Abstract:
OBJECTIVE:To review contemporary guidelines and therapies for pediatric cardiac arrest and discuss potential novel therapies. METHODS:Key articles and guidelines in the field were reviewed along with recent publications in the fields of neurointensive care and neuroscience germane to cerebral resuscitation. RESULTS:A total of 45 articles were reviewed. The majority of arrests in the pediatric population are asphyxial in origin--which differs importantly from the adult population. The International Consensus on CPR guidelines are discussed, including good quality CPR, chest compressions without interruptions, resuscitation with 100% oxygen and subsequent titration of oxygen to normal oxygen saturations, correct dose of epinephrine, and use of hypothermia in the first 12-24 hours. Novel therapies that showed success in animal studies, such as hypertensive reperfusion, thrombolytics, hemodilution and extracorporeal CPR are also discussed. CONCLUSION:With only 30% return of spontaneous circulation, 12% survival to hospital discharge and 4% intact neurologic survival, pediatric cardiac arrest remains an area of intense research for therapies to improve its outcomes. In addition to the rapid implementation of basic and advanced life support interventions, new therapies that may have value include mild hypothermia, extracorporeal support, promotion of cerebral blood flow and other more novel therapies targeting oxidative stress, excitotoxicity, neuronal death, and rehabilitation.
journal_name
Indian J Pediatrjournal_title
Indian journal of pediatricsauthors
Manole MD,Hickey RW,Clark RS,Kochanek PMdoi
10.1007/s12098-008-0117-3subject
Has Abstractpub_date
2008-06-01 00:00:00pages
609-14issue
6eissn
0019-5456issn
0973-7693journal_volume
75pub_type
杂志文章,评审abstract:OBJECTIVE:The aim of this study is to assess the effect of diagnosis of cancer on the parents, to study the coping response adopted by the child and the family and to evolve counseling strategies. METHODS:Prospective questionnaire based. Thirty-four parents of children suffering from cancer were included, of which 15 ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-007-0149-0
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:Hirschsprung's disease may be associated with a number of congenital anomalies of which Down's syndrome and intestinal atresias are commonly encountered. The study aimed to assess the impact of rare associated anomalies on the diagnosis and management of Hirschsprung's disease. METHODS:A retrospective review...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02762106
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVE:Suicide among youth is of great concern and a subject requires thorough study to formulate prevention strategy. In this paper the incidence and trends of suicide among children and adolescent of South Delhi have been reported. METHODS:A retrospective analysis was carried out on 222 cases of suicidal deaths p...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02730657
更新日期:2004-08-01 00:00:00
abstract::Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are disorders of pulmonary inflammation characterized by hypoxemia and respiratory failure. Children have varying incidence of ALI/ARDS from 2.2 to 16 per 100,000 pediatric population associated with high morbidity, mortality, and financial burden....
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-010-0169-z
更新日期:2010-11-01 00:00:00
abstract::Helicobacter pylori is one of the commonest bacterial pathogens in human. The organism is associated with development of peptic ulcer diseases, lymphoproliferative disorders and gastric cancer. Residence in a developing country, poor socio-economic conditions and genetic predisposition are regarded as risk factors. Pr...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-007-0046-6
更新日期:2007-03-01 00:00:00
abstract::Moebius syndrome is characterized by congenital complete or partial facial nerve palsy with or without paralysis of cranial nerves and often associated with other malformations. Cardiac anomalies though known are very rare and till date only 4 cases have been reported. We present a case of Moebius syndrome with suprac...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02758568
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:To find out correlation between serum anti-tissue transglutaminase immunoglobulin-A (tTGA) levels and Marsh grading on duodenal histopathology in Celiac disease (CD). METHODS:In a prospective cohort study, a total of 52 symptomatic patients between age group of 2-18 y were enroled. All enroled patients were ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-017-2323-3
更新日期:2017-07-01 00:00:00
abstract::Frank-Ter Haar syndrome is an unusual type of skeletal dysplasia with megalocornea and developmental delay. It is usually transmitted as autosomal recessive disorder. Only a few cases have been reported in the literature and none from India. The authors report a case with other unusual features and a short review of t...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-011-0599-2
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:To find out various life stressors of adolescents, coping strategies adopted by them and the impact of stress on adolescent mental health. METHODS:A descriptive, cross sectional study was conducted in the schools in south zone of Delhi, capital city of the country. Data was collected on 360 adolescents betwe...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-015-1710-x
更新日期:2015-09-01 00:00:00
abstract::We present a preterm neonate who developed congenital rubella syndrome in a mother who had rubella at 5 months of gestation. An amniocentesis was done in the mother at that time but amniotic fluid rubella PCR was negative. Thus, inspite of prenatal screening, one cannot definitely conclude absence of perinatal transmi...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-009-0312-x
更新日期:2010-04-01 00:00:00
abstract::Congenital heart diseases have varied presentations depending on the age of presentation. Regression of neonatal pulmonary hypertension and the timing of establishment of left to right shunt determines the onset of symptoms. Pre-tricuspid shunts generally remain asymptomatic during the childhood while large post-tricu...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-020-03251-w
更新日期:2020-05-01 00:00:00
abstract::Four patients from a Muslim family with an inherited skeletal dysplasia are presented. It is more crippling than usual form of spondylo-epiphysial dysplasia tarda and the onset is very early in the life i.e. at 4 years. The disorder is progressive, crippling and has striking clinical resemblance to juvenile rheumatoid...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02722278
更新日期:1990-11-01 00:00:00
abstract::Stem cell transplantation and cord blood banking have received much popularity among general public and medical professionals in the recent past. But information about the scientific aspects, its utility and limitations is incomplete amongst laypersons as well as many medical practitioners. Stem cells differ from all ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-018-2651-y
