Zika Virus Associated Pathology and Antigen Presence in the Testicle in the Absence of Sexual Transmission During Subacute to Chronic Infection in a Mouse Model.

abstract：:The global incidence of obesity has led to an increasing need for understanding the molecular mechanisms that drive this epidemic and its comorbidities. Quantitative real-time RT-PCR (RT-qPCR) is the most reliable and widely used method for gene expression analysis. The selection of suitable reference genes (RGs) is c...

journal_title：Scientific reports

authors： Perez LJ,Rios L,Trivedi P,D'Souza K,Cowie A,Nzirorera C,Webster D,Brunt K,Legare JF,Hassan A,Kienesberger PC,Pulinilkunnil T

更新日期：2017-06-15 00:00:00

abstract：:The physiological, biochemical and functional differences between oxidative and glycolytic muscles play important roles in human metabolic health and in animal meat quality. To explore these differences, we determined the genome-wide landscape of DNA methylomes and their relationship with the mRNA and miRNA transcript...

journal_title：Scientific reports

authors： Shen L,Du J,Xia Y,Tan Z,Fu Y,Yang Q,Li X,Tang G,Jiang Y,Wang J,Li M,Zhang S,Zhu L

更新日期：2016-08-26 00:00:00

abstract：:Advances in microfluidics technology has enabled many discoveries on microbial mechanisms and phenotypes owing to its exquisite controls over biological and chemical environments. However, emulating accurate ecologically relevant flow environments (e.g. microbes around a rising oil droplet) in microfluidics remains ch...

journal_title：Scientific reports

authors： White AR,Jalali M,Sheng J

更新日期：2019-09-24 00:00:00

abstract：:Tetrastatin, a 230 amino acid sequence from collagen IV, was previously demonstrated to inhibit melanoma progression. In the present paper, we identified the minimal active sequence (QKISRCQVCVKYS: QS-13) that reproduced the anti-tumor effects of whole Tetrastatin in vivo and in vitro on melanoma cell proliferation, m...

journal_title：Scientific reports

authors： Lambert E,Fuselier E,Ramont L,Brassart B,Dukic S,Oudart JB,Dupont-Deshorgue A,Sellier C,Machado C,Dauchez M,Monboisse JC,Maquart FX,Baud S,Brassart-Pasco S

更新日期：2018-06-29 00:00:00

abstract：:Backward wave with anti-parallel phase and group velocities is one of the basic properties associated with negative refraction and sub-diffraction image that have attracted considerable interest in the context of photonic metamaterials. It has been predicted theoretically that some plasmonic structures can also suppor...

journal_title：Scientific reports

authors： Liu X,Feng Y,Zhu B,Zhao J,Jiang T

更新日期：2016-02-04 00:00:00

abstract：:We aimed to investigate the potential of preoperative mammographic breast density (MBD) as a prognostic factor in breast cancer. Data of 969 patients with primary breast cancer were analyzed. We defined low MBD as fatty or fibroglandular breast, and high MBD as heterogeneously dense or extremely dense breast, respecti...

journal_title：Scientific reports

authors： Hwang KT,Chu AJ,Kim J,Lee JY,Chang JH,Oh S,Kim YA,Jung J,Oh B

更新日期：2018-10-30 00:00:00

abstract：:Diabrotica virgifera virgifera LeConte, the western corn rootworm (WCR), is the most destructive pest of maize in North America, and has recently spread across central Europe. Its subterranean larval stages are hard to reach with pesticides and it has evolved resistance to conventional management practices. The applic...

journal_title：Scientific reports

authors： Jaffuel G,Imperiali N,Shelby K,Campos-Herrera R,Geisert R,Maurhofer M,Loper J,Keel C,Turlings TCJ,Hibbard BE

更新日期：2019-02-28 00:00:00

abstract：:We show that H-bonded host-guest systems associate in ionic liquids (ILs), pure salts with melting point below room temperature, in which dipole-dipole electrostatic interactions should be negligible in comparison with dipole-charge interactions. Binding constants (Ka) obtained from titrations of four H-bonded host-gu...

journal_title：Scientific reports

authors： Naranjo T,Álvarez-Asencio R,Pedraz P,Nieto-Ortega B,Silva SM,Burzurí E,Rutland MW,Pérez EM

更新日期：2020-09-22 00:00:00

abstract：:To pattern electrical metal contacts, electron beam lithography or photolithography are commonly utilized, and these processes require polymer resists with solvents. During the patterning process the graphene surface is exposed to chemicals, and the residue on the graphene surface was unable to be completely removed b...

journal_title：Scientific reports

authors： Tien DH,Park JY,Kim KB,Lee N,Seo Y

更新日期：2016-05-12 00:00:00

abstract：:Across the planet the biogeographic distribution of human cultural diversity tends to correlate positively with biodiversity. In this paper we focus on the biogeographic distribution of mammal species and human cultural diversity. We show that not only are these forms of diversity similarly distributed in space, but t...

