Abstract：
OBJECTIVES:To test the feasibility of adding a novel delayed intensification chemotherapy to a dose-intensive induction regimen chemotherapy for high-risk neuroblastoma. METHODS:Patients enrolled in this study received chemotherapy in accordance with the design of the NB97 trial. At the end of the therapy, patients received three cycles of delayed intensification chemotherapy. The delayed intensification chemotherapy consists of two A1 and one A2 cycle. The A1 cycle consists of 1.5 mg/m2 of vincristine on day 1, 1.2 g/m2 of cyclophosphamide on day 2, 100 mg/m2 of cisplatin on day 3, and 160 mg/m2 of etoposide on day 4. The A2 cycle is similar to the A1 cycle, however the only difference is that on day 4, 30 mg/m2 of doxorubicin is substituted for etoposide. RESULTS:Between 2007 to 2011, a total of thirty-six patients were enrolled, sixteen patients were long term event-free survivors. Three patients were alive with tumor whilst fifteen patients died. The 3-year Event free survival (EFS) and Overall survival (OS) were 44.4% (95%CI, 27.4 to 61.5%) and 50% (95%CI, 32.8 to 67.2%) respectively. CONCLUSIONS:A high rate of survival among patients with high-risk neuroblastoma was achieved with delayed intensification chemotherapy without the occurrence of a second malignancy.
journal_name
Indian J Pediatrjournal_title
Indian journal of pediatricsauthors
Zhang YT,Chang J,Xu HM,Li YN,Zhong XD,Liu ZLdoi
10.1007/s12098-018-2737-6subject
Has Abstractpub_date
2019-02-01 00:00:00pages
126-131issue
2eissn
0019-5456issn
0973-7693pii
10.1007/s12098-018-2737-6journal_volume
86pub_type
杂志文章abstract：:The authors present a case of a preterm newborn with congenital infection of herpes simplex virus type 2. The patient was treated with newly recommended high intravenous doses of acyclovir. It can be supposed that it reduces mortality, but the high morbidity continues to be a problem. ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：
更新日期：2004-12-01 00:00:00
abstract：:Glial choristoma is a developmental malformation of heterotopic central nervous tissue with limited growth potential. It is considered to be one of the very rare choristomatous lesions involving the oral cavity. This report details the morphological characteristics of glial choristoma arising from the palate in a newb...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02722638
更新日期：2002-05-01 00:00:00
abstract：OBJECTIVE:To identify the burden of rotavirus acute gastroenteritis (AGE) and the genotypes presenting in the authors' area in the period after introduction of rotavirus vaccine in Universal Immunization Programme (UIP). METHODS:Children aged less than 5 y and presenting to hospital for the treatment of AGE were enrol...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-020-03606-3
更新日期：2021-01-29 00:00:00
abstract：:Lead poisoning is a preventable entity that can affect almost every system of the body. Its toxic effects range from subtle common childhood symptoms to even death. In a prospective study forty six children with at least one symptom compatible with plumbism were enrolled after screening patients attending medical serv...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02726170
更新日期：2000-02-01 00:00:00
abstract：:This article is an extensive review of current information available on the macrolide antibiotics. This includes antimicrobial spectrum, pharmacology, complications and side effects, and pediatric use of these drugs. These are important antibiotics, but careful selection of patients must be made and the physician must...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02849685
更新日期：1998-01-01 00:00:00
abstract：:Nosocomial infections in Pediatric Intensive Care Units (PICUs) caused by multidrug-resistant bacterial organisms are increasing. This review attempts to report on significant findings in the current literature related to nosocomial infections in PICU settings with an international perspective. The types of nosocomial...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-010-0253-4
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:To review contemporary guidelines and therapies for pediatric cardiac arrest and discuss potential novel therapies. METHODS:Key articles and guidelines in the field were reviewed along with recent publications in the fields of neurointensive care and neuroscience germane to cerebral resuscitation. RESULTS:A...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-008-0117-3
