Abstract：
OBJECTIVE:To evaluate the post treatment changes in disease activity and inflammatory markers over time in longitudinal follow-up involving different subtypes of juvenile idiopathic arthritis (JIA) patients. METHODS:This prospective longitudinal study, carried out over a period of 2 y, included JIA patients, both old and new, with high disease activity. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), ferritin, CHAQ (Childhood Health Assessment Questionnaire) score and JADAS27 (Juvenile Arthritis Disease Activity score with 27 active joint counts) were estimated at the initial visit, 6 mo, 12 mo and 18 mo of follow-up. RESULTS:Out of 40 patients, 10 had persistent oligoarthritis, 11 had rheumatoid factor (RF) positive polyarthritis, 8 had RF negative polyarthritis and 11 had systemic JIA. Twenty-one of them were females. Serum ferritin was highly elevated in systemic JIA patients with a range of 750-7712 ng/ml at the initial visit. All three inflammatory markers with disease activity score decreased significantly over 18-mo-period in all four subtypes. At any visit, all these parameters had largest value in systemic arthritis and least in oligoarthritis variety. At 18 mo, all oligoarthritis and polyarthritis cases had low or inactive disease while none of the systemic JIA patients achieved inactive disease. Elevated ESR and serum ferritin was found in all at 18 mo. CRP normalized in some with low or moderate disease activity. CONCLUSIONS:Inflammatory markers and disease activity decreased in all subtypes of JIA with treatment without biologics. Acute phase markers often remain elevated in inactive disease state. Similarly, normal level of an inflammatory marker does not necessarily indicate absence of active disease.
journal_name
Indian J Pediatrjournal_title
Indian journal of pediatricsauthors
Sarkar S,Alam MM,Das G,Datta Sdoi
10.1007/s12098-017-2292-6subject
Has Abstractpub_date
2017-05-01 00:00:00pages
349-356issue
5eissn
0019-5456issn
0973-7693pii
10.1007/s12098-017-2292-6journal_volume
84pub_type
杂志文章abstract：OBJECTIVE:To conduct a community survey to understand the prevalence and type of developmental delay/disability among a representative state wide community sample of children below 3 y. METHODS:A state wide community based cross sectional survey was done with the help of the Integrated Child Development Services (ICDS...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-014-1579-0
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:To find out whether gDNA methylation can be used as a diagnostic/prognostic method for neonatal sepsis. METHODS:The study was conducted in the neonatal division of a tertiary care referral hospital. Fifty one newborns as cases and thirty seven newborns as controls were enrolled in the study. Using 5-mC DNA E...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-014-1574-5
更新日期：2015-04-01 00:00:00
abstract：:Common variable immunodeficiency (CVID) is a rare primary immunodeficiency disease characterized by hypogammaglobulinemia and recurrent bacterial infections especially in respiratory and gastrointestinal systems. The authors present here a case of CVID with uncommon gastrointestinal manifestation in the form of CVID e...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-011-0635-2
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:To assess the benefits of nutrition supplementation in children living with HIV (CLHIV). METHODS:A prospective observational study was carried out at antiretroviral therapy (ART)/pediatric centre of excellence (PCOE), Niloufer hospital for a period of one year in CLHIV (N = 164) aged 1 to 18 y referred to AR...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-015-1873-5
更新日期：2016-03-01 00:00:00
abstract：:Gastrointestinal tumours are rare in children and leiomyoblastoma of small intestine is still rarer. We report a case of leiomyoblastoma of small intestine in a child who presented with acute intestinal obstruction. ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02831363
更新日期：1998-11-01 00:00:00
abstract：:The estimated prevalence of food allergy amongst children in the west is around 6-8% but there is paucity of data in the Indian population. There is a complex interplay of environmental influences and genetic factors in the immuno-pathogenesis and manifestations of food allergy. A reliable thorough clinical history, c...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-017-2535-6
更新日期：2018-05-01 00:00:00
abstract：:Computers can help to liberate students from the burden of rote learning of facts and enhance the role of reason and imagination in the learning process. Arguably, the computers constitute the most important single resource ever to become available to the teachers and students since the invention of the printing press...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02843603