journal_title：Scientific reports

authors： Hamilton MJ,Walker RS,Kempes CP

更新日期：2020-11-12 00:00:00

abstract：:The housefly (Musca domestica L.) lives in close association with its microbiota and its symbionts are suggested to have pivotal roles in processes such as metabolism and immune response, but it is unclear how the profound physiological changes during ontogeny affect the housefly's associated microbiota and their meta...

journal_title：Scientific reports

authors： de Jonge N,Michaelsen TY,Ejbye-Ernst R,Jensen A,Nielsen ME,Bahrndorff S,Nielsen JL

更新日期：2020-05-12 00:00:00

abstract：:We herein describe a simple, sensitive and specific method for analysis of circulating microRNAs (miRNA), termed S-Poly(T) Plus real-time PCR assay. This new method is based on our previously developed S-Poly(T) method, in which a unique S-Poly(T) primer is used during reverse-transcription to increase sensitivity and...

journal_title：Scientific reports

authors： Niu Y,Zhang L,Qiu H,Wu Y,Wang Z,Zai Y,Liu L,Qu J,Kang K,Gou D

更新日期：2015-10-13 00:00:00

abstract：:Pigeon pea is an important legume infested by a plethora of insect pests amongst which gram pod borer Helicoverpa armigera is very prominent. Imparting resistance to this insect herbivore is of global importance in attaining food security. Expression of insecticidal crystal proteins (ICP) in diverse crops has led to i...

journal_title：Scientific reports

authors： Singh S,Kumar NR,Maniraj R,Lakshmikanth R,Rao KYS,Muralimohan N,Arulprakash T,Karthik K,Shashibhushan NB,Vinutha T,Pattanayak D,Dash PK,Kumar PA,Sreevathsa R

更新日期：2018-06-11 00:00:00

abstract：:Cancer immunotherapy, including immune checkpoint inhibitors, exerts beneficial effects in cancer patients. However, immune checkpoint inhibitors are only advantageous for a limited population of cancer patients. Therefore, companion diagnostics are needed in order to identify patients for whom these therapies are eff...

journal_title：Scientific reports

authors： Iwahori K,Shintani Y,Funaki S,Yamamoto Y,Matsumoto M,Yoshida T,Morimoto-Okazawa A,Kawashima A,Sato E,Gottschalk S,Okumura M,Kumanogoh A,Wada H

更新日期：2019-02-22 00:00:00

abstract：:The arthropod-transmitted chikungunya virus (CHIKV) causes a flu-like disease that is characterized by incapacitating arthralgia. The re-emergence of CHIKV and the continual risk of new epidemics have reignited research in CHIKV pathogenesis. Virus-specific antibodies have been shown to control virus clearance, but an...

journal_title：Scientific reports

authors： Lum FM,Couderc T,Chia BS,Ong RY,Her Z,Chow A,Leo YS,Kam YW,Rénia L,Lecuit M,Ng LFP

更新日期：2018-01-30 00:00:00

abstract：:Tyrosine hydroxylase (TH), the initial enzyme in the melanin pathway, catalyzes tyrosine conversion into Dopa. Although expression and regulation of TH have been shown to affect cuticle pigmentation in insects, no direct functional studies to date have focused on the specific physiological processes involving the enzy...

journal_title：Scientific reports

authors： Qiao L,Du M,Liang X,Hao Y,He X,Si F,Mei T,Chen B

更新日期：2016-07-15 00:00:00

abstract：:Soils are an important source of nitrogen in many of the world's cropping systems. Especially in low-input production systems, nitrogen release from soil organic matter turn-over is the major part of the crop's nitrogen supply and research suggests that this process is significantly affected by changes in climate. The...

journal_title：Scientific reports

authors： Nendel C,Melzer D,Thorburn PJ

更新日期：2019-04-10 00:00:00

abstract：:Scrophularia striata, commonly known as figwort, is one of the most important medicinal plants that mainly grows in cold regions of the Zagros Mountains (West of Iran). Although the chemical composition of this plant species has not yet been explored, people living in Ilam province (W Iran) have used it for many years...

journal_title：Scientific reports

authors： Zargoosh Z,Ghavam M,Bacchetta G,Tavili A

更新日期：2019-11-05 00:00:00

abstract：:Patients hospitalised with COVID-19 have a high mortality. Identification of patients at increased risk of adverse outcome would be important, to allow closer observation and earlier medical intervention for those at risk, and to objectively guide prognosis for friends and family of affected individuals. We conducted ...

journal_title：Scientific reports

authors： Gue YX,Tennyson M,Gao J,Ren S,Kanji R,Gorog DA

更新日期：2020-12-07 00:00:00

abstract：:The present work presents and discusses the results of a comprehensive study on the bioactive properties of Nb-substituted silicate glass derived from 45S5 bioglass. In vitro and in vivo experiments were performed. We undertook three different types of in vitro analyses: (i) investigation of the kinetics of chemical r...

