Dyslipidemia in HIV Infected Children Receiving Highly Active Antiretroviral Therapy.

Abstract:

OBJECTIVE:To assess the prevalence of dyslipidemia and lipodystrophy in Indian children receiving non-nucleoside reverse transcriptase inhibitor (NNRTI) based highly active antiretroviral therapy (HAART) and to determine the associated risk factors for the same. METHODS:The present cross-sectional study was conducted at a Pediatric Clinic of a tertiary care teaching center in India, from May 2011 through December 2012. HIV infected children aged 5-15 y were enrolled if they did not have any severe disease or hospital admission within last 3 mo or receive any medications known to affect the lipid profile. Eighty-one children were on highly active antiretroviral therapy (HAART) for at least 6 mo and 16 were receiving no antiretroviral therapy (ART). Participants' sociodemographic, nutritional, clinical, and laboratory data were recorded in addition to anthropometry and evidence of lipodystrophy. Fasting lipid profile, apolipoprotein A1 and B levels were done for all the children. RESULTS:Among the children on highly active antiretroviral therapy (HAART), 38.3 % had dyslipidemia and 80.2 % had lipodystrophy, while 25 % antiretroviral therapy (ART) naïve HIV infected children had dyslipidemia. No clinically significant risk factors could be identified that increased the risk of dyslipidemia or lipodystrophy in children on highly active antiretroviral therapy (HAART). CONCLUSIONS:There is a high prevalence of dyslipidemia and lipodystrophy in Indian children with HIV infection with an imminent need to establish facilities for testing and treatment of these children for metabolic abnormalities.

journal_name

Indian J Pediatr

authors

Mandal A,Mukherjee A,Lakshmy R,Kabra SK,Lodha R

doi

10.1007/s12098-015-1859-3

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

226-31

issue

3

eissn

0019-5456

issn

0973-7693

pii

10.1007/s12098-015-1859-3

journal_volume

83

pub_type

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