Abstract：
:Recently, new broad spectrum carbapenem has been investigated on a world-wide scale for the treatment of moderate to severe infections. In the neonatal intensive care units the extensive use of third generation cephalosporins for therapy of neonatal sepsis may lead to rapid emergence of multiresistant gram-negative organisms. We report the use of meropenem in 35 infants with severe infections due to Acinetobacter baumanii and Klebsiella pneumoniae. All gram negative bacteria were resistant to ampicillin, amoxicillin, ticarcilin, cefazoline, cefotaxime, ceftazidime, ceftriaxone and aminoglycosides. Eighty two percent of the cases (29/35) were born prematurely. Assisted ventilation was needed in 85.7% (30/35). All infants deteriorated during their conventional treatment and were changed to meropenem monotherapy. Six percent (2/35) died. The incidence of drug-related adverse events (mostly a slight increase in liver enzymes) was 8.5%. No adverse effects such as diarrhea, vomiting, rash, glossitis, oral or diaper area moniliasis, thrombocytosis, thrombocytopenia, eosinophilia and seizures were observed. At the end of therapy, overall satisfactory clinical and bacterial response was obtained in 33/35 (94.3%) of the newborns treated with meropenem. Clinical and bacterial response rates for meropenem were 100% for sepsis and 87.5% for nosocomial pneumonia. This report suggests that meropenem may be a useful antimicrobial agent in neonatal infections caused by multiresistant gram negative bacilli. Further studies are needed to confirm these results: Meropenem, newborn, sepsis and nosocomial infection.
journal_name
Indian J Pediatrjournal_title
Indian journal of pediatricsauthors
Köksal N,Hacimustafaoğlu M,Bağci S,Celebi Sdoi
10.1007/BF02728850keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
15-9issue
1eissn
0019-5456issn
0973-7693journal_volume
68pub_type
临床试验,杂志文章abstract：:Forty children aged 5 months to 3 years and suffering from wheezy baby syndrome (WBS) were evaluated to find out the prevalence of neonatal meconium aspiration syndrome (MAS) from the birth records. Twelve (30%) babies with WBS were detected to have a history of MAS at birth, significant enough to require a neonatal I...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02750935
更新日期：1991-07-01 00:00:00
abstract：OBJECTIVE:To present evaluation of a quality improvement program for Accredited Social Health Activists (ASHAs). METHODS:This community intervention trial was conducted in Ballabgarh, India during 2012-2014 with two Primary Health Center (PHC) areas being the intervention areas and two PHC areas being non-intervention...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-019-03012-4
更新日期：2019-11-01 00:00:00
abstract：:Type 1 diabetes mellitus is considered a common form of diabetes mellitus in young people. Type 1 diabetes in infants is rare. However, the condition is rare in infants. Type 1 diabetes has not been reported in the literature in 45 days old child of an Indian population. Type 1 diabetes typically begins between the ag...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-009-0009-1
更新日期：2009-04-01 00:00:00
abstract：:The renal tubule plays an important role in fluid and electrolyte homeostasis. Renal tubular disorders may affect multiple ( e.g., Fanconi syndrome) or specific (e.g., nephrogenic diabetes insipidus, renal glucosuria) tubular functions. Most conditions are primary and monogenic but occasionally are secondary to other ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02734150
更新日期：2005-09-01 00:00:00
abstract：:Developmental co-ordination disorder (DCD) is a hidden complex childhood disorder seen in school aged children. There are only few Indian literatures supporting the prevalence of DCD among Indian school children but this current research has attempted to make a confirmatory diagnosis of DCD. Objective of the study was...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-020-03191-5
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVES:To evaluate the efficacy and safety of nitazoxanide in intestinal parasitic infections in children. METHODS:Four databases, PubMed, EMBASE, Web of Science and Cochrane Library, have been systematically searched from the inception of each database up to March 1st, 2019. The enrolled studies were limited to r...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,meta分析
doi：10.1007/s12098-019-03098-w
更新日期：2020-01-01 00:00:00
abstract：:This case describes a contiguous mediastinal and retroperitoneal mature teratoma in a congenital diaphragmatic defect, a combination that is hitherto unreported in literature. It substantiates embryological chronology of events during the cephalad migration of the primordial germ cells through the developing diaphragm...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-010-0020-6
