with anti-biofilm features. However, compared to the large amount of work put into discovering potent biofilm inhibitors, only a small number of papers deal wi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20153794
更新日期:2019-08-03 00:00:00
abstract::Going from bench to bedside is a simplified description of translational research, with the ultimate goal being to improve the health status of mankind. Tumor endothelial cells (TECs) perform angiogenesis to support the growth, establishment, and dissemination of tumors to distant organs. TECs have various features th...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21093238
更新日期:2020-05-03 00:00:00
abstract::Synovial inflammation plays an important role in the pathogenesis and progress of osteoarthritis (OA). There is an urgent need to find safe and effective drugs that can reduce the inflammation and regulate the pathogenesis of cytokines of the OA disease. Here, we investigated the effect of icariin, the major pharmacol...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18122656
更新日期:2017-12-08 00:00:00
abstract::Erythroid Differentiation Regulator 1 (Erdr1) is known as a hemoglobin synthesis factor which also regulates cell survival under conditions of stress. In addition, previous studies have revealed the effects of Erdr1 on cancer progression and its negative correlation with interleukin (IL)-18, a pro-inflammatory cytokin...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms17122059
更新日期:2016-12-08 00:00:00
abstract::Neuropeptides such as vasoactive intestinal peptide (VIP) and calcitonin gene-related peptide (CGRP) are present in nerve fibers of bone tissues and have been suggested to potentially regulate bone remodeling. Oscillatory fluid flow (OFF)-induced shear stress is a potent signal in mechanotransduction that is capable o...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms15045874
更新日期:2014-04-08 00:00:00
abstract::Methyl jasmonate (MeJA), synthesized in the jasmonic acid (JA) pathway, has been found to upregulate glucosinolate (GS) biosynthesis in plant species of the Brassicaceae family. Exogenous application of MeJA has shown to increase tissue GS concentrations and the formation of myrosinase-mediated GS hydrolysis products ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19041058
更新日期:2018-04-02 00:00:00
abstract::Remote ischemic conditioning (RIC) confers cardioprotection in patients with ST-segment elevation myocardial infarction (STEMI). Despite intense research, the translation of RIC into clinical practice remains a challenge. This may, at least partly, be due to confounding factors that may modify the efficacy of RIC. The...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20133246
更新日期:2019-07-02 00:00:00
abstract::Pterosins are abundant in ferns, and pterosin A was considered a novel activator of adenosine monophosphate-activated protein kinase, which is crucial for regulating blood glucose homeostasis. However, the distribution of pterosins in different species of ferns from various places in Taiwan is currently unclear. To ad...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms16022497
更新日期:2015-01-22 00:00:00
abstract::Simultaneous imaging of multiple targets (SIMT) in opaque biological tissues is an important goal for molecular imaging in the future. Multi-color fluorescence imaging in deep tissues is a promising technology to reach this goal. In this work, we developed a dual-modality imaging system by combining our recently devel...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18020323
更新日期:2017-02-04 00:00:00
abstract::Ascorbate oxidase (AO) plays important roles in plant growth and development. Previously, we reported a cotton AO gene that acts as a positive factor in cell growth. Investigations on Gossypium hirsutum AO (GhAO) family genes and their multiple functions are limited. The present study identified eight GhAO family gene...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20246167
更新日期:2019-12-06 00:00:00
abstract::SwissDrugDesign is an important initiative led by the Molecular Modeling Group of the SIB Swiss Institute of Bioinformatics. This project provides a collection of freely available online tools for computer-aided drug design. Some of these web-based methods, i.e., SwissSimilarity and SwissTargetPrediction, were especia...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20184612
更新日期:2019-09-18 00:00:00
abstract::Programmed cell death, such as apoptosis and autophagy, are key processes that are activated early on during development, leading to remodelling in embryos and homeostasis in adult organisms. Genomic conservation of death factors has been largely investigated in the animal and plant kingdoms. In this study, we analyse...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21155201
更新日期:2020-07-22 00:00:00
abstract::Krüppel-like factor 4 (Klf4) plays an important role in the transition from proliferation to differentiation in a wide variety of cells. Previous studies demonstrated its critical role in the luteal transition of preovulatory granulosa cells (GCs). This study used cultured rat preovulatory GCs to investigate the mecha...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21197385
更新日期:2020-10-06 00:00:00
abstract::Relaxin is known to play an important role in animal pregnancies, including those of humans. It is suggested that relaxin induces aggressive cell growth and invasiveness in several types of cancer, including endometrial cancer. However, the mechanisms of relaxin remain largely unclear. In this study, we examined the e...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19082438
更新日期:2018-08-18 00:00:00
abstract::Molecular chaperones are key components of the protein homeostasis system against protein misfolding and aggregation. It has been recently shown that these molecules can be rationally modified to have an enhanced activity against specific amyloidogenic substrates. The resulting molecular chaperone variants can be effe...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19051443
更新日期:2018-05-12 00:00:00