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eLife文献大全abstract::Nervous systems distinguish between self- and other-generated movements by monitoring discrepancies between planned and performed actions. To do so, corollary discharges are conveyed to sensory areas and gate expected reafference. Such gating is observed in neonatal rats during wake-related movements. In contrast, twi...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.18749
更新日期:2016-08-03 00:00:00
abstract::Toothed whales use sonar to detect, locate, and track prey. They adjust emitted sound intensity, auditory sensitivity and click rate to target range, and terminate prey pursuits with high-repetition-rate, low-intensity buzzes. However, their narrow acoustic field of view (FOV) is considered stable throughout target ap...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.05651
更新日期:2015-03-20 00:00:00
abstract::Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can undergo irreversible aggregation to the amyloid state. The dimer...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.10935
更新日期:2015-11-18 00:00:00
abstract::Understanding genome to phenotype linkages has been greatly enabled by genomic sequencing. However, most genome analysis is typically confined to the nuclear genome. We conducted a metabolomic QTL analysis on a reciprocal RIL population structured to examine how variation in the organelle genomes affects phenotypic va...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.00776
更新日期:2013-10-08 00:00:00
abstract::We analyzed 2898 scientific papers published between 1995 and 2017 in which two or more authors shared the first author position. For papers in which the first and second authors made equal contributions, mixed-gender combinations were most frequent, followed by male-male and then female-female author combinations. Fo...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.36399
更新日期:2019-01-29 00:00:00
abstract::β-Propellers arise through the amplification of a supersecondary structure element called a blade. This process produces toroids of between four and twelve repeats, which are almost always arranged sequentially in a single polypeptide chain. We found that new propellers evolve continuously by amplification from single...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49853
更新日期:2019-10-15 00:00:00
abstract::To improve chemical cross-linking of proteins coupled with mass spectrometry (CXMS), we developed a lysine-targeted enrichable cross-linker containing a biotin tag for affinity purification, a chemical cleavage site to separate cross-linked peptides away from biotin after enrichment, and a spacer arm that can be label...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.12509
更新日期:2016-03-08 00:00:00
abstract::Animals and humans replay neural patterns encoding trajectories through their environment, both whilst they solve decision-making tasks and during rest. Both on-task and off-task replay are believed to contribute to flexible decision making, though how their relative contributions differ remains unclear. We investigat...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.56911
更新日期:2020-06-17 00:00:00
abstract::Mitochondria support synaptic transmission through production of ATP, sequestration of calcium, synthesis of glutamate, and other vital functions. Surprisingly, less than 50% of hippocampal CA1 presynaptic boutons contain mitochondria, raising the question of whether synapses without mitochondria can sustain changes i...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.15275
更新日期:2016-12-19 00:00:00
abstract::Mood and anxiety disorders are the most prevalent psychiatric conditions and are exacerbated by stress. Recent studies have suggested cyclooxygenase-2 (COX-2) inhibition could represent a novel treatment approach or augmentation strategy for affective disorders including anxiety disorders and major depression. We show...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.14137
更新日期:2016-05-10 00:00:00
abstract::Studies in different animal model systems have revealed the impact of odors on immune cells; however, any understanding on why and how odors control cellular immunity remained unclear. We find that Drosophila employ an olfactory-immune cross-talk to tune a specific cell type, the lamellocytes, from hematopoietic-proge...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.60376
更新日期:2020-12-29 00:00:00
abstract::Vertebrate embryonic patterning depends on signaling from Nodal, a TGFβ superfamily member. There are three Nodal orthologs in zebrafish; southpaw directs left-right asymmetries, while squint and cyclops function earlier to pattern mesendoderm. TGFβ member Vg1 is implicated in mesoderm formation but the role of the ze...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.28635
更新日期:2017-11-15 00:00:00
abstract::Khoomei is a unique singing style originating from the republic of Tuva in central Asia. Singers produce two pitches simultaneously: a booming low-frequency rumble alongside a hovering high-pitched whistle-like tone. The biomechanics of this biphonation are not well-understood. Here, we use sound analysis, dynamic mag...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.50476
更新日期:2020-02-17 00:00:00
abstract::The TP53 tumor-suppressor gene is mutated in >50% of human tumors and Li-Fraumeni patients with germ line inactivation are predisposed to developing cancer. Here, we generated tp53 deleted zebrafish that spontaneously develop malignant peripheral nerve-sheath tumors, angiosarcomas, germ cell tumors, and an aggressive ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.37202
更新日期:2018-09-07 00:00:00
abstract::Protein aggregation appears to originate from partially unfolded conformations that are sampled through stochastic fluctuations of the native protein. It has been a challenge to characterize these fluctuations, under native like conditions. Here, the conformational dynamics of the full-length (23-231) mouse prion prot...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.44766
更新日期:2019-04-26 00:00:00