更新日期：1994-03-01 00:00:00
abstract：:Protein energy malnutrition leading to growth failure is an inevitable consequence of chronic liver disease in childhood. Although the precise pathophysiology is not understood considerable progress has been made in understanding the mechanisms of fat malabsorption and protein turnover in liver disease. There are many...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02761872
更新日期：1995-09-01 00:00:00
abstract：:Malignant tumours of the chest wall are rare in the pediatric age group. Askin tumour, a primitive neuroectodermal tumour with aggressive nature, is extremely rare. Clinico-pathological features make it quite distinct from Ewing's sarcoma. Aggressive nature of the tumour results in short clinical presentation of the p...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02726235
更新日期：2000-11-01 00:00:00
abstract：:Stem cell transplantation and cord blood banking have received much popularity among general public and medical professionals in the recent past. But information about the scientific aspects, its utility and limitations is incomplete amongst laypersons as well as many medical practitioners. Stem cells differ from all ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-018-2651-y
更新日期：2019-01-01 00:00:00
abstract：:In India, child malnutrition is prevalent, especially among the poor and vulnerable. It is mostly the result of high levels of exposure to infection and inappropriate infant and young child feeding and caring practices, and it sets in mostly during the first 2 to 3y of life. Therefore, the present study was done to as...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-012-0894-6
更新日期：2013-12-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to determine if attention deficit and hyperactivity disorder (ADHD)/ learning disability (LD) adolescents are more prone to accidents and to investigate the parental mode of coping with that risk. METHODS:One hundred and eight high school pupils diagnosed with ADHD/LD and studying in...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02825823
更新日期：2006-04-01 00:00:00
abstract：:A 29 day old male infant presented with a history of fever, cough, increasing respiratory distress and abdominal distension from the 10th day of life. Examination revealed failure to thrive, marked tachypnea, pallor, hepatosplenomegaly and harsh vesicular breath sounds. Chest skiagram showed extensive broncho-pneumoni...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02752376
更新日期：1999-01-01 00:00:00
abstract：:Intolerance to foods which contain lactose can cause a range of intestinal and systemic symptoms. These symptoms are caused by Lactase deficiency which is encoded by a single gene (LCT) of ≈ 50 kb located on chromosome 2q21. In some food items, lactose has been missed because of "hidden" lactose due to inadequately la...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-014-1346-2
更新日期：2014-09-01 00:00:00
abstract：:The leukodystrophies are familial disorders with onset usually in infancy or childhood. The clinical features consist of motor dysfunction with varying degree of cognitive decline. Magnetic Resonance Imaging (MRI) has helped to identify and characterize these disorders. In some leukodystrophies, biochemical enzymatic ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02724013
更新日期：2005-04-01 00:00:00
abstract：:Celiac disease may present as a cryptogenic liver disorder being found in 5-10 % of patients with a persistent and cryptogenetic elevation of serum aminotransferase activity. In fact, a wide spectrum of liver injuries in children and adults may be related to CD and in particular: (1) a mild parenchymal damage characte...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02790391
更新日期：2006-09-01 00:00:00
abstract：:Anti-fungal agents are classified under two major headings, systematic and topical agents. Only systematic anti-fungal agents will be discussed in this chapter. Since the discovery in 1955, amphotericin B has been the cornerstone of anti-fungal treatment. It is active against most species of fungi. However, Candida lu...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02752281
更新日期：2001-07-01 00:00:00
abstract：:Distinction between true and pseudo trail in lumbo-sacral region is important since treatment and prognosis are different. Fewer than 40 cases have been reported in literature. The authors report a case of true tail in a neonate, a rare event. ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：
更新日期：2005-02-01 00:00:00
abstract：OBJECTIVE:Nasopharyngeal colonization of Haemophilus influenzae (H. influenzae) in young children may be important in developing countries. METHOD:In this study, we screened school going children for carriage of H. influenzae. A total of 44 H. influenzae isolates out of a collection of 162 were characterized for bioty...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02723690