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:To determine pulmonary function abnormalities in children with Sickle Cell Disease (SCD) from Western India. METHODS:In this cross sectional study conducted at Surat, Gujarat, India; equal number of age and gender matched children i.e., 99 in the age group of 6-18 y was recruited in case (children with SCD) ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-016-2065-7
更新日期：2016-08-01 00:00:00
abstract：:Teratomas form the most common type of congenital brain tumors, frequently presenting as stillbirth. The largest neonatal series of intracranial teratomas reported a 12% survival rate. Although the first teratoma of the lateral ventricle was reported in 1961 by Maier, neonatal intracranial teratoma of the lateral vent...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-010-0039-8
更新日期：2010-04-01 00:00:00
abstract：OBJECTIVES:To establish a technique for mutation identification and prenatal screening in confirmed cases of Canavan disease. METHOD:Mutations in ASPA gene were identified by sequencing. Six exons of ASPA gene were amplified using intronic primers flanking the exons and then sequenced on ABI 3500Dx automated unit. Thi...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-012-0862-1
更新日期：2013-01-01 00:00:00
abstract：:Cryptosporidium is an intestinal protozoa known to cause diarrhea in animals and more recently has been recognised as a cause of diarrhea in humans. The present study was designed to determine the prevalence of cryptosporidium as a cause of diarrhea in children. Faecal samples of 180 children admitted to the hospital ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02749728
更新日期：1989-01-01 00:00:00
abstract：:A bleeding child is a cause of great concern and often, panic, for parents and pediatricians alike. Causes of bleeding could be trivial or secondary to an underlying bleeding disorder or a potentially serious systemic illness. Based on etiology, they can be categorized into disorders affecting platelets or the coagula...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-012-0918-2
更新日期：2013-05-01 00:00:00
abstract：:Intolerance to foods which contain lactose can cause a range of intestinal and systemic symptoms. These symptoms are caused by Lactase deficiency which is encoded by a single gene (LCT) of ≈ 50 kb located on chromosome 2q21. In some food items, lactose has been missed because of "hidden" lactose due to inadequately la...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-014-1346-2
更新日期：2014-09-01 00:00:00
abstract：OBJECTIVES:To evaluate if cardiac dysfunctions are important in assessing the outcome in newborns with Bronchopulmonary Dysplasia (BPD), by evaluating cardiac functions with N-terminal prohormone of brain natriüretic peptide (NT-proBNP) levels, M-mode and tissue doppler echocardiography at 6-12 mo of age. METHODS:Twen...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-013-0994-y
更新日期：2013-11-01 00:00:00
abstract：:The authors present 2 cases of dengue shock syndrome with unusual complications. In the first case, a 14-y-old boy with dengue shock syndrome who required aggressive fluid resuscitation, developed abdominal compartment syndrome (ACS). Patient developed severe shock, increased ventilator requirement and oliguria as a c...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-011-0551-5
更新日期：2012-03-01 00:00:00
abstract：:While Allergic bronchopulmonary aspergillosis (ABPA) is known to complicate asthma in adults, its association with childhood asthma is very rare. We present two patients, a four-and half year old boy who presented with severe asthma and a 12 year-old girl whose previous chest radiographs revealed fleeting opacities. B...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-009-0020-6
更新日期：2009-03-01 00:00:00
abstract：:The Asia Pacific Pediatric Association Vaccinology Update 2010 (APPA VU 2010) was held in Mumbai on November 13-14, 2010. This second part of the conference report discusses the interesting information about vaccines which are expected in the near future, namely, live-attenuated Japanese encephalitis virus vaccine, te...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-011-0385-1
更新日期：2011-08-01 00:00:00
abstract：:There is increased interest in the surgical management of epilepsy in children in the last decade or two. The plasticity of the developing brain and realization of the deleterious effects of uncontrolled seizures on the brain have prompted earlier surgery where indicated. All patients with uncontrolled partial seizure...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
abstract：:A two-and-a-half-year-old male child presented with recurrent attacks of intractable vomiting, psychomotor retardation since 14 months of age. He had also lower cranial nerve palsy and corticospinal involvement. Magnetic resonance imaging had shown multiple well circumscribed areas of hypointusity in T1 weighted image...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02730822