更新日期：2010-05-01 00:00:00
abstract：:Septic arthritis in children remains a serious disease with the potential for significant systemic and musculoskeletal morbidity. Staphlococcus aureus is the most common cause of bone and joint infections in all age groups. Microbial invasion of the synovial space occurs typically results from hematogenous seeding. Di...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02730722
更新日期：2004-09-01 00:00:00
abstract：:Bone injuries during the process of delivery were studied among 34, 946 live born babies over a 11 period. There were 35 cases of bone injuries giving an incidence of 1 per 1,000 live births. Clavicle was the commonest bone fractured (45.7%) followed by humerus (20%), femur (14.3%) and depressed skull fracture (11.4%)...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02751901
更新日期：1994-07-01 00:00:00
abstract：:A 4 year-old girl had coxa vara, tibial bowing and hyperpigmented macules. The x-ray showed polyostotic fibrous dysplasia and evidence of rickets. Biochemical investigations confirmed hyperphosphaturic hypophosphatemic rickets. The literature has been reviewed. ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02727183
更新日期：1999-07-01 00:00:00
abstract：:Rotary one of the largest non-government international organization focused mainly towards the up-liftment of the downtrodden worldwide, got involved in the Polio Eradication Program way back in 1979 with a five-year pledge to immunize about six million Philippine children from the crippling disease of poliomyelitis. ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02722705
更新日期：2002-08-01 00:00:00
abstract：:A detailed information on a total of 448 consecutive Nepali births which occurred between January 1, 1985 and December 31, 1994 was collected from the birth registers of the Khasi-Jaintia Presbetyrian Synod Hospital of Shillong, Meghalaya. After the exclusion of still and twin births, and the cases of missing informat...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02760471
更新日期：2000-07-01 00:00:00
abstract：OBJECTIVES:To investigate the presence of Y-chromosome sequences and determine their frequency in patients with Turner syndrome. METHODS:The study included 23 patients with Turner syndrome from Brazil, who gave written informed consent for participating in the study. Cytogenetic analyses were performed in peripheral b...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-015-1929-6
更新日期：2016-05-01 00:00:00
abstract：OBJECTIVE:To evaluate all steps of pulse polio immunization on special sub national immunization day. METHODS:On a sub-national immunization day (SNID), 120 booths were randomly selected from 662 booths by probability proportionate to size (PPS) sampling technique. RESULTS:It was observed that attendance in the distr...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-009-0025-1
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the presentation, treatment and outcome of testicular tumors in undescended testes (UDT) in boys below 5 y of age. METHODS:Case records of boys below 5 y of age, diagnosed to have germ cell tumors (GCT) in the UDT were reviewed. RESULTS:Seven children in the age range of 05-54 mo (mean 26 mo) we...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-014-1667-1
更新日期：2015-06-01 00:00:00
abstract：:Effective communication with parents is a very important skill for pediatricians especially in a neonatal setup. The authors analyzed non-verbal communication of medical caregivers during counseling sessions. Recorded videos of counseling sessions from the months of March-April 2016 were audited. Counseling episodes w...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-018-2680-6
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVE:Heterosexual contact is the predominant mode of transmission among adults in India with an increasing number of women of childbearing age becoming infected with HIV. Consequently, children in India increasingly getting infected, primarily from vertical transmission. A retrospective review of the profile of HI...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02724249
更新日期：2003-08-01 00:00:00
abstract：OBJECTIVE:Of this pilot study was to assess the iron status and dietary intake of 1-3 year-old apparently healthy toddlers of the lower socio-economic class, and the effect of eight weeks intervention with liquid oral iron in an urban slum in Pune, India. METHODS:50 toddlers (M= 25, F= 25) with mean age of 2.4 years (...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-008-0038-1
更新日期：2008-04-01 00:00:00
abstract：:Computers can help to liberate students from the burden of rote learning of facts and enhance the role of reason and imagination in the learning process. Arguably, the computers constitute the most important single resource ever to become available to the teachers and students since the invention of the printing press...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02843603
