Abstract:
:Tumor lysis syndrome (TLS) refers to the constellation of deranged metabolic state, characterized by hyperkalemia, hyperphosphatemia, hyperuricemia, hypocalcemia, and/or azotemia, secondary to rapid breakdown of tumor cells. It is a life threatening emergency that typically follows administration of chemotherapy or may be spontaneous. Malignancies which have a large tumor burden, rapid turnover, as well as speedy breakdown following chemotherapy are susceptible. Acute lymphoblastic leukemia and non-Hodgkins lymphoma (particularly Burkitt's lymphoma) are typically predisposed. TLS is best managed by early anticipation and preventive measures than the complicated task of treating an established TLS. Vigorous intravenous hydration is the cornerstone of prevention as well as treatment. Rasburicase has revolutionized the management. It is available in India for past 1 1/2 y, although the cost is a limiting factor. Children with acute leukemia in developing countries may reach health facility late, with severe anemia and hyperleukocytosis. Exchange transfusion may have to be restored to in such patients to simultaneously correct anemia and hyperleukocytosis and enable safe administration of fluids. Dialysis may be required when the metabolic 'trash' overwhelms the renal excretion, resulting in renal failure. Chemotherapeutic drugs are often administered in a phased manner in susceptible patients, in an attempt to prevent precipitous lysis of tumor cells. Presentation and management of TLS in relevance to the pediatric emergency room is outlined.
journal_name
Indian J Pediatrjournal_title
Indian journal of pediatricsauthors
Rajendran A,Bansal D,Marwaha RK,Singhi SCdoi
10.1007/s12098-012-0824-7subject
Has Abstractpub_date
2013-01-01 00:00:00pages
50-4issue
1eissn
0019-5456issn
0973-7693journal_volume
80pub_type
杂志文章abstract::Although Kawasaki disease (KD) is now being increasingly reported from India, the vast majority of children with KD are still not being diagnosed and treated. A recent study from Chandigarh has shown that the incidence of KD is at least 4.54/100,000 children below 15 y of age. Extrapolations of this figure suggest tha...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-013-1229-y
更新日期:2014-04-01 00:00:00
abstract::Frank-Ter Haar syndrome is an unusual type of skeletal dysplasia with megalocornea and developmental delay. It is usually transmitted as autosomal recessive disorder. Only a few cases have been reported in the literature and none from India. The authors report a case with other unusual features and a short review of t...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-011-0599-2
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVES:To generate consensus on the assessment of hypotonia in the pediatric population, more specifically with respect to the clinical characteristics and first line tests and methods to be used to assess these characteristics. METHODS:Consensus methodology was used. A sample of experts was recruited based on spe...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-013-1018-7
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:To document the immunization rates, factors associated with incomplete immunization, and missed opportunities for immunizations in children affected by HIV presenting for routine outpatient follow-up. METHODS:A cross-sectional study of immunization status of children affected by HIV presenting for routine ou...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-013-1049-0
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:To prospectively study the clinical and developmental profile; hematological profile and the B-12 status using multiple parameters in children with Infantile tremor syndrome (ITS). METHODS:In this observational study (NCT02762682) (July 2015 through December 2016) children (and their mothers) with a clinica...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-019-03117-w
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:To analyse the clinical and molecular spectrum of Lipoprotein Lipase (LPL) deficiency and to highlight the effect of a cost-effective indigenous diet for management of this disorder. METHODS:This is a single-centre retrospective study. Fifteen patients from 14 kindreds with severe hypertriglyceridemia (more...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-020-03305-z
更新日期:2021-02-01 00:00:00
abstract::Paraphenylene daimine (PPD) is a kind of aromatic amine that is widely used in several industrial products. Women also use PPD added to henna (Lawasonia alba) as a hair dye. Though rare in Western countries, PPD poisoning is quite common in East Africa, India and Middle Eastern countries because it is a traditional pr...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-013-1074-z
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To assess Ankle-Foot-Orthosis (AFO) requirement and ambulation in Duchenne Muscular Dystrophy (DMD) patients seen over a period of 4 y at a multi-disciplinary Neuromuscular disorders clinic (NMD). METHODS:A study was conducted in university quaternary research hospital with DMD patients confirmed by MLPA (mu...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-016-2251-7
更新日期:2017-03-01 00:00:00
abstract::Lead poisoning is a preventable entity that can affect almost every system of the body. Its toxic effects range from subtle common childhood symptoms to even death. In a prospective study forty six children with at least one symptom compatible with plumbism were enrolled after screening patients attending medical serv...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02726170
更新日期:2000-02-01 00:00:00
abstract::Bronchopulmonary dysplasia (BPD) is a chronic lung disease associated with premature birth and characterized by early lung injury. Over the past 4 decades, there have been significant changes in its definition, pathology and radiological findings as well as management of BPD. Management of the acute phase and later st...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-007-0032-z
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:This study was carried out to evaluate the adequacy of seroconversion when Hepatitis B vaccine is given along with other vaccines at 0, 6 weeks (along with DPT and OPV) and at 9 months (along with measles). METHODS:725 infants born to apparently healthy mothers were enrolled to receive the hepatitis B vaccin...
