Abstract:
OBJECTIVE:To assess the treatment and outcome of children with acute myeloid leukemia. The Primary objectives were to assess remission rates, treatment related toxicity and disease free survival. Secondary objective was to assess prognostic factors associated with poor outcome. METHODS:A retrospective analysis of all treated patients with acute myeloid leukemia, less than 18 year of age from Sept 2005 to Aug 2009 was done. Clinical laboratory, treatment and follow up records retrieved to calculate remission rate, treatment related toxicity, disease free survival and poor prognostic factors. RESULTS:This analysis included thirty five patients (male : female; 23:12), twenty seven (77.1%) achieved remission after one 3 + 7 induction and seven required two inductions. High dose cytosine arabinoside consolidation was given in thirty one patients while one underwent allogenic stem cell transplantation. Two patients died during chemotherapy (TRM- 5.7%), two did not complete the therapy, seventeen relapsed (48.5%) with 80% of relapses occurring within first year of remission and no relapse occurred after 2 years. Fourteen patients are in remission (40%, follow up 5-54 months) and cumulative median disease free survival is of 13 months. CONCLUSIONS:The present data suggests that 3 + 7 induction, followed by high dose cytarabine consolidation has low treatment related toxicity and resource utilization; however, relapse free survival is inferior to more intensive regimens, highlighting the need to intensify chemotherapy regimen once the treatment related mortality has been minimized.
journal_name
Indian J Pediatrjournal_title
Indian journal of pediatricsauthors
Gupta N,Seth T,Mishra P,Mahapatra M,Rathi S,Kapoor R,Agarwal N,Kumar S,Saxena Rdoi
10.1007/s12098-010-0300-1subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1211-5issue
10eissn
0019-5456issn
0973-7693journal_volume
78pub_type
杂志文章abstract::A 29 day old male infant presented with a history of fever, cough, increasing respiratory distress and abdominal distension from the 10th day of life. Examination revealed failure to thrive, marked tachypnea, pallor, hepatosplenomegaly and harsh vesicular breath sounds. Chest skiagram showed extensive broncho-pneumoni...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02752376
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abstract::Data from 31 children, 23 females (74.2%) and eight males (25.8%) with precocious puberty were analysed. They included 19 cases with central precocious puberty, 5 with premature thelarche, 5 with premature adrenarche and 1 each with adrenal adenoma and virilizing hepatoblastoma. Their clinical and hormonal profile and...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02727928
更新日期:1990-05-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-014-1521-5
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:To determine the safety and efficacy of off label usage of Recombinant activated factor VII (rFVIIa) in children with severe bleeding in non-hemophiliac children with diverse etiologies like leukemia, post hematopoietic stem cell transplantation, dengue shock syndrome and Glanzmann thrombasthenia. METHOD:Med...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-011-0364-6
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:To describe the characteristics of Lophomonas blattarum infection in children based on a retrospective review of medical records data from Beijing Children's Hospital, Capital Medical University, China. METHODS:This study included 53 cases from July 2014 through December 2016. The data were tabulated and sta...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-020-03311-1
更新日期:2021-01-01 00:00:00
abstract::Mutations in the gamma-aminobutyric acid type A receptor (GABRG2) gene have been associated with generalized epilepsy, childhood absence epilepsy and febrile seizures. In the present study the authors investigated the association of polymorphism of the GABRG2 with simple febrile seizures (FS) in Egyptian children. Pol...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-011-0564-0
更新日期:2012-11-01 00:00:00
abstract::Juvenile dermatomyositis and juvenile scleroderma are rare multisystem autoimmune disorders. Although they share some pathognomonic hallmarks with adult onset myositis or scleroderma, there are significant differences in presentation, characteristics and associated features when the diseases present in childhood. In v...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-015-1907-z
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVES:To establish a technique for mutation identification and prenatal screening in confirmed cases of Canavan disease. METHOD:Mutations in ASPA gene were identified by sequencing. Six exons of ASPA gene were amplified using intronic primers flanking the exons and then sequenced on ABI 3500Dx automated unit. Thi...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-012-0862-1
更新日期:2013-01-01 00:00:00
abstract::With improved survival of very low birth infants in India, Retinopathy of Prematurity (ROP) is emerging as a significant problem. The most important risk factor in the pathogenesis of ROP is prematurity. Other factors like, problems with oxygenation frequent blood transfusions, sepsis and apnea have also been implicat...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-008-0011-z
更新日期:2008-01-01 00:00:00
abstract::Advances in immunosuppressive treatment as well as better monitoring and control of acute rejection have brought intestinal transplantation (ITx) into the realm of standard treatment for permanent intestinal failure. The results from the intestinal Transplant International Registry (www.intestinaltransplant.org) indic...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
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更新日期:2003-09-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-007-0023-0
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:To evaluate changes in annual blood transfusion requirements and complications after splenectomy in patients with β-thalassemia. METHODS:Forty post-splenectomy β-thalassemic patients aged 8-33 y, receiving regular blood transfusions and chelation therapy were included and non transfusion dependant patients ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-015-1792-5
更新日期:2015-12-01 00:00:00
abstract::Biotin Thiamine responsive Basal Ganglia Disease (BTBGD) is a rare treatable autosomal recessive metabolic disorder caused by mutations in SLC19A3 gene. It usually presents with encephalopathy and dystonia; if not treated, can progress to quadriparesis and death. Two Indian siblings born to a consanguineous marriage p...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-017-2471-5
