Abstract:
:Nephrotic syndrome in children is a common recurrent disease. Most of the cases are due to minimal change disease with a favourable outcome. More than 90% of children with minimal change disease respond to corticosteroid therapy (steroid sensitive nephrotic syndrome). 40-60% experience frequent relapses or have steroid dependence. These children require frequent corticosteroid therapy and/or immunomodulators or treatment with immunosuppressants, and are at high risk of cumulative steroid toxicity and side effects of cytotoxic therapy. Children with frequent relapses or steroid dependence should be managed in consultation with a pediatric nephrologist. Despite relapsing course, progression of minimal change nephrotic syndrome to end stage renal disease is extremely rare.
journal_name
Indian J Pediatrjournal_title
Indian journal of pediatricsauthors
Nanjundaswamy HM,Phadke KDdoi
10.1007/BF02724388keywords:
subject
Has Abstractpub_date
2002-12-01 00:00:00pages
1059-63issue
12eissn
0019-5456issn
0973-7693journal_volume
69pub_type
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