Abstract：
:Approximately 25,000 children develop multidrug-resistant (MDR) tuberculosis (TB) each year, but few of them are diagnosed and appropriately treated for MDR-TB. New diagnostic tools have improved our ability to diagnose children with bacteriologically confirmed TB earlier. However, the majority of childhood TB cases are not bacteriologically confirmed; therefore a high index of suspicion is needed, and taking a detailed history of contact with drug-resistant source cases and previous TB treatment is important to identify presumed MDR-TB cases. Treatment for MDR-TB is rapidly changing with the addition of new and repurposed drugs, the introduction of shorter regimens and the move towards injectable-free, all-oral MDR-TB treatment regimens. Children have been neglected in the introduction of the new drugs, but drug dosing and safety studies are now being completed. This article presents a practical approach in deciding which regimen to use in individual children in need of MDR-TB treatment. Outcomes in those treated are generally good, but only <5% of children with MDR-TB are currently diagnosed and appropriately treated. Diagnosing children with MDR-TB and getting them on to correct treatment regimens should now be our main focus.
journal_name
Indian J Pediatrjournal_title
Indian journal of pediatricsauthors
Schaaf HSdoi
10.1007/s12098-018-02846-8subject
Has Abstractpub_date
2019-08-01 00:00:00pages
717-724issue
8eissn
0019-5456issn
0973-7693pii
10.1007/s12098-018-02846-8journal_volume
86pub_type
杂志文章,评审abstract：:Intolerance to foods which contain lactose can cause a range of intestinal and systemic symptoms. These symptoms are caused by Lactase deficiency which is encoded by a single gene (LCT) of ≈ 50 kb located on chromosome 2q21. In some food items, lactose has been missed because of "hidden" lactose due to inadequately la...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-014-1346-2
更新日期：2014-09-01 00:00:00
abstract：:In India, child malnutrition is prevalent, especially among the poor and vulnerable. It is mostly the result of high levels of exposure to infection and inappropriate infant and young child feeding and caring practices, and it sets in mostly during the first 2 to 3y of life. Therefore, the present study was done to as...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-012-0894-6
更新日期：2013-12-01 00:00:00
abstract：:Early identification and treatment of children with autism and other developmental disorders is an international priority. Currently there is great interest in lowering the age of identification. Attention has been focused on public awareness campaigns and the regular use of developmental screening tests by health car...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-015-1894-0
更新日期：2017-01-01 00:00:00
abstract：: ...
journal_title：Indian journal of pediatrics
pub_type： 信件
doi：10.1007/s12098-018-2771-4
更新日期：2019-02-01 00:00:00
abstract：:A cross-sectional study was conducted on the children of 146 randomly selected families in Abha, Saudi Arabia. Counting of teeth and examination for caries teeth of children under 12 years of age were done by family visits. The results showed that no child developed teeth before 5 months. By 12 months there were on an...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02722141
更新日期：1990-01-01 00:00:00
abstract：OBJECTIVE:Despite the need to have adolescent-centric policies and mental health services, India is yet far from having one. The authors aimed at generating opinions on the need to have adolescent focused policies and clinical services using the data on Anxiety Disorders they collected from the community. METHODS:This...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-013-1227-0
更新日期：2013-11-01 00:00:00
