Abstract:
:I have read with interest the recent paper by Han and coworkers on the putative effects of a PHACTR1 variant in the context of coronary artery disease. The authors conclude to a significant risk-enhancing role of rs12526453 on the grounds of 19 earlier case-control studies.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Sand PGdoi
10.3390/ijms16059770subject
Has Abstractpub_date
2015-04-29 00:00:00pages
9770-1issue
5issn
1422-0067pii
ijms16059770journal_volume
16pub_type
评论,杂志文章abstract::Topical or systemic administration of JAK inhibitors has been shown to be a new treatment modality for severe alopecia areata (AA). Some patients show a good response to JAK inhibitors, but frequently relapse after cessation of the treatment. There have been no guidelines about the indications and use of JAK inhibitor...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21145137
更新日期:2020-07-20 00:00:00
abstract::Calmodulin (CaM) is an important intracellular protein that binds Ca2+ and functions as a critical second messenger involved in numerous biological activities through extensive interactions with proteins and peptides. CaM's ability to adapt to binding targets with different structures is related to the flexible centra...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms22010308
更新日期:2020-12-30 00:00:00
abstract::Inflammatory bowel disease (IBD) is a chronic disorder manifested as Crohn's disease (CD) and ulcerative colitis (UC) characterized by intestinal inflammation and involves a dysregulated immune response against commensal microbiota through the activation of CD4 T helper cells. T helper cell differentiation to effector...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21093379
更新日期:2020-05-11 00:00:00
abstract::Previous studies have shown that germin-like proteins (GLPs) are present ubiquitously in rice and Arabidopsis. However, the understanding regarding their role in development and abiotic/biotic stress resistance remains limited. In the present study, we report genome-wide identification, characterisation, subcellular l...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17101622
更新日期:2016-09-23 00:00:00
abstract::Molecular etiology of thyroid cancers has been widely studied, and several molecular alterations have been identified mainly associated with follicular and papillary histotypes. However, the molecular bases of the complex pathogenesis of thyroid carcinomas remain poorly understood. HOX genes regulate normal embryonic ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms141121727
更新日期:2013-11-01 00:00:00
abstract::The effective dose of irradiation to control pest mites in quarantine has been studied extensively, but the molecular mechanisms underlying the effects of the irradiation on mites are largely unknown. In this study, exposure to 400 Gy of γ rays had significant (p < 0.05) effects on the adult survival, fecundity and eg...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms161126004
更新日期:2015-11-11 00:00:00
abstract::Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolates are known to tolerate superior quinolone antimicrobials compared with other antibacterial agents. Among the clones belonging to sequence type (ST) 131 by multilocus sequence typing, the involvement of the H30-Rx subclone has been reported worldwi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20205162
更新日期:2019-10-18 00:00:00
abstract::Simultaneous imaging of multiple targets (SIMT) in opaque biological tissues is an important goal for molecular imaging in the future. Multi-color fluorescence imaging in deep tissues is a promising technology to reach this goal. In this work, we developed a dual-modality imaging system by combining our recently devel...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18020323
更新日期:2017-02-04 00:00:00
abstract::Fluorescent silica nanoparticles (FSNPs) can provide high-intensity and photostable fluorescent signals as a probe for biomedical analysis. In this study, FSNPs hybridized with aggregation-induced emission (AIE) luminogens (namely FSNP-SD) were successfully fabricated by a surfactant-free sol-gel method. The FSNP-SD w...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms14011080
更新日期:2013-01-07 00:00:00
abstract::Synthesis and anticonvulsant potential of certain new 6-aryl-9-substituted-6,9-diazaspiro[4.5]decane-8,10-diones (6a-l) and 1-aryl-4-substituted-1,4-diazaspiro[5.5] undecane-3,5-diones (6m-x) are reported. The intermediates 1-[(aryl)(cyanomethyl)amino] cycloalkanecarboxamides (3a-f) were prepared via adopting Strecker...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms150916911
更新日期:2014-09-23 00:00:00
abstract::Nut-based milks and yogurts are gaining popularity, but may not offer the same benefits as dairy yogurts to consumers. Cashew nuts often cause severe allergic reactions, and cashew nut allergens are stable to several types of processing. To compare its characteristics to dairy yogurt and characterize the effects of fe...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21218267
更新日期:2020-11-04 00:00:00
abstract::Evaluation of relationships between molecular modeling structural parameters and high-performance liquid chromatography (HPLC) retention data of 11 cardiovascular system drugs by principal component analysis (PCA) in relation to their pharmacological activity was performed. The six retention data parameters were deter...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms11072681
更新日期:2010-07-09 00:00:00
abstract::The development of neural circuits is a complex process that relies on the proper navigation of axons through their environment to their appropriate targets. While axon-environment and axon-target interactions have long been known as essential for circuit formation, communication between axons themselves has only more...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21145170
更新日期:2020-07-21 00:00:00
abstract::The study of the human microbiome has become a very popular topic. Our microbial counterpart, in fact, appears to play an important role in human physiology and health maintenance. Accordingly, microbiome alterations have been reported in an increasing number of human diseases. Despite the huge amount of data produced...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19020383
更新日期:2018-01-27 00:00:00
