Nasopharyngeal carriage of Haemophilus influenzae.

Abstract:

OBJECTIVE:Nasopharyngeal colonization of Haemophilus influenzae (H. influenzae) in young children may be important in developing countries. METHOD:In this study, we screened school going children for carriage of H. influenzae. A total of 44 H. influenzae isolates out of a collection of 162 were characterized for biotypes, capsular serotypes and antibiotic resistance. RESULTS:A significant proportion of H. influenzae (25/44) isolates were serotype b. High antibiotic resistance was observed against commonly administered antibiotics like ampicillin (79%), chloramphenicol (20%), trimethoprim sulfamethoxazole (84%) and erythromycin (95%). Comparison of antibiotic resistance profile of nasopharyngeal isolates was observed to be correlated with those of H. influenzae from disease. CONCLUSION:Multidrug resistant nasopharyngeal H. influenzae in young healthy children may act as reservoir. Monitoring of antibiotic resistance among nasopharyngeal H. influenzae as a surrogate for invasive H. influenzae seems an attractive option.

journal_name

Indian J Pediatr

authors

Das BK,Arora NK,Mathur P,Ostwal P,Mandal S,Kabra SK,Kapil A,Lalitha MK,Thomas K

doi

10.1007/BF02723690

keywords:

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

775-7

issue

9

eissn

0019-5456

issn

0973-7693

journal_volume

69

pub_type

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