更新日期：1996-09-01 00:00:00
abstract：OBJECTIVE:To determine the utility of CSF Xpert MTB/RIF (GeneXpert) in diagnosis of tubercular meningitis in children in the age group of 2 mo to 12 y. METHODS:This hospital based prospective observational study was conducted at Department of Pediatrics, Karnataka Institute of Medical Sciences (KIMS), Hubli from Decem...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-019-03032-0
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the effects generated by an intensivist in pediatric intensive care unit (PICU) on the process of care and patient outcomes. METHODS:This study was a retrospective observational study conducted in the 16-bedded PICU of a tertiary referral center. Two years (2013-2015) period of the PICU without a...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-019-03154-5
更新日期：2020-04-01 00:00:00
abstract：OBJECTIVE:The purpose of the study is to report a unique association of clinical and pathological findings in a neonate. Foregut enteric duplication cysts--rare developmental anomalies that are associated with midline vertebral fusion anomalies. METHODS:We had a neonate with foregut duplication cyst who presented at b...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02726014
更新日期：2002-11-01 00:00:00
abstract：OBJECTIVE:To identify the causes and contributing factors of persistent pneumonia in children. METHODS:41 cases with persistent pneumonia were investigated (biochemical, microbiological, histopathological, immunological and radiological tests) to find out the underlying cause. RESULTS:Out of 41 cases, 8 had pulmonary...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-009-0272-1
更新日期：2009-12-01 00:00:00
abstract：:The reasons for comparatively low infant mortality rates in the Indian state of Kerala are examined. The importance of improvements in education and in the health care delivery system is stressed. ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02751009
更新日期：1985-09-01 00:00:00
abstract：OBJECTIVE:To assess the prevalence of peripheral neuropathy in HIV infected children (>5 y) receiving stavudine-based combination anti-retroviral treatment (ART) for more than 3 mo in a cross-sectional study. METHODS:History, detailed neurological examination and nerve conduction studies were performed. RESULTS:Forty...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-014-1477-5
更新日期：2015-02-01 00:00:00
abstract：:Early identification and treatment of children with autism and other developmental disorders is an international priority. Currently there is great interest in lowering the age of identification. Attention has been focused on public awareness campaigns and the regular use of developmental screening tests by health car...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-015-1894-0
更新日期：2017-01-01 00:00:00
abstract：:Laboratory investigations are an integral part of evaluation of a child with rheumatic disease. In rheumatic diseases markers of inflammation like CRP and erythrocyte sedimentation are usually raised. In addition, various autoantibodies like anti-nuclear antibody, rheumatoid factor, anti-neutrophil cytoplasmic antibod...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02723714
更新日期：2002-10-01 00:00:00
abstract：:High vaginal swabs (HVS) of 1792 expectant mothers were sent for culture at the time of delivery, prior to first vaginal examination. The newborns were followed-up for development of superficial or deep infections. Appropriate cultures of the babies who developed infections were sent. Bacterial growth of predominantly...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02820186
更新日期：1991-09-01 00:00:00
abstract：:The advent of AIDS has raised a concern regarding transfusion transmitted diseases. Blood transfusion is safer than ever before through continued improvements in safe donor recruitment, screening of donors, testing of donated blood and appropriate clinical use of blood. The risk of residual infections is further reduc...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02722029
更新日期：2001-02-01 00:00:00
abstract：OBJECTIVES:To analyse the clinical and molecular spectrum of Lipoprotein Lipase (LPL) deficiency and to highlight the effect of a cost-effective indigenous diet for management of this disorder. METHODS:This is a single-centre retrospective study. Fifteen patients from 14 kindreds with severe hypertriglyceridemia (more...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-020-03305-z
更新日期：2021-02-01 00:00:00
