Abstract:
:Going from bench to bedside is a simplified description of translational research, with the ultimate goal being to improve the health status of mankind. Tumor endothelial cells (TECs) perform angiogenesis to support the growth, establishment, and dissemination of tumors to distant organs. TECs have various features that distinguish them from normal endothelial cells, which include alterations in gene expression patterns, higher angiogenic and metabolic activities, and drug resistance tendencies. The special characteristics of TECs enhance the vulnerability of tumor blood vessels toward antiangiogenic therapeutic strategies. Therefore, apart from being a viable therapeutic target, TECs would act as a better mediator between the bench (i.e., angiogenesis research) and the bedside (i.e., clinical application of drugs discovered through research). Exploitation of TEC characteristics could reveal unidentified strategies of enhancing and monitoring antiangiogenic therapy in the treatment of cancer, which are discussed in this review.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Annan DA,Kikuchi H,Maishi N,Hida Y,Hida Kdoi
10.3390/ijms21093238subject
Has Abstractpub_date
2020-05-03 00:00:00issue
9issn
1422-0067pii
ijms21093238journal_volume
21pub_type
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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