更新日期:2019-01-01 00:00:00
abstract::Nutrition plays a vital role in maintaining and enhancing the health of an individual. As mortality within intensive care units declines because of increased expertise and better equipment, attention is being focused on better methods of feeding the critically ill child. Feeding the child is one aspect that has been r...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF02721839
更新日期:2001-04-01 00:00:00
abstract::Eighty-seven patients with pectus excavatum underwent cardiac examination and echocardiography (M-mode) to determine the diagnostic significance of pectus in children for mitral valve prolapse (MVP). Patients' ages ranged from 1 month to 18 years with a mean age of 5.4 years. Sixty-seven were males. Twenty of the 87 p...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02722092
更新日期:1990-03-01 00:00:00
abstract:OBJECTIVES:To investigate factors involved in causing hypocalcemia in critically ill patients. METHODS:The patients aged 1 mo to 18 y, admitted to PICU at Nemazee Hospital, from May through November 2012, were reviewed. Those with impaired calcium hemostasis or on vitamin-D supplement were excluded. Calcitonin and par...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-014-1536-y
更新日期:2015-03-01 00:00:00
abstract::Castleman's disease is an atypical lymphoproliferative disorder having two types of presentation--the localized and the multicentric form. The localized form presents as a slowly growing mass with a relatively benign course. Multicentric Castleman's disease has a more aggressive clinical course with diffuse lymph node...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-007-0210-z
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVES:To identify the problems faced by parents of children with developmental disabilities in availing rehabilitative services and to find their satisfaction level. METHODS:This study was carried out at a Child Development Clinic (CDC) located in Northern India. Children with developmental disabilities, who were...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-011-0653-0
更新日期:2012-09-01 00:00:00
abstract::In India, child malnutrition is prevalent, especially among the poor and vulnerable. It is mostly the result of high levels of exposure to infection and inappropriate infant and young child feeding and caring practices, and it sets in mostly during the first 2 to 3y of life. Therefore, the present study was done to as...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-012-0894-6
更新日期:2013-12-01 00:00:00
abstract::In order to evaluate all the important limbs of the immune system in the same patient population with rheumatic fever (RF) and rheumatic heart disease (RHD) cellular and humoral immune parameters as well as the immunogenetic profile in 265 North Indian patients with RHD were evaluated. They were studied for class in H...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02728716
更新日期:1990-09-01 00:00:00
abstract:OBJECTIVES:To determine the incidence, etiology and outcome of Cardiorenal syndrome (CRS) in hospitalized children. METHODS:A prospective cohort study was carried out in 242 children between 6 mo to 18 y of age hospitalized with primary cardiac, renal or any systemic disorder at a tertiary care center in India. The pr...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-017-2307-3
更新日期:2017-06-01 00:00:00
abstract::Incontinentia Pigmenti is a rare neurocutaneous disorder that may present with neurological symptoms in early infancy in addition to characteristic skin rashes. We report a two-mo-old girl presenting with a rash and encephalopathy. Magnetic resonance imaging of brain showed hemorrhagic infarcts. First we thought baby ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-012-0916-4
更新日期:2013-11-01 00:00:00
abstract::The renal tubule plays an important role in fluid and electrolyte homeostasis. Renal tubular disorders may affect multiple ( e.g., Fanconi syndrome) or specific (e.g., nephrogenic diabetes insipidus, renal glucosuria) tubular functions. Most conditions are primary and monogenic but occasionally are secondary to other ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF02734150
更新日期:2005-09-01 00:00:00
abstract::Psychosocial and mental health problems are quite prevalent among adolescent worldwide, some data reporting up to 20% of adolescents having such problems. A number of risk factors, familial, individual and societal, have been indentified as contributing to these problems in adolescents. There are also many factors, su...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02723793
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVES:In this pilot study, the authors developed and evaluated a working memory intervention (WMI) using a combination of mobile phone-based application and an activity booklet, among children with idiopathic generalized epilepsy. METHODS:Pre- and post-intervention cognitive evaluation at 8 wk included: subtests ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-020-03653-w
更新日期:2021-01-09 00:00:00
abstract::A review is presented on the care of three diabetic emergencies: diabetic ketoacidosis (DKA), hypoglycemias and sick days. A treatment scheme, based on low-dose insulin regime and i.v. insulin administration is presented. Plenty of emphasis is laid on fluid and electrolyte therapy. It is stressed that the primary goal...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02776468
更新日期:1989-11-01 00:00:00
abstract:OBJECTIVE:To explore the independent role of age at menarche on menstrual abnormalities among adolescents. METHODS:The present study was a multicenter cross-sectional study on a large sample (n = 3782) of Italian girls aged 13-21 y attending secondary school who already had menarche. Girls were asked to fill in a ques...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-018-2822-x
更新日期:2019-01-01 00:00:00
abstract::Neonates are among those patients generating the highest hospital costs in recent years. There are no published data on the costs of neonatal intensive care in our country. The aim of our study was to analyse the cost of neonatal intensive care in a tertiary care unit. The average hospital charges per day were higher ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02752301
更新日期:1998-03-01 00:00:00
abstract::Skeletal dysplasia are a relatively common and distinct group of genetic disorders. Even though abnormalities of bone growth are the major clinical manifestations, the pathological process may involve in any body system. Many of these disorders have dire consequences such as neonatal death and most will have life-long...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02723957
更新日期:2000-12-01 00:00:00
abstract::Every 5 years the American Heart Association (AHA) updates the Guidelines for CPR and Emergency Cardiovascular Care (ECC). The ECC Guidelines 2000 incorporates all the current consensus of experts, from not only a variety of disciplines, but also a variety of countries and cultures and is evidence based. The new Guide...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:2003-03-01 00:00:00