abstract::R-loops are features of chromatin consisting of a strand of DNA hybridized to RNA, as well as the expelled complementary DNA strand. R-loops are enriched at promoters where they have recently been shown to have important roles in modifying gene expression. However, the location of promoter-associated R-loops and the g...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.28306
更新日期:2017-10-26 00:00:00
abstract::TFIID-a complex of TATA-binding protein (TBP) and TBP-associated factors (TAFs)-is a central component of the Pol II promoter recognition apparatus. Recent studies have revealed significant downregulation of TFIID subunits in terminally differentiated myocytes, hepatocytes and adipocytes. Here, we report that TBP prot...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.08536
更新日期:2015-09-22 00:00:00
abstract::Human SEMAPHORIN 5A (SEMA5A) is an autism susceptibility gene; however, its function in brain development is unknown. In this study, we show that mouse Sema5A negatively regulates synaptogenesis in early, developmentally born, hippocampal dentate granule cells (GCs). Sema5A is strongly expressed by GCs and regulates d...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.04390
更新日期:2014-10-14 00:00:00
abstract::Autophagy has been linked to longevity in many species, but the underlying mechanisms are unclear. Using a GFP-tagged and a new tandem-tagged Atg8/LGG-1 reporter, we quantified autophagic vesicles and performed autophagic flux assays in multiple tissues of wild-type Caenorhabditis elegans and long-lived daf-2/insulin/...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.18459
更新日期:2017-07-04 00:00:00
abstract::Cerebellar climbing fiber activity encodes performance errors during many motor learning tasks, but the role of these error signals in learning has been controversial. We compared two motor learning paradigms that elicited equally robust putative error signals in the same climbing fibers: learned increases and decreas...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.02076
更新日期:2014-04-22 00:00:00
abstract::Ten countries have reported pfhrp2/pfhrp3 gene deletions since the first observation of pfhrp2-deleted parasites in 2012. In a previous study (Watson et al., 2017), we characterised the drivers selecting for pfhrp2/3 deletions and mapped the regions in Africa with the greatest selection pressure. In February 2018, the...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.40339
更新日期:2019-05-02 00:00:00
abstract::Although individuals of many species inexorably age, a number of observations established that the rate of aging is modulated in response to a variety of mild stresses. Here, we investigated how heat stress promotes longevity in yeast. We show that upon growth at higher temperature, yeast cells relax the retention of ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.28329
更新日期:2017-12-28 00:00:00
abstract::Variation in the presentation of hereditary immunodeficiencies may be explained by genetic or environmental factors. Patients with mutations in HOIL1 (RBCK1) present with amylopectinosis-associated myopathy with or without hyper-inflammation and immunodeficiency. We report that barrier-raised HOIL-1-deficient mice exh...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.04494
更新日期:2015-01-20 00:00:00
abstract::Plasmodium falciparum causes malaria in humans with over 450,000 deaths annually. The asexual blood stage involves invasion of erythrocytes by merozoites, in which they grow and divide to release daughter merozoites, which in turn invade new erythrocytes perpetuating the cycle responsible for malaria. A key step in me...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.21347
更新日期:2017-02-14 00:00:00
abstract::Chemosensory neurons extract information about chemical cues from the environment. How is the activity in these sensory neurons transformed into behavior? Using Caenorhabditis elegans, we map a novel sensory neuron circuit motif that encodes odor concentration. Primary neurons, AWC(ON) and AWA, directly detect the foo...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.10181
更新日期:2015-09-22 00:00:00
abstract::Using knowledge of the structure of the world to infer value is at the heart of model-based reasoning and relies on a circuit that includes the orbitofrontal cortex (OFC). Some accounts link this to the representation of biological significance or value by neurons in OFC, while other models focus on the representation...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.30373
更新日期:2018-03-07 00:00:00
abstract::Using computer simulations, we generate cell-specific 3D chromosomal structures and compare them to recently published chromatin structures obtained through microscopy. We demonstrate using machine learning and polymer physics simulations that epigenetic information can be used to predict the structural ensembles of m...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.60312
更新日期:2020-10-13 00:00:00
abstract::Visual perception and imagery rely on similar representations in the visual cortex. During perception, visual activity is characterized by distinct processing stages, but the temporal dynamics underlying imagery remain unclear. Here, we investigated the dynamics of visual imagery in human participants using magnetoenc...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.33904
更新日期:2018-05-29 00:00:00
abstract::Genetic programming and neural activity drive synaptic remodeling in developing neural circuits, but the molecular components that link these pathways are poorly understood. Here we show that the C. elegans Degenerin/Epithelial Sodium Channel (DEG/ENaC) protein, UNC-8, is transcriptionally controlled to function as a ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.14599
更新日期:2016-07-12 00:00:00
abstract::An individual may need to take different actions to the same stimulus in different situations to achieve a given goal. The selection of the appropriate action hinges on the previously learned associations between stimuli, actions, and outcomes in the situations. Here, using a go/no-go paradigm and a symmetrical reward...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.43281
更新日期:2019-04-04 00:00:00