abstract：:Tuberous sclerosis complex (TSC) is an autosomal dominant disorder, caused due to mutations in the TSC1 and TSC2 genes. Mutations in TSC2 gene are more common than in TSC1 gene and mostly they are in the form of large genomic deletions or duplications. The authors report on a novel deletion in TSC2 gene, prenatal diag...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-011-0408-y
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:To find the prevalence of associated anomalies in children with anorectal malformation (ARM). METHODS:One hundred and forty patients (80 males and 60 females) with expand were studied to detect associated anomalies and to find their prevalence. High and low type of ARM was seen in 52.14% and 47.86% of patien...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02724292
更新日期：2004-06-01 00:00:00
abstract：:Effective management of tuberculosis (TB) in children and important data of disease burden continue to rely on a clinical approach to diagnosis, as diagnosis of childhood TB is not confirmed in the majority. Many diagnostic scoring systems have been developed to aid with diagnosis. This article reviews the use and eva...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-010-0307-7
更新日期：2011-03-01 00:00:00
abstract：:Two hundred and three multi-transfused children with thalassemia attending the thalassemia clinic of the Charak Palika Hospital, New Delhi were screened for human immuno-deficiency virus (HIV) antibodies by ELISA test. All positive cases were confirmed by the Western blot test. Of the 203 children screened, 17 (8.37%)...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02751556
更新日期：1992-07-01 00:00:00
abstract：:Cryptosporidium is an intestinal protozoa known to cause diarrhea in animals and more recently has been recognised as a cause of diarrhea in humans. The present study was designed to determine the prevalence of cryptosporidium as a cause of diarrhea in children. Faecal samples of 180 children admitted to the hospital ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02749728
更新日期：1989-01-01 00:00:00
abstract：:Tetanus is still an important cause of morbidity and mortality in developing countries. Fifty two patients with tetanus were admitted within a 15 year period to our hospital, and 24 of them died. The remaining cases were called for re-evaluation 3-13 years after the infection. Only 10 cases were admitted again, and 6 ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02752221
更新日期：1994-05-01 00:00:00
abstract：:An 11-mo-old infant received 12.5 times the maximum therapeutic dose of amlodipine as a result of a medication error in lieu of amoxicillin. He presented with vomiting, lethargy, breathlessness, muffled heart sounds and progressed to hypotensive shock within three hours of admission. He received mechanical ventilation...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-012-0861-2
更新日期：2013-06-01 00:00:00
abstract：:Secondary sex characteristics were evaluated in thalassemic children (41, boys and 30 girls), who were on regular transfusion therapy and were above 11 years of age. The results of this study indicate that the development of secondary sex characteristics in thalassemic children is markedly delayed as compared to their...
journal_title：Indian journal of pediatrics
pub_type： 临床试验,杂志文章
doi：10.1007/BF02725511
更新日期：1997-11-01 00:00:00
abstract：OBJECTIVE:To predict neuromotor outcome in Very Low Birth Weight infants at 1 year using Movement Assessment of Infants scale at 4 and 8 months of corrected age. METHODS:This hospital based prospective observational study consecutively recruited 45 infants with birth weight ≤ 1,500 g and admitted to neonatal intensive...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-011-0468-z
更新日期：2011-11-01 00:00:00
abstract：:In the pediatric patient, computed tomography (CT) scan as an imaging modality for evaluation of the abdomen is to be used judiciously. The use of correct scanning protocols, single phase scanning, scanning only when required are key factors to minimize radiation doses to the child, while providing diagnostic quality....