journal_title:Indian journal of pediatrics
pub_type: 临床试验,杂志文章
doi:10.1007/BF02724073
更新日期:2005-08-01 00:00:00
abstract::High dose vitamin A (HDVA) concentrate began to be distributed in India in 1970 as a short-term, stop-gap approach to reduce clinical signs of vitamin A deficiency. As this problem declined globally, the purpose of distributing them changed to the reduction of young child mortality. However, their impact on this has a...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-018-02851-x
更新日期:2019-06-01 00:00:00
abstract::Pediatricians and family practitioners have the responsibility of providing the crucial primary care for the children. They are considered to be in a unique position to contribute to the dental health of their young patients. In view of this a study was conducted in Mangalore city (India) to assess pediatricians' view...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02759903
更新日期:2006-06-01 00:00:00
abstract::Ocular manifestations that occur directly or indirectly as result of a pathologic process that involves other parts of the body, in a pediatric population, will be discussed here. While a myriad number of systemic conditions have ocular manifestations, its importance cannot be undermined because it has implications fo...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-018-2623-2
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:To screen for variants in the MC4R and LEP genes in 46 patients with clinical suspicion of non-syndromic early onset severe obesity (NEOSO). METHODS:Children with early onset obesity satisfying WHO criteria of obesity were studied. The MC4R and LEP genes were sequenced using a PCR amplicon based NGS on Illu...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-019-03129-6
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:Of this pilot study was to assess the iron status and dietary intake of 1-3 year-old apparently healthy toddlers of the lower socio-economic class, and the effect of eight weeks intervention with liquid oral iron in an urban slum in Pune, India. METHODS:50 toddlers (M= 25, F= 25) with mean age of 2.4 years (...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-008-0038-1
更新日期:2008-04-01 00:00:00
abstract::Untreated vertically transmitted human immunodeficiency virus (HIV) infection progresses rapidly with 50% mortality at 1 y and most of the remainder dying before 5 y of age. The authors present a case of a 13-y-old boy, a paternal orphan with vertically transmitted HIV infection, lost to follow up after diagnosis in i...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-011-0670-z
更新日期:2012-09-01 00:00:00
abstract::A bleeding child is a cause of great concern and often, panic, for parents and pediatricians alike. Causes of bleeding could be trivial or secondary to an underlying bleeding disorder or a potentially serious systemic illness. Based on etiology, they can be categorized into disorders affecting platelets or the coagula...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-012-0918-2
更新日期:2013-05-01 00:00:00
abstract::Hypothyroidism and type 1 diabetes mellitus (T1DM) constitute two common endocrine disorders of children. Both these are chronic conditions which require long term follow-up for optimum control, can be missed on initial presentation unless a high index of suspicion is maintained and may be associated with adverse outc...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-013-1101-0
更新日期:2013-08-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:2000-03-01 00:00:00
abstract::India recognized the importance of improving the health and nutritional status of children, and initiated steps to improve access to nutrition and health services soon after independence. Over the years, the infrastructure and human resources for manning the health and nutrition services have been built up and current...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-010-0038-9
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects generated by an intensivist in pediatric intensive care unit (PICU) on the process of care and patient outcomes. METHODS:This study was a retrospective observational study conducted in the 16-bedded PICU of a tertiary referral center. Two years (2013-2015) period of the PICU without a...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-019-03154-5
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVES:In India, girls are sex-selectively abandoned. The abandoned babies are brought to the nearest hospital under the jurisdiction of the administration. The authors aimed to study the demographic data and disease profile of those babies. METHODS:In this hospital-based, retrospective, descriptive study, authors...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-018-2838-2
更新日期:2019-04-01 00:00:00
abstract::The study was conducted to assess copper and zinc levels in neonate's serum, mother's serum, neonate's hair and urine and to ascertain association between them. It is of concern whether zinc and copper deficiency is present at birth and maternal blood and breast milk zinc and copper levels have any effect on this. The...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02726255
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVE:To review contemporary guidelines and therapies for pediatric cardiac arrest and discuss potential novel therapies. METHODS:Key articles and guidelines in the field were reviewed along with recent publications in the fields of neurointensive care and neuroscience germane to cerebral resuscitation. RESULTS:A...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-008-0117-3
更新日期:2008-06-01 00:00:00
abstract::Antimicrobial resistance is a key factor leading to emerging/ re-emerging infections. Rational antimicrobial therapy or antimicrobial stewardship is one of the important interventions to prevent emergence of resistance. Choosing correct empiric therapy is crucial not only to prevent antimicrobial resistance but also t...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-019-03144-7
更新日期:2020-11-01 00:00:00
abstract::Incidence of allergic disorders in children has increased significantly over time due to environmental and life-style changes. These include allergic rhinitis, atopic dermatitis, allergic conjunctivitis, food allergies, bronchial asthma, drug allergies, insect bites and anaphylaxis; most being IgE-mediated type 1 hype...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-017-2436-8
更新日期:2018-01-01 00:00:00
abstract::Systemic infection in the newborn is the commonest cause of neonatal mortality. Data from National Neonatal Perinatal Database 2000 suggest that Klebsiella pneumoniae and Staphylococcus aureus are the commonest causes of neonatal sepsis in India. Two forms of clinical presentations have been identified. Early onset se...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF02722932
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVE:To study the iron profile and find out an accurate diagnostic tool which reflects iron status in different types of infection in severely malnourished children aged 12 months to 71 months. METHODS:Hundred and Eight (108) children of whom 72 children were infected and 36 non infected severely malnourished chi...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-009-0098-x
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:To assess the benefits of nutrition supplementation in children living with HIV (CLHIV). METHODS:A prospective observational study was carried out at antiretroviral therapy (ART)/pediatric centre of excellence (PCOE), Niloufer hospital for a period of one year in CLHIV (N = 164) aged 1 to 18 y referred to AR...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-015-1873-5
更新日期:2016-03-01 00:00:00