Abstract:
:In order to evaluate all the important limbs of the immune system in the same patient population with rheumatic fever (RF) and rheumatic heart disease (RHD) cellular and humoral immune parameters as well as the immunogenetic profile in 265 North Indian patients with RHD were evaluated. They were studied for class in HLA antigens and 165 of them were also evaluated for the class II (DR locus) antigen profile. Data obtained was compared with 400 and 134 healthy controls respectively of the same ethnicity. Humoral immune parameters (Serum immunoglobulins IgG, IgA; Serum complement fractions C3, C4, C3d; circulating immune complexes and B lymphocyte numbers) and cellular immune parameters (total leucocyte and lymphocyte counts; T lymphocyte sub-populations--CD4, CD8 counts; lymphocyte migration inhibition to an extracellular streptococcal antigen, streptolysin 'O') were studied in 23 patients with RF, 21 patients with "inactive" RHD and 20 normal controls. Patients of RHD were noted to have an increased frequency of DR3 (P less than 0.001; Relative risk = 2.3) and a decreased frequency of DR2 (P less than 0.001; Relative risk = 0.3) as compared to the controls. Patients of RF had evidence of an altered regulatory T cell function (increased CD4/CD8 ratio) and decreased cell mediated immunity to streptolysin 'O'. An increased humoral immune response (increased B cell counts, elevated serum IgG, circulating immune complexes and C3d) was noted in patients of RF as well as "inactive" RHD. An integrated pathogenetic model with immune response associated antigens of the DR locus influencing selection of cardiac cross-reactive antigens by the antigen processing macrophages, an altered regulatory T cell function with decreased suppressor T cell activity leading to an abnormal immune response is proposed to explain the pathogenesis of RF.
journal_name
Indian J Pediatrjournal_title
Indian journal of pediatricsauthors
Reddy KS,Narula J,Bhatia R,Shailendri K,Koicha M,Taneja V,Jhingan B,Pothineni RB,Malaviya AN,Mehra NKdoi
10.1007/BF02728716subject
Has Abstract,Author List Incompletepub_date
1990-09-01 00:00:00pages
693-700issue
5eissn
0019-5456issn
0973-7693journal_volume
57pub_type
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-014-1521-5
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abstract:OBJECTIVE:To explore the independent role of age at menarche on menstrual abnormalities among adolescents. METHODS:The present study was a multicenter cross-sectional study on a large sample (n = 3782) of Italian girls aged 13-21 y attending secondary school who already had menarche. Girls were asked to fill in a ques...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-012-0687-y
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02723925
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
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更新日期:2007-08-01 00:00:00
abstract:OBJECTIVE:To compare tympanic membrane temperature and rectal temperature in febrile pediatric patients. METHODS:Sixty febrile children were enrolled as continuous enrollment at initial triage. Two readings of ear temperature were taken in each child with Thermoscan infrared thermometer. Rectal temperature was recorde...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02723215
更新日期:2002-04-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-012-0943-1
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-009-0098-x
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-014-1430-7
更新日期:2014-12-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF02849685
更新日期:1998-01-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02825490
更新日期:2006-03-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02725650
更新日期:2004-01-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02759893
更新日期:2006-06-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02724181
更新日期:2005-07-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-018-2623-2
更新日期:2018-03-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-019-03032-0
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02859281
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02723198
更新日期:2001-03-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-014-1574-5
更新日期:2015-04-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-011-0533-7
更新日期:2012-02-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,meta分析
doi:10.1007/s12098-019-03098-w
更新日期:2020-01-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-015-1792-5
更新日期:2015-12-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02722657
更新日期:2002-06-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-011-0399-8
更新日期:2011-10-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-014-1629-7
更新日期:2015-06-01 00:00:00