Abstract:
:Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can undergo irreversible aggregation to the amyloid state. The dimers therefore must disassociate into monomers prior to forming amyloid fibrils. Here we identify ligands that inhibit amyloid formation by stabilizing the Mcg light chain variable domain dimer and shifting the equilibrium away from the amyloid-prone monomer.
journal_name
Elifejournal_title
eLifeauthors
Brumshtein B,Esswein SR,Salwinski L,Phillips ML,Ly AT,Cascio D,Sawaya MR,Eisenberg DSdoi
10.7554/eLife.10935subject
Has Abstractpub_date
2015-11-18 00:00:00pages
e10935issn
2050-084Xjournal_volume
4pub_type
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