abstract::The consumption of carotenoid-rich vegetables such as tomatoes and tomato sauces is associated with reduced risk of several chronic diseases. The predominant carotenoids in tomato products are in the (all-E) configuration, but (Z) isomers can be formed during thermal processing. The effect of cooking time (15, 30, 45 ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms16059588
更新日期:2015-04-28 00:00:00
abstract::The objectives of this study were to evaluate the binding behavior of Cu(II) and Eu(III) with water extractable organic matter (WEOM) in soil, and assess the competitive effect of the cations. Excitation-emission matrix (EEM) fluorescence spectrometry was used in combination with parallel factor analysis (PARAFAC) to ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms160714464
更新日期:2015-06-25 00:00:00
abstract::Intestinal absorption and barrier malfunctions are associated with endoplasmic reticulum stress (ERS) in the intestine. We induced ERS by exposing the intestinal porcine epithelial cell line J2 (IPEC-J2) to tunicamycin (TUNI) to explore the potential of l-glutamine to reduce ERS-induced apoptosis. Our experiments demo...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18122617
更新日期:2017-12-05 00:00:00
abstract::Presently, many studies have focused on exploring in silico approaches in the identification and development of alternative therapy for the treatment and management of cancer. Solute carrier family-2-member-4-gene (Slc2a4) which encodes glucose transporter 4 protein (GLUT4), has been identified as a promising therapeu...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19020386
更新日期:2018-01-28 00:00:00
abstract::Metal often causes delayed-type hypersensitivity reactions, which are possibly mediated by accumulating T cells in the inflamed skin, called irritant or allergic contact dermatitis. However, accumulating T cells during development of a metal allergy are poorly characterized because a suitable animal model is unavailab...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms17010087
更新日期:2016-01-12 00:00:00
abstract::In this paper, we used a Genotyping-by-Sequencing (GBS) approach to find and genotype more than 4000 genome-wide SNPs (Single Nucleotide Polymorphisms) from striped killifish exposed to a variety of polychlorinated biphenyls (PCBs) and other aromatic pollutants in New Bedford Harbor (NBH, Massachusetts, USA). The aims...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20051129
更新日期:2019-03-05 00:00:00
abstract::Glucose-6-phosphate dehydrogenase (G6PD) deficiency in humans causes severe disease, varying from mostly asymptomatic individuals to patients showing neonatal jaundice, acute hemolysis episodes or chronic nonspherocytic hemolytic anemia. In order to understand the effect of the mutations in G6PD gene function and its ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17050787
更新日期:2016-05-21 00:00:00
abstract::The adhesion behavior of human tissue cells changes in vitro, when gravity forces affecting these cells are modified. To understand the mechanisms underlying these changes, proteins involved in cell-cell or cell-extracellular matrix adhesion, their expression, accumulation, localization, and posttranslational modifica...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21051749
更新日期:2020-03-04 00:00:00
abstract::DNA gyrases are enzymes that control the topology of DNA in bacteria cells. This is a vital function for bacteria. For this reason, DNA gyrases are targeted by widely used antibiotics such as quinolones. Recently, structural and biochemical investigations identified a new class of DNA gyrase inhibitors called NBTIs (i...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19020453
更新日期:2018-02-03 00:00:00
abstract::Osteosarcoma is the most common primary malignant bone tumour in children and adolescents. Due to micrometastatic spread, radical surgery alone rarely results in cure. Introduction of combination chemotherapy in the 1970s, however, dramatically increased overall survival rates from 20% to approximately 70%. Unfortunat...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21186885
更新日期:2020-09-19 00:00:00
abstract::The antifungal activity of polygodial, a secondary metabolite extracted from Canelo, on mycelial growth of different Botrytis cinerea isolates has been evaluated. The results show that polygodial affects growth of normal and resistant isolates of B. cinerea with EC50 values ranging between 117 and 175 ppm. In addition...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18112251
更新日期:2017-10-27 00:00:00
abstract::Some studies have ascribed a protective effect against neurodegenerative diseases to the β-carbolines harman (H) and norharman (NH), which occur mostly in coffee and coffee substitutes. We determined the concentrations of β-carbolines and undesirable compounds (such as acrylamide) in roasted coffee substitute ingredie...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21155245
更新日期:2020-07-24 00:00:00
abstract::Prostate cancer is widely observed to be biologically heterogeneous. Its heterogeneity is manifested histologically as multifocal prostate cancer, which is observed more frequently than unifocal prostate cancer. The clinical and prognostic significance of either focal cancer type is not fully established. To investiga...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms140611816
更新日期:2013-06-03 00:00:00
abstract::In this report, the use of fluorescence detection coupled capillary electrophoresis (CE-FL) allowed us to fully characterize the antigen-antibody interaction. CE-FL allowed separation of unbound quantum dots (QDs) and ligand bound QDs and also revealed an ordered assembly of biomolecules on QDs. Further, we observed F...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms140919146
更新日期:2013-09-17 00:00:00
abstract::Clinical conditions leading to chronic pain show important sex-related differences in the prevalence, severity, and degree of functional disability. Decades of epidemiological and clinical studies have demonstrated that women are more sensitive to pain than men. Arthritis, including rheumatoid arthritis (RA) and osteo...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21217938
更新日期:2020-10-26 00:00:00
abstract::Esophageal cancer remains a challenging disease due to limited treatment options and poor prognosis. In recent years, immune checkpoint inhibitors (ICI) have been proven to be safe and effective in the treatment of highly lethal malignancies, such as non-small cell lung cancer and melanoma. Recent clinical trials also...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21051658
更新日期:2020-02-28 00:00:00