更新日期：2002-09-01 00:00:00
abstract：:Iron overload is a serious and potentially fatal condition that results from multiple blood transfusions required over a long period of time to treat certain types of anemias such as, that caused by beta-thalassemia, sickle cell disease and myelodysplastic syndrome. Deferoxamine, which has been used since four decades...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-010-0030-4
更新日期：2010-02-01 00:00:00
abstract：:The abundant supply of recombinant growth hormone has raised interesting possibilities of several new applications. While supplementation of the missing hormone in patients with growth hormone deficiency is still the undisputed primary indication for its use, there is now convincing evidence of its usefulness in the t...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02752434
更新日期：1997-03-01 00:00:00
abstract：:Till forty years ago infants and children with hydrocephalus had a bleak future. Most of them used to die. Those who survived lived with mental retardation, spasticity and blindness. With the advent of an effective shunting device in 1957, a new era was ushered in the history of hydrocephalus. Today an infant with hyd...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：
更新日期：1997-11-01 00:00:00
abstract：:Children who had undergone adenotonsillectomy for recurrent adenotonsillitis showing no signs of clinical or radiological obstructive manifestations were evaluated with pulmonary function tests before, and one month after the operation. In relation to the result obtained by function tests, 60% of 45 cases (27) had the...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02822185
更新日期：1993-03-01 00:00:00
abstract：:While Allergic bronchopulmonary aspergillosis (ABPA) is known to complicate asthma in adults, its association with childhood asthma is very rare. We present two patients, a four-and half year old boy who presented with severe asthma and a 12 year-old girl whose previous chest radiographs revealed fleeting opacities. B...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-009-0020-6
更新日期：2009-03-01 00:00:00
abstract：:A two-and-a-half-year-old male child presented with recurrent attacks of intractable vomiting, psychomotor retardation since 14 months of age. He had also lower cranial nerve palsy and corticospinal involvement. Magnetic resonance imaging had shown multiple well circumscribed areas of hypointusity in T1 weighted image...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02730822
更新日期：1996-09-01 00:00:00
abstract：OBJECTIVE:To find out correlation between serum anti-tissue transglutaminase immunoglobulin-A (tTGA) levels and Marsh grading on duodenal histopathology in Celiac disease (CD). METHODS:In a prospective cohort study, a total of 52 symptomatic patients between age group of 2-18 y were enroled. All enroled patients were ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-017-2323-3
更新日期：2017-07-01 00:00:00
abstract：OBJECTIVE:To evaluate genetic variations of innate immune system such as mannose binding lectin (MBL), Toll like receptor 4 (TLR4), CD14, LY96 (MD2) and Uroplakin 1B (UPK1B) genes in children with recurrent urinary tract infection (UTI). METHODS:The study included 30 children with recurrent UTI and 30 healthy controls...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-011-0399-8
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVE:To compare cultures throat swab after physiotherapy with results of sputum culture in identification of lower airway pathogens in children with cystic fibrosis. METHODS:387 samples of sputum cough swabs, throat swab and throat swab after physiotherapy were collected from 48 patients of cystic fibrosis and cu...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02725650
更新日期：2004-01-01 00:00:00
abstract：:This study reports the clinical picture and measles virus antibody titres in 32 patients with cases of suspected subacute sclerosing panencephalitis (SSPE). The history of myoclonic jerks, mental regression, inability to walk and slurred speech, were noted in these cases. The EEG showed generalised periodic complexes ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02825445
更新日期：1991-11-01 00:00:00
abstract：:Hypertransfusion and regular chelation therapy have allowed improved survival in patients with thalassemia major (TM). Despite medical advances, growth failure and hypogonadism remain significant clinical problems in these patients in adolescence. Disproportionate truncal shortening which is common especially among ad...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02760702
更新日期：2005-02-01 00:00:00
