Abstract：
OBJECTIVE:To find out correlation between serum anti-tissue transglutaminase immunoglobulin-A (tTGA) levels and Marsh grading on duodenal histopathology in Celiac disease (CD). METHODS:In a prospective cohort study, a total of 52 symptomatic patients between age group of 2-18 y were enroled. All enroled patients were subjected to upper GI endoscopy by an experienced endoscopist. Two biopsies each from the bulb (D1) and second part (D2) of the duodenum were taken and Marsh grading was performed by a single experienced pathologist. Serum tTGA levels were also performed to find out correlation between serum tTGA levels and Marsh grading. RESULTS:The mean age of the patients was 8.21 ± 3.45 y (Range: 2-16 y). Anemia was the most common non-gastrointestinal (GI) sign and was present in 73% of the cases. However the authors could not find out any significant association between Marsh grading and hemoglobin levels (r = 0.32, p > 0.05). Serum tTGA levels were found to be positively correlated with Marsh grading (Spearmen correlation coefficient ρ = 0.74, p 0.000). Significant differences were found in tTGA levels between different Marsh gradings (ANOVA test) (p 0.000). Receiver-operator curve (ROC) analysis cut-off value of serum tTGA for predicting villous atrophy was 178.8 (nine times of cut-off value) with sensitivity of 100% and specificity of 85.7%. CONCLUSIONS:Serum tTGA levels can be used to predict villous atrophy and biopsy may be avoided in strongly suspected cases with more than 9 times of cut-offs.
journal_name
Indian J Pediatrjournal_title
Indian journal of pediatricsauthors
Jora R,Raghuvanshi V,Payal V,Sharma P,Vishnoi SKdoi
10.1007/s12098-017-2323-3subject
Has Abstractpub_date
2017-07-01 00:00:00pages
515-520issue
7eissn
0019-5456issn
0973-7693pii
10.1007/s12098-017-2323-3journal_volume
84pub_type
杂志文章abstract：:This article is our life time experience in conceptualizing and systematically developing Child Development Centre (CDC) Kerala in the last 25 years, from a research project to a national training centre in child and adolescent development and premarital counseling. CDC Kerala's major contribution was in creating a 'c...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-016-2071-9
更新日期：2016-05-01 00:00:00
abstract：OBJECTIVE:To develop a height and weight based equation to estimate total body water (TBW) in Sri Lankan children. METHODS:Cross sectional descriptive study done involving 5-15 year old healthy children. Height and weight were measured. TBW was assessed using isotope dilution method (D(2)O) and fat free mass (FFM) cal...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-009-0333-5
更新日期：2010-02-01 00:00:00
abstract：OBJECTIVE:To understand the causes of child deaths in order to implement appropriate child survival interventions in the country. We present a systematic review of studies reporting causes of child, infant, and neonatal deaths from India for 1985 to 2008. METHODS:PubMed, EMBASE, Google Scholar, and WHO regional databa...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-010-0246-3
更新日期：2010-11-01 00:00:00
abstract：:The term aseptic meningitis encompasses all types of inflammations of the brain meninges other than that caused by pus producing organisms. It is usually a benign illness. Etiology of aseptic meningitis is very wide and includes many infections - both viral and non viral, drugs, malignancy and systemic illness. The mo...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02760582
更新日期：2005-01-01 00:00:00
abstract：:Growth monitoring programs are often considered failures. These failures often stem from a lack of understanding of program implementation. The 10 most common pitfalls of the system are listed as follows: 1) Health workers tend to desire a diagnostic curative approach to malnutrition where Growth Monitoring and Pre...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02810384
更新日期：1988-01-01 00:00:00
abstract：:There is lack of data on outcome of limited stage pediatric non-Hodgkin lymphoma (NHL) from south Asia. In view of this lacuna, authors evaluated patients of early stage (stage 1 and 2) non-lymphoblastic pediatric NHL patients treated with uniform short course, reduced-intensity protocol from Jan 2003 through Dec 2016...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-017-2585-9
更新日期：2018-09-01 00:00:00
abstract：:The estimated prevalence of food allergy amongst children in the west is around 6-8% but there is paucity of data in the Indian population. There is a complex interplay of environmental influences and genetic factors in the immuno-pathogenesis and manifestations of food allergy. A reliable thorough clinical history, c...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-017-2535-6