journal_title：Scientific reports

authors： Souza L,Lopes JH,Encarnação D,Mazali IO,Martin RA,Camilli JA,Bertran CA

更新日期：2018-08-24 00:00:00

abstract：:We demonstrate a comprehensive quantitative analysis of vector beam states (VBSs) by using a vector field reconstruction (VFR) technique integrating interferometry and imaging polarimetry, where the analysis is given by a cylindrically polarized Laguerre-Gaussian (LG) mode expansion of VBSs. From test examples of cyli...

journal_title：Scientific reports

authors： Suzuki M,Yamane K,Oka K,Toda Y,Morita R

更新日期：2019-07-10 00:00:00

abstract：:Helicobacter pylori cagA-positive strain delivers the CagA oncoprotein into gastric epithelial cells and at the same time elicits stomach inflammation. To experimentally investigate the pathophysiological interplay between CagA and inflammation, transgenic mice systemically expressing the bacterial cagA gene were trea...

journal_title：Scientific reports

authors： Suzuki N,Murata-Kamiya N,Yanagiya K,Suda W,Hattori M,Kanda H,Bingo A,Fujii Y,Maeda S,Koike K,Hatakeyama M

更新日期：2015-05-06 00:00:00

abstract：:The organismic unit of heterocyst-forming cyanobacteria is a filament of communicating cells connected by septal junctions, proteinaceous structures bridging the cytoplasms of contiguous cells. This distinct bacterial organization is preserved during cell division. In Anabaena, deletion of the zipN gene could not be s...

journal_title：Scientific reports

authors： Camargo S,Picossi S,Corrales-Guerrero L,Valladares A,Arévalo S,Herrero A

更新日期：2019-02-26 00:00:00

abstract：:In 2018, the World Health Organization identified the Zika virus (ZIKV) as a pathogen that should be prioritized for public health research due to its epidemic potential. In this study, whole-genome sequencing (WGS) of travel-acquired ZIKV infections was used to examine the limitations of phylogenetic analysis. WGS an...

journal_title：Scientific reports

authors： Kamelian K,Montoya V,Olmstead A,Dong W,Harrigan R,Morshed M,Joy JB

更新日期：2019-11-11 00:00:00

abstract：:In southeastern China (SEC), the precipitation amount produced by the East Asian summer monsoon (EASM) is almost equivalent to that during the non-summer monsoon (NSM) period, both of them significantly affecting agriculture and socioeconomy. Here, we present a seasonally-resolved stalagmite δ18O record (δ18Os) for th...

journal_title：Scientific reports

authors： Zhang H,Cheng H,Spötl C,Cai Y,Sinha A,Tan L,Yi L,Yan H,Kathayat G,Ning Y,Li X,Zhang F,Zhao J,Edwards RL

更新日期：2018-08-17 00:00:00

abstract：:Interference of two combined white light beams produces Newton colors if one of the beams is retarded relative to the other by from 400 nm to 2000 nm. In this case the corresponding interfering spectral components are added as two scalars at the beam combination. If the retardance is below 400 nm the two-beam interfer...

journal_title：Scientific reports

authors： Shribak M

更新日期：2015-11-27 00:00:00

abstract：:The aim of the study was to investigate the effect of 2nd-line pazopanib on the different CTCs subpopulations in SCLC patients and evaluate the clinical relevance of their changes. Different CTCs subpopulations were evaluated before pazopanib initiation (n = 56 patients), after one-cycle (n = 35) and on disease progre...

journal_title：Scientific reports

authors： Messaritakis I,Politaki E,Koinis F,Stoltidis D,Apostolaki S,Plataki M,Dermitzaki EK,Georgoulias V,Kotsakis A

更新日期：2018-02-02 00:00:00

abstract：:Oligomers populated during the early amyloid aggregation process are more toxic than mature fibrils, but pinpointing the exact toxic species among highly dynamic and heterogeneous aggregation intermediates remains a major challenge. β-barrel oligomers, structurally-determined recently for a slow-aggregating peptide de...

journal_title：Scientific reports

authors： Sun Y,Ge X,Xing Y,Wang B,Ding F

更新日期：2018-07-09 00:00:00

abstract：:RNA-binding proteins are key regulators of post-transcriptional processes such as alternative splicing and mRNA stabilization. Rbm24 acts as a regulator of alternative splicing in heart and skeletal muscle, and is essential for sarcomere assembly. Homozygous inactivation of Rbm24 in mice disrupts cardiac development a...

journal_title：Scientific reports

authors： de Groot NE,van den Hoogenhof MMG,Najafi A,van der Made I,van der Velden J,Beqqali A,Pinto YM,Creemers EE

更新日期：2020-05-06 00:00:00

abstract：:Dementia is a neurocognitive disorder characterized by a progressive memory loss and impairment in cognitive and functional abilities. Autophagy and mitophagy are two important cellular processes by which the damaged intracellular components are degraded by lysosomes. To investigate the contribution of autophagy and m...

journal_title：Scientific reports

authors： Castellazzi M,Patergnani S,Donadio M,Giorgi C,Bonora M,Bosi C,Brombo G,Pugliatti M,Seripa D,Zuliani G,Pinton P

更新日期：2019-12-27 00:00:00