Abstract：
:Simultaneous imaging of multiple targets (SIMT) in opaque biological tissues is an important goal for molecular imaging in the future. Multi-color fluorescence imaging in deep tissues is a promising technology to reach this goal. In this work, we developed a dual-modality imaging system by combining our recently developed ultrasound-switchable fluorescence (USF) imaging technology with the conventional ultrasound (US) B-mode imaging. This dual-modality system can simultaneously image tissue acoustic structure information and multi-color fluorophores in centimeter-deep tissue with comparable spatial resolutions. To conduct USF imaging on the same plane (i.e., x-z plane) as US imaging, we adopted two 90°-crossed ultrasound transducers with an overlapped focal region, while the US transducer (the third one) was positioned at the center of these two USF transducers. Thus, the axial resolution of USF is close to the lateral resolution, which allows a point-by-point USF scanning on the same plane as the US imaging. Both multi-color USF and ultrasound imaging of a tissue phantom were demonstrated.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Kandukuri J,Yu S,Cheng B,Bandi V,D'Souza F,Nguyen KT,Hong Y,Yuan Bdoi
10.3390/ijms18020323subject
Has Abstractpub_date
2017-02-04 00:00:00issue
2issn
1422-0067pii
ijms18020323journal_volume
18pub_type
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