Pulmonary Function Tests in Sickle Cell Disease.

Abstract:

OBJECTIVE:To determine pulmonary function abnormalities in children with Sickle Cell Disease (SCD) from Western India. METHODS:In this cross sectional study conducted at Surat, Gujarat, India; equal number of age and gender matched children i.e., 99 in the age group of 6-18 y was recruited in case (children with SCD) and control (non-SCD healthy children) groups respectively. Weight, height, body mass index (BMI) and hemoglobin (Hb) were assessed as baseline characteristics and spirometry was performed to assess the pulmonary function. RESULTS:The two groups of children were comparable in the baseline characteristics such as weight, height and BMI, however mean hemoglobin was significantly low in SCD as compared to healthy controls [9.1 ± 1.52 vs. 11.4 ± 1.04 (p=0.001)]. Mean (% predicted) Forced expiratory volume in 1 s (FEV1) (86.79 ± 11.6 vs. 94.3 ± 16.1) and FVC (84.4 ± 11.5 vs. 91.75 ± 15.2) values were significantly low (p < 0.001) in cases. CONCLUSIONS:The present study revealed that the difference of pulmonary function tests between sickle cell patients and normal age matched controls were statistically significant but this difference was not clinically significant.

journal_name

Indian J Pediatr

authors

Purohit R,Rao SS,Goyal JP,Shah VB,Charan J

doi

10.1007/s12098-016-2065-7

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

783-6

issue

8

eissn

0019-5456

issn

0973-7693

pii

10.1007/s12098-016-2065-7

journal_volume

83

pub_type

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