更新日期:2018-02-01 00:00:00
abstract::In this review, the clinical features and management of most commonly encountered acyanotic, left-to-right shunt lesions are discussed. Patients with small defects, especially in childhood, are usually asymptomatic while moderate to large defects in infancy may present with symptoms. Hyperdynamic precordium, widely sp...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF02724429
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:To quantitatively summarize the evidence from observational studies on the relation between pediatric asthma and food allergy. METHODS:A literature search was conducted in Medline and EMBASE (August 2016). Two independent reviewers appraised the studies and extracted the estimates of interest. Methodological...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,meta分析
doi:10.1007/s12098-017-2326-0
更新日期:2017-08-01 00:00:00
abstract::Fifteen low birth weight premature infants with a diagnosis of PDA were administered 0·2 mg/kg of indomethacin orally, 3 doses at 12 hourly intervals. The results were compared with 18 prematures who were managed by fluid restriction (80-100 ml/kg/day) and decongestive therapy. Nine out of the 15 cases who received in...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02749534
更新日期:1986-07-01 00:00:00
abstract::Congenital heart diseases have varied presentations depending on the age of presentation. Regression of neonatal pulmonary hypertension and the timing of establishment of left to right shunt determines the onset of symptoms. Pre-tricuspid shunts generally remain asymptomatic during the childhood while large post-tricu...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-020-03251-w
更新日期:2020-05-01 00:00:00
abstract::The authors report a Japanese boy with severe pandemic influenza A(H1N1) 2009-associated pneumonia and deteriorating oxygenation. He dramatically recovered after the use of Airway Pressure Release Ventilation (APRV) mode. There was no improvement by using any conventional ventilation, however, APRV immediately led to ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-010-0280-1
更新日期:2011-03-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02722355
更新日期:2001-11-01 00:00:00
abstract::Rotary one of the largest non-government international organization focused mainly towards the up-liftment of the downtrodden worldwide, got involved in the Polio Eradication Program way back in 1979 with a five-year pledge to immunize about six million Philippine children from the crippling disease of poliomyelitis. ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02722705
更新日期:2002-08-01 00:00:00
abstract::Osteopetrosis is a collective term for a range of sclerosing bone diseases resulting from an absence or defective function of osteoclasts. The clinical expression is variable and includes skeletal, hematological and neurological manifestations. The common neurological manifestation includes cranial neuropathies involv...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-007-0070-6
更新日期:2007-04-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-014-1351-5
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:To evaluate genetic variations of innate immune system such as mannose binding lectin (MBL), Toll like receptor 4 (TLR4), CD14, LY96 (MD2) and Uroplakin 1B (UPK1B) genes in children with recurrent urinary tract infection (UTI). METHODS:The study included 30 children with recurrent UTI and 30 healthy controls...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-011-0399-8
更新日期:2011-10-01 00:00:00
abstract::Bronchopulmonary dysplasia (BPD) is a chronic lung disease associated with premature birth and characterized by early lung injury. Over the past 4 decades, there have been significant changes in its definition, pathology and radiological findings as well as management of BPD. Management of the acute phase and later st...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-007-0032-z
更新日期:2007-01-01 00:00:00
abstract::A cross-sectional study was conducted on the children of 146 randomly selected families in Abha, Saudi Arabia. Counting of teeth and examination for caries teeth of children under 12 years of age were done by family visits. The results showed that no child developed teeth before 5 months. By 12 months there were on an...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02722141
更新日期:1990-01-01 00:00:00
abstract::Antiperistaltic appendiceal conduit based on its vascular pedicle was used as hepaticoporto-appendico-jejunostomy (HAJ) in 9 infants with advanced stage of biliary atresia. Operative procedure was simple and less time consuming. The postoperative cholangitis was conspicuously absent, possibly due to the role played by...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02722419
更新日期:1989-07-01 00:00:00
abstract:OBJECTIVE:The study was performed to investigate the level of serum cardiac troponin I (cTnI), a specific marker for myocardial cell damage, in the acute rheumatic carditis (RC). METHODS:Twenty seven consecutive patients with acute RC and 23 healthy children were enrolled. RESULT:cTnI level in both groups showed no s...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02722592
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:To analyze the infection outbreaks, control measures and outcomes of the outbreak in the NICU of a tertiary care centre in the year 2018. METHODS:This study was conducted in a 30 bedded tertiary care NICU from January 2018 through December 2018. The study design was an Outbreak investigation, based on a prog...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-020-03201-6
更新日期:2020-05-01 00:00:00
abstract::The authors report a 14-y-old boy with insulin resistance, acanthosis nigricans, acral hypertrophy and muscle cramps. While there was a dramatic response of the muscle cramps to phenytoin therapy, some other features of metabolic syndrome did not respond to phenytoin therapy alone. ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-014-1503-7
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVES:To compare parent reported sleep behaviors of children with Autism Spectrum Disorders (ASD) and normal healthy controls and to examine the association of sleep disturbances with daytime behavioral difficulties in children with ASD. METHODS:Sixty ASD children (85% boys) (Mean age=6.1 y, SD=2.4) were recruite...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-018-2731-z
更新日期:2019-01-01 00:00:00