Abstract：
OBJECTIVE:To determine the utility of CSF Xpert MTB/RIF (GeneXpert) in diagnosis of tubercular meningitis in children in the age group of 2 mo to 12 y. METHODS:This hospital based prospective observational study was conducted at Department of Pediatrics, Karnataka Institute of Medical Sciences (KIMS), Hubli from December 2015 through November 2016. All children with clinically suspected tuberculous meningitis (TBM) were included in the study. These children underwent a detailed history taking, clinical examination, blood investigations, lumbar puncture and CT brain. Cerebrospinal fluid (CSF) samples were sent for CSF GeneXpert examination. Statistical analysis was done using IBM SPSS Statistics Version 20. RESULTS:A total of 28 children were enrolled in the study. Six (21.4%), 4 (14.3%) and 18 (64.3%) cases were definite, probable and possible TBM cases respectively. Most common age group affected was <5 y (83.33%) with median age 2.5 y (IQR 4.875). Male:female ratio was 1.5:1. CSF GeneXpert was tested positive in 6 cases (21.4%). The sensitivity of the test against the clinical scoring (>/=10) was 46.15% (95% CI, 19.22-74.87) and specificity was 100% (95% CI, 78.20-100). There was a significant association between CSF GeneXpert and Mantoux test (P = 0.002), CSF cell type >50% lymphocytes (P = 0.005) and CSF protein >100 mg/dl (P = 0.025) along with CT hydrocephalus (P = 0.021), granuloma (P = 0.009) and basal exudates (P = 0.025). None of the cases were tested smear positive for acid-fast bacilli (AFB). CONCLUSIONS:CSF GeneXpert is superior to smear for AFB in TBM.
journal_name
Indian J Pediatrjournal_title
Indian journal of pediatricsauthors
A J,Ratageri VH,Illalu S,Fattepur SR,Wari PKdoi
10.1007/s12098-019-03032-0subject
Has Abstractpub_date
2019-12-01 00:00:00pages
1089-1093issue
12eissn
0019-5456issn
0973-7693pii
10.1007/s12098-019-03032-0journal_volume
86pub_type
杂志文章abstract：OBJECTIVE:The present study aimed to estimate the prevalence of acute diarrhea and its correlates in remote rural villages of south Pakistan. METHODS:The authors selected 1878 children less than 3 years of age through stratified random sampling from 64 villages having the number of children enrolled proportionate to t...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
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abstract：:Teratomas form the most common type of congenital brain tumors, frequently presenting as stillbirth. The largest neonatal series of intracranial teratomas reported a 12% survival rate. Although the first teratoma of the lateral ventricle was reported in 1961 by Maier, neonatal intracranial teratoma of the lateral vent...
journal_title：Indian journal of pediatrics
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journal_title：Indian journal of pediatrics
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journal_title：Indian journal of pediatrics
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更新日期：2006-06-01 00:00:00
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journal_title：Indian journal of pediatrics
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journal_title：Indian journal of pediatrics
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更新日期：2003-04-01 00:00:00
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journal_title：Indian journal of pediatrics
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更新日期：2013-06-01 00:00:00
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更新日期：2011-03-01 00:00:00
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journal_title：Indian journal of pediatrics
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journal_title：Indian journal of pediatrics
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更新日期：2005-06-01 00:00:00
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