Abstract：
:Hypertransfusion and regular chelation therapy have allowed improved survival in patients with thalassemia major (TM). Despite medical advances, growth failure and hypogonadism remain significant clinical problems in these patients in adolescence. Disproportionate truncal shortening which is common especially among adolescents with thalassemia, is due to platyspondyly resulting from a combination of factors like hemosiderosis, desferrioxamine toxicity or deficiency of trace elements. Although growth hormone (GH) deficiency and GH neurosecretory dysfunction have been described in TM patients, most short TM patients have normal GH reserve. The low serum IGF-1 and IGFBP-3 concentrations in TM patients despite having normal GH reserve and serum GH binding protein levels suggest that a state of secondary GH insensitivity exists. The pubertal growth spurt may be impaired in TM patients going through spontaneous or induced puberty and may have a negative effect on final adult height. GH therapy in dosages ranging from 0.5-1.0 IU/kg/wk has resulted in a significant improvement in growth velocity in short TM children without any adverse effects on skeletal maturation, blood pressure, glucose tolerance and serum lipids. There is limited evidence that GH treatment can result in an improved final adult height in short TM children. Careful and regular clinical and biochemical monitoring should be preformed on these patients while they are treated with GH.
journal_name
Indian J Pediatrjournal_title
Indian journal of pediatricsauthors
Low LCdoi
10.1007/BF02760702keywords:
subject
Has Abstractpub_date
2005-02-01 00:00:00pages
159-64issue
2eissn
0019-5456issn
0973-7693journal_volume
72pub_type
杂志文章,评审abstract：:It is common for primary care physicians to be faced with children with hematological disorders in everyday practice. The article seeks to provide realistic information for the first-contact physician in handling common hematological diseases in children. Practical step-wise approach to understanding and investigating...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-013-1159-8
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:To compare cultures throat swab after physiotherapy with results of sputum culture in identification of lower airway pathogens in children with cystic fibrosis. METHODS:387 samples of sputum cough swabs, throat swab and throat swab after physiotherapy were collected from 48 patients of cystic fibrosis and cu...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02725650
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVE:Of this pilot study was to assess the iron status and dietary intake of 1-3 year-old apparently healthy toddlers of the lower socio-economic class, and the effect of eight weeks intervention with liquid oral iron in an urban slum in Pune, India. METHODS:50 toddlers (M= 25, F= 25) with mean age of 2.4 years (...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-008-0038-1
更新日期：2008-04-01 00:00:00
abstract：OBJECTIVE:Jaundice is a common clinical problem in neonatal period which may result in brain damage even in healthy full term newborns, when it is severe. The aim of this study was to characterize the therapeutic effect of clofibrate in full term neonates who present with nonhemolytic jaundice. METHODS:A clinical cont...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12098-007-0184-x
更新日期：2007-11-01 00:00:00
abstract：:Clinical retinopathy eventually develops in the majority of insulin dependent diabetics during several decades of metabolic abnormality. Early structural lesions short of clinical significance may occasionally be detected in children much more frequently, however, after puberty. Major factors modulating the developmen...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02776473
更新日期：1989-11-01 00:00:00
abstract：: ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-018-2720-2
更新日期：2019-01-01 00:00:00
abstract：:Growth monitoring and nutritional assessment, as means to detect malnutrition, are 2 different types of programs in terms of conception, purposes, and execution. Growth monitoring starts as detection of malnutrition, then acts through prevention by communication to mothers, and finally utilizes community participatio...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02810383
更新日期：1988-01-01 00:00:00
abstract：:The natural history of the univentricular physiology is determined primarily by the presence (severity) or absence of obstruction to pulmonary blood flow and secondarily by the single ventricular cardiomyopathy that develops in response to chronic volume overload. Important obstruction to pulmonary blood flow will aff...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02760487
更新日期：2000-07-01 00:00:00
abstract：:Since the classic description of this disease by Harold Hirschsprung's. In 1886 just over a century ago, there has been a marked evolution in the diagnostic modalities, understanding of the pathophysiology, unraveling of genetic association and the treatment approach of this disease. Recent research on the molecular b...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02758486
更新日期：2000-08-01 00:00:00
abstract：:Castleman's disease is an atypical lymphoproliferative disorder having two types of presentation--the localized and the multicentric form. The localized form presents as a slowly growing mass with a relatively benign course. Multicentric Castleman's disease has a more aggressive clinical course with diffuse lymph node...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-007-0210-z
更新日期：2007-12-01 00:00:00
abstract：:Every 5 years the American Heart Association (AHA) updates the Guidelines for CPR and Emergency Cardiovascular Care (ECC). The ECC Guidelines 2000 incorporates all the current consensus of experts, from not only a variety of disciplines, but also a variety of countries and cultures and is evidence based. The new Guide...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：
更新日期：2003-03-01 00:00:00
abstract：OBJECTIVE:To review contemporary guidelines and therapies for pediatric cardiac arrest and discuss potential novel therapies. METHODS:Key articles and guidelines in the field were reviewed along with recent publications in the fields of neurointensive care and neuroscience germane to cerebral resuscitation. RESULTS:A...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-008-0117-3
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:To assess the efficacy of arginine vasopressin (AVP) as a rescue therapy in children with catecholamine refractory vasodilatory shock and its effect on various hemodynamic, clinical, and laboratory variables. METHODS:This prospective hospital based study was conducted from January 2008 through July 2008 at a...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-011-0557-z
更新日期：2012-04-01 00:00:00
abstract：: ...