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-016-2030-5
更新日期：2016-07-01 00:00:00
abstract：OBJECTIVES:To analyse the clinical and molecular spectrum of Lipoprotein Lipase (LPL) deficiency and to highlight the effect of a cost-effective indigenous diet for management of this disorder. METHODS:This is a single-centre retrospective study. Fifteen patients from 14 kindreds with severe hypertriglyceridemia (more...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-020-03305-z
更新日期：2021-02-01 00:00:00
abstract：OBJECTIVE:Jaundice is a common clinical problem in neonatal period which may result in brain damage even in healthy full term newborns, when it is severe. The aim of this study was to characterize the therapeutic effect of clofibrate in full term neonates who present with nonhemolytic jaundice. METHODS:A clinical cont...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12098-007-0184-x
更新日期：2007-11-01 00:00:00
abstract：:Genetic counseling is a process of communicating medical aspects about a genetic disorder, especially the information regarding risk of occurrence as recurrence of the disease in the family and preventive options. Accurate diagnosis of the affected member is of paramount importance for genetic counseling. Special gene...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02723098
更新日期：2004-02-01 00:00:00
abstract：:The OMENS syndrome involves craniofacial maldevelopment of the orbit, ear cranial nerve and soft tissue, while OMENS-plus syndrome also includes extracraniofacial anomalies. These may be skeletal, cardiovascular, gastrointestinal, pulmonary, renal and central nervous system malformations. A fourteen-year-old girl pres...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02724084
更新日期：2005-08-01 00:00:00
abstract：OBJECTIVE:To estimate the prevalence of culture-confirmed cholera in patients with acute dehydrating diarrhea, at a tertiary care center in north India, during a 6-month period from March to August, 2006. METHODS:We studied 145 children, who presented to the pediatric emergency services of a tertiary care teaching hos...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-010-0009-1
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVES:To screen patients with frequently relapsing nephrotic syndrome (FRNS) for the presence of ambulatory hypertension and left ventricular hypertrophy. METHODS:Following ethical and parental approvals, consecutive patients with FRNS of ≥2 y duration were enrolled. Those with estimated glomerular filtration rat...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-016-2207-y
更新日期：2017-01-01 00:00:00
abstract：:India recognized the importance of improving the health and nutritional status of children, and initiated steps to improve access to nutrition and health services soon after independence. Over the years, the infrastructure and human resources for manning the health and nutrition services have been built up and current...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-010-0038-9
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVE:To assess the benefits of nutrition supplementation in children living with HIV (CLHIV). METHODS:A prospective observational study was carried out at antiretroviral therapy (ART)/pediatric centre of excellence (PCOE), Niloufer hospital for a period of one year in CLHIV (N = 164) aged 1 to 18 y referred to AR...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-015-1873-5
更新日期：2016-03-01 00:00:00
abstract：:Eighty-seven patients with pectus excavatum underwent cardiac examination and echocardiography (M-mode) to determine the diagnostic significance of pectus in children for mitral valve prolapse (MVP). Patients' ages ranged from 1 month to 18 years with a mean age of 5.4 years. Sixty-seven were males. Twenty of the 87 p...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02722092
更新日期：1990-03-01 00:00:00
abstract：OBJECTIVE:To determine the utility of CSF Xpert MTB/RIF (GeneXpert) in diagnosis of tubercular meningitis in children in the age group of 2 mo to 12 y. METHODS:This hospital based prospective observational study was conducted at Department of Pediatrics, Karnataka Institute of Medical Sciences (KIMS), Hubli from Decem...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-019-03032-0
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVE:To compare the insertion characteristics, utilization profile, life span and the complication rates of Central lines (CL) and Peripherally inserted central lines (PICL). METHODS:A prospective study of all CL or PICL insertions during January 2007 to September 2007 in the Neonatal Surgical Intensive Care Unit...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-009-0291-y
更新日期：2010-02-01 00:00:00
abstract：OBJECTIVE:To understand the causes of child deaths in order to implement appropriate child survival interventions in the country. We present a systematic review of studies reporting causes of child, infant, and neonatal deaths from India for 1985 to 2008. METHODS:PubMed, EMBASE, Google Scholar, and WHO regional databa...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-010-0246-3
更新日期：2010-11-01 00:00:00
abstract：:Auditory evoked responses using BERA were studied in 30 newborn babies with plasma bilirubin > or = 15 mgm/dl and repeated after treatment of neonatal jaundice with bilirubin levels of < or = 10 mgm/dl. A few jaundiced babies (16.5%) showed absent BERA response at the initial/subsequent examination. After treatment, 3...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02751203
更新日期：1993-05-01 00:00:00
abstract：:Conducting economic evaluation alongside clinical trials is an efficient way of getting valid and reliable information with minimum assumptions made during data collection. However, design of a randomised control trial (RCT) takes away several of the real world situations, the variations in resource utilisation, their...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02820689
更新日期：2000-05-01 00:00:00