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the antenatal profile of the mother and the immediate neonatal morbidity and mortality till discharge. METHODS:The study was a retrospective analysis of 92 patients of preterm labour who delivered babies weighing RESULTS:A total of 92 mothers in preterm labour at 26 to 34 weeks were admitted and...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02898441
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVES:To test the feasibility of adding a novel delayed intensification chemotherapy to a dose-intensive induction regimen chemotherapy for high-risk neuroblastoma. METHODS:Patients enrolled in this study received chemotherapy in accordance with the design of the NB97 trial. At the end of the therapy, patients re...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-018-2737-6
更新日期：2019-02-01 00:00:00
abstract：:Ultrasound (US) is a simple, non-invasive imaging modality which allows high-resolution imaging of the musculoskeletal (MSK) system. Its increasing popularity in pediatrics is due to the fact that it does not involve radiation, has an ability to visualize non-ossified cartilaginous and vascular structures, allows dyna...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-015-1957-2
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVES:Type 1 diabetes (T1D) adolescents often do not achieve good glycemic control. In the context of growing number of technologically savvy adolescents, this study was done to examine the effectiveness of a motivational smartphone app to improve their glycemic control. METHODS:Eleven to eighteen year old adoles...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-019-03035-x
更新日期：2019-12-01 00:00:00
abstract：:The present analytic study was planned to study the impact of overweight and obesity on glucose tolerance in adolescents. Thirty overweight (BMI analogue ≥ 25-29.9 kg/m(2)) and 30 obese (BMI analogue ≥ 30 kg/m(2)) adolescents were included as cases and 30 healthy age and sex matched adolescents comprised the contro...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-011-0456-3
更新日期：2011-11-01 00:00:00
abstract：:Functional follicular ovarian cysts are frequently reported in girls with peripheral precocious puberty (PP). These cysts are usually self-limiting and resolve spontaneously. Several drugs like antiestrogens (tamoxifen) and new aromatase inhibitors are seldom used for treatment. Here we report a girl with peripheral P...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-009-0190-2
更新日期：2009-09-01 00:00:00
abstract：OBJECTIVE:To determine the utility of CSF Xpert MTB/RIF (GeneXpert) in diagnosis of tubercular meningitis in children in the age group of 2 mo to 12 y. METHODS:This hospital based prospective observational study was conducted at Department of Pediatrics, Karnataka Institute of Medical Sciences (KIMS), Hubli from Decem...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-019-03032-0
更新日期：2019-12-01 00:00:00
abstract：:Pediatric heart failure (PHF) is an important cause of mortality and morbidity. Whereas ischemic heart disease is the most important cause of heart failure in adults, congenital heart diseases (CHD) and cardiomyopathies are important etiologies of PHF. Management of PHF also differs from that of adults. Here authors h...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-020-03255-6
更新日期：2020-04-01 00:00:00
abstract：OBJECTIVES:To study the magnitude and determinants of growth faltering among 0-6 y children in adopted villages of medical college. METHODS:A total 305 children of less than 6 y were followed monthly for 1 y to assess the growth faltering. At each visit, the mothers/caretakers of children were interviewed and informat...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-011-0582-y
更新日期：2012-03-01 00:00:00
abstract：:Neonatal care has made tremendous improvements in developing countries. However there are number of challenges to be met and neonatal mortality remains unacceptably high. In contrast to this neonatal care in developed nations have moved ahead of a pre-occupation to reducing the neonatal mortality only. The main reason...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-007-0011-4
更新日期：2007-02-01 00:00:00
abstract：OBJECTIVE:To study the iron profile and find out an accurate diagnostic tool which reflects iron status in different types of infection in severely malnourished children aged 12 months to 71 months. METHODS:Hundred and Eight (108) children of whom 72 children were infected and 36 non infected severely malnourished chi...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-009-0098-x