journal_title：Indian journal of pediatrics
pub_type： 评论,社论,评审
doi：10.1007/s12098-019-02890-y
更新日期：2019-03-01 00:00:00
abstract：:Chronic Epididymitis is a relatively rare problem in boys and is often enigmatic in its etiology. It is often associated with urinary tract abnormalities in infants and prepubertal children. This report describes a rare and unusual case of a chronic epididymitis with acquired scrotal vasocutaneous urinary fistula in a...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-012-0740-x
更新日期：2013-05-01 00:00:00
abstract：OBJECTIVE:To report our experience before and after implementation of pediatric rapid response team (RRT) in pediatric wards of a tertiary care hospital in Pakistan. METHODS:An audit of RRT activity from December 2007 to August 2008 was conducted and reviewed patient diagnoses at the time of call placement, interventi...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-010-0032-2
更新日期：2010-03-01 00:00:00
abstract：:The clinical presentation of pseudohypoaldosteronism (PHA) mimics congenital adrenal hyperplasia (CAH). Poor response of the dehydration and electrolyte abnormalities to steroid therapy should make one suspect PHA. The treatment is supportive in the form of salt replacement and sodium resonium. We report a case of PHA...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02758269
更新日期：2006-01-01 00:00:00
abstract：:Advances in diagnosis and treatment along with improved supportive care have contributed to the current survival rates for pediatric malignancies. Recent concept of a truly "cured child" in pediatric oncology envisages not only a biological cure of the disease but a child on par with peers in growth and development ph...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02723807
更新日期：2003-10-01 00:00:00
abstract：OBJECTIVE:To enumerate the cases of intussusception in Chennai during 2012-2013, describe the clinical profile, outcomes of case management and highlight the importance of systematically collecting this data in lieu of rotavirus vaccine introduction in India. METHODS:Medical records of pediatric intussusception cases ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-016-2152-9
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVE:To assess the trends and outcomes in referrals of 'phimosis for circumcision' to a tertiary care pediatric surgical department. METHODS:This is a prospective study of 100 consecutive children of presumed phimosis referred for circumcision. They were assessed and classified by the senior author as having eith...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-009-0120-3
更新日期：2009-08-01 00:00:00
abstract：:We studied the auditory brainstem responses of 50 high risk neonates from NICU and compared with those of 25 normal neonates in order to determine the percentage of significant auditory impairment in NICU and correlated it to various risk factors. Infants with the risk factors of low birth weight, hyperbilirubinemia, ...
journal_title：Indian journal of pediatrics
pub_type： 临床试验,杂志文章
doi：10.1007/BF02725499
更新日期：1997-11-01 00:00:00
abstract：:During the last eight years a total of nine cases of isolated congenital coronary arteriovenous fistula (CAVF) have been diagnosed at our centre. Age of these patients ranged from 11 days to 22 years (mean 6.4 +/- 4.2 years). There were seven male and two female patients. Right and left coronary arteries were the site...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02762180
更新日期：2000-09-01 00:00:00
abstract：OBJECTIVE:To measure the economic output/input ratios for the various options of prevention of rheumatic fever/rheumatic heart disease (RF/RHD) and check the viability of primary prevention vis-à-vis secondary and tertiary preventions. METHODS:Cost accounting of the various prevention options was calculated for each v...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-007-0094-y
更新日期：2007-06-01 00:00:00
abstract：:Two cases of Wilson's disease with unusual features are reported. In one case neurological abnormality was the presenting feature without any clinical involvement of the liver. In the other case, neurologic manifestations were associated with rickets and cholelithiasis, a result of chronic hemolytic state. Apart from ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02830841
更新日期：2004-10-01 00:00:00
abstract：:Bone injuries during the process of delivery were studied among 34, 946 live born babies over a 11 period. There were 35 cases of bone injuries giving an incidence of 1 per 1,000 live births. Clavicle was the commonest bone fractured (45.7%) followed by humerus (20%), femur (14.3%) and depressed skull fracture (11.4%)...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02751901
更新日期：1994-07-01 00:00:00
abstract：:Anorectal malformations are one of the commonest anomalies in the new born. Major advances have been made in the last decade in operative techniques to reconstruct this abnormality. The final outcome in these babies is dependent on careful planning and operative intervention in the neonatal period. The purpose of this...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02726272
更新日期：1999-09-01 00:00:00
abstract：:A bleeding child is a cause of great concern and often, panic, for parents and pediatricians alike. Causes of bleeding could be trivial or secondary to an underlying bleeding disorder or a potentially serious systemic illness. Based on etiology, they can be categorized into disorders affecting platelets or the coagula...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-012-0918-2
更新日期：2013-05-01 00:00:00
abstract：OBJECTIVES:To review the literature for justification of thoracoscopic management of blebs in children. METHODS:PubMed database was reviewed for articles in English, Portuguese and Spanish using the key words "thoracoscopy", "bleb" and "child". Data was collected for age, gender, type of surgery performed, operating t...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-017-2485-z
更新日期：2018-04-01 00:00:00
abstract：:Biotin Thiamine responsive Basal Ganglia Disease (BTBGD) is a rare treatable autosomal recessive metabolic disorder caused by mutations in SLC19A3 gene. It usually presents with encephalopathy and dystonia; if not treated, can progress to quadriparesis and death. Two Indian siblings born to a consanguineous marriage p...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-017-2471-5
更新日期：2018-02-01 00:00:00
abstract：:Laboratory investigations are an integral part of evaluation of a child with rheumatic disease. In rheumatic diseases markers of inflammation like CRP and erythrocyte sedimentation are usually raised. In addition, various autoantibodies like anti-nuclear antibody, rheumatoid factor, anti-neutrophil cytoplasmic antibod...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02723714
更新日期：2002-10-01 00:00:00
