Peripheral neuropathy in children on stauvudine therapy.

Abstract:

OBJECTIVE:To assess the prevalence of peripheral neuropathy in HIV infected children (>5 y) receiving stavudine-based combination anti-retroviral treatment (ART) for more than 3 mo in a cross-sectional study. METHODS:History, detailed neurological examination and nerve conduction studies were performed. RESULTS:Forty children [26 boys; median age - 11.75 y, Inter quartile range (IQR): 9-16 y] were enrolled. The median duration of ART was 43 mo [IQR: 18-69 mo]. The nerve conduction studies were abnormal in four children (10 %). Symptomatic distal sensory polyneuropathy was present in two children, asymptomatic distal sensory polyneuropathy and subclinical distal sensory polyneuropathy was present in one child each. CONCLUSIONS:Distal sensory polyneuropathy is a potential problem in children on stavudine based ART. Children on stavudine based ART need periodic clinical and electrophysiological screening for its early detection.

journal_name

Indian J Pediatr

authors

Sankhyan N,Lodha R,Sharma S,Menon PR,Choudhary A,Kabra SK,Gulati S

doi

10.1007/s12098-014-1477-5

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

136-9

issue

2

eissn

0019-5456

issn

0973-7693

journal_volume

82

pub_type

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