更新日期：1994-03-01 00:00:00
abstract：OBJECTIVE:To evaluate the antenatal profile of the mother and the immediate neonatal morbidity and mortality till discharge. METHODS:The study was a retrospective analysis of 92 patients of preterm labour who delivered babies weighing RESULTS:A total of 92 mothers in preterm labour at 26 to 34 weeks were admitted and...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02898441
更新日期：2006-08-01 00:00:00
abstract：:Approximately 25,000 children develop multidrug-resistant (MDR) tuberculosis (TB) each year, but few of them are diagnosed and appropriately treated for MDR-TB. New diagnostic tools have improved our ability to diagnose children with bacteriologically confirmed TB earlier. However, the majority of childhood TB cases a...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-018-02846-8
更新日期：2019-08-01 00:00:00
abstract：:There are 10 steps to consider in any research study. These steps can be used to perform a critical appraisal of a published paper, or to design your study in the first place. The use of a simple system such as this can ensure that biases in study design are avoided and that an appropriate study is developed. (1) What...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02802638
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVE:To identify the risk factors for small for gestational age (SGA) babies. METHODS:The present study was a nested case control study which was carried out by two Medical Officers of Health areas (The field level administrative unit responsible for provision of preventive and promotive health services) in Colom...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-014-1382-y
更新日期：2014-10-01 00:00:00
abstract：:Systemic infection in the newborn is the commonest cause of neonatal mortality. Data from National Neonatal Perinatal Database 2000 suggest that Klebsiella pneumoniae and Staphylococcus aureus are the commonest causes of neonatal sepsis in India. Two forms of clinical presentations have been identified. Early onset se...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02722932
更新日期：2001-12-01 00:00:00
abstract：:Epilepsy is a common childhood neurological morbidity needs careful evaluation, relevant investigations and precise therapy with appropriate antiepileptic drugs for optimal duration. Majority of childhood epilepsy remits with antiepileptic drugs and should be managed in the community. Practising pediatricians must cou...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02723743
更新日期：2003-02-01 00:00:00
abstract：:In neonatal period anemia is a complex problem owing to the unique blood picture. The erythrocytic system undergoes serial adaptation to meet progressively changing demands of oxygen in the embryo, the fetus and neonate. This leads to rapid change in normal hematological change in post-birth period. Definition of anem...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02730596
更新日期：2003-11-01 00:00:00
abstract：:Chronic Epididymitis is a relatively rare problem in boys and is often enigmatic in its etiology. It is often associated with urinary tract abnormalities in infants and prepubertal children. This report describes a rare and unusual case of a chronic epididymitis with acquired scrotal vasocutaneous urinary fistula in a...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-012-0740-x
更新日期：2013-05-01 00:00:00
abstract：:Adrenal hemorrhage has many etiologies including bleeding diathesis. A 10-day-old female baby was admitted to our clinic with the complaint of abdominal distention. Hemorrhage was determined on the right adrenal gland with abdominal ultrasonography and computerized tomography. Laboratory investigations showed PT 44 se...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02723786
更新日期：2002-01-01 00:00:00
abstract：:Allgrove syndrome consists of triad of Adrenal hypoplasia, Achalasia cardia and Alacrimia. Often the first manifestation of adrenal hypoplasia is Addisonian crisis precipitated by infection or trauma. We present case of a 9-year-old boy who presented in shock due to adrenal failure later confirmed to have Allgove synd...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-007-0179-7
更新日期：2007-10-01 00:00:00
abstract：:Developmental disabilities (DD) are defined as a diverse group of severe chronic conditions due to mental and/or physical impairments. Individuals with developmental disabilities have difficulty with major life activities including language, mobility, and learning. Developmental disabilities can begin anytime during d...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02731671
更新日期：2005-11-01 00:00:00