更新日期：2009-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of low dose vasopressin on the hemodynamics of neonates with persistent pulmonary hypertension and catecholamine refractory shock. METHODS:This retrospective study was conducted in a level III NICU of a tertiary care teaching hospital, south India. Eighteen neonates with hypoxemic resp...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-020-03519-1
更新日期：2020-10-08 00:00:00
abstract：:Fraser or Cryptophthalmos syndrome is a variable syndrome to the extent that cryptophthalmos might not be present in all cases. However, the main features are a "hidden eye", other craniofacial abnormalities, renal abnormalities, syndactyly and abnormal genitalia. It may be classified as isolated cryptophthalmos or cr...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02723939
更新日期：2000-10-01 00:00:00
abstract：OBJECTIVE:Of this pilot study was to assess the iron status and dietary intake of 1-3 year-old apparently healthy toddlers of the lower socio-economic class, and the effect of eight weeks intervention with liquid oral iron in an urban slum in Pune, India. METHODS:50 toddlers (M= 25, F= 25) with mean age of 2.4 years (...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-008-0038-1
更新日期：2008-04-01 00:00:00
abstract：OBJECTIVE:Heterosexual contact is the predominant mode of transmission among adults in India with an increasing number of women of childbearing age becoming infected with HIV. Consequently, children in India increasingly getting infected, primarily from vertical transmission. A retrospective review of the profile of HI...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02724249
更新日期：2003-08-01 00:00:00
abstract：OBJECTIVES:To review the literature for justification of thoracoscopic management of blebs in children. METHODS:PubMed database was reviewed for articles in English, Portuguese and Spanish using the key words "thoracoscopy", "bleb" and "child". Data was collected for age, gender, type of surgery performed, operating t...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-017-2485-z
更新日期：2018-04-01 00:00:00
abstract：:Kocher-Debre-Semelaigne syndrome is a rare association of muscular pseudohypertrophy and hypothyroidism in children. We report two cases of this syndrome in this communication. The first case was a seven-years-old female who presented with features of hypothyroidism and muscle pseudohypertrophy. The second child had s...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02724260
更新日期：2003-08-01 00:00:00
abstract：OBJECTIVE:To assess the treatment and outcome of children with acute myeloid leukemia. The Primary objectives were to assess remission rates, treatment related toxicity and disease free survival. Secondary objective was to assess prognostic factors associated with poor outcome. METHODS:A retrospective analysis of all ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-010-0300-1
更新日期：2011-10-01 00:00:00
abstract：:Distinction between true and pseudo trail in lumbo-sacral region is important since treatment and prognosis are different. Fewer than 40 cases have been reported in literature. The authors report a case of true tail in a neonate, a rare event. ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：
更新日期：2005-02-01 00:00:00
abstract：:Thirty children presenting with acute encephalopathic illness within a month of measles were studied. A male preponderance was found and 83.3% of cases were below 5 years of age. The interval between onset of measles rash and that of encephalopathy ranged from 0 to 20 days. Fever (96.6%), convulsions (70%), and coma (...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02722298
更新日期：1989-05-01 00:00:00
abstract：OBJECTIVE:To quantitatively summarize the evidence from observational studies on the relation between pediatric asthma and food allergy. METHODS:A literature search was conducted in Medline and EMBASE (August 2016). Two independent reviewers appraised the studies and extracted the estimates of interest. Methodological...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,meta分析
doi：10.1007/s12098-017-2326-0
更新日期：2017-08-01 00:00:00
abstract：:Pulmonary actinomycosis is rarely reported in pediatric age. An 11-year-old girl with history of two-month back pain was admitted to our hospital. On physical examination respiratory sounds were diminished on the left upper lung. Chest radiograph revealed a mass in the left upper lobe. Computed tomography showed solit...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-008-0233-0
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVE:Nosocomial infections are one of the most important causes of mortality and morbidity in hospitals. These are major public health problems worldwide, but particularly in developing countries. These infections have the most common frequency in pediatric hospitals-especially in neonatal wards- second to burn ho...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02825479
更新日期：2006-03-01 00:00:00
