Megaloblastic anemia: back in focus.

Abstract:

:Megaloblastic anemia (MA), in most instances in developing countries, results from deficiency of vitamin B(12) or folic acid. Over the last two to three decades, incidence of MA seems to be increasing. Of the two micronutrients, folic acid deficiency contributed to MA in a large majority of cases. Now deficiency of B(12) is far more common. In addition to anemia, occurrence of neutropenia and/or thrombocytopenia is increasingly being reported. Among cases presenting with pancytopenia, MA stands out as an important (commonest cause in some series) cause. This article focuses on these and certain other aspects of MA. Possible causes of increasing incidence of MA are discussed. Observations on other clinical features like neurocognitive dysfunction, associated hyperhomocysteinemeia and occurrence of tremors and thrombocytosis during treatment are highlighted.

journal_name

Indian J Pediatr

authors

Chandra J

doi

10.1007/s12098-010-0121-2

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

795-9

issue

7

eissn

0019-5456

issn

0973-7693

journal_volume

77

pub_type

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