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Protective properties of the aqueous extract of saffron (Crocus sativus L.) in ischemic stroke, randomized clinical trial.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Crocus sativus L. has been used throughout the world in traditional medicine as a treatment for neurological disorders such as depression. Growing attention is currently being paid to the use of neuroprotective agents in ischemic strokes. AIM OF THE STUDY:This study assed the effect of saffron as a neuroprotective natural product in cerebral ischemia in human. STUDY DESIGN:Patients with acute ischemic stroke were randomly allocated to receive either routine stroke care (control group, n = 20) or routine care plus aqueous extract of saffron capsule (200 mg/day) (saffron-treated group, n = 19). Both groups were monitored during their four-day hospital stay and the three-month follow-up period. The groups were compared in terms of short- and long-term effects of saffron capsules using the National Institute of Health Stoke Scale (NIHSS), Barthel Scale, and serum neuron specific enolase (NSE), Brain-derived neurotrophic factor (BDNF), S100 levels. RESULTS:Based on the NIHSS, the severity of stroke during the first four days was significantly lower in the saffron-treated group than in the control group (P < 0.05). Compared to the levels on the first day, serum NSE and s100 levels were significantly decreased and BDNF concentration was increased in the saffron-treated group on the fourth day. Also, our results showed there was a negative significant non-linear cubic regression between BDNF concentration and score of NIHSS. At the end of the three-month follow-up period, the mean Barthel index was significantly higher in the saffron-treated group than in the control group (P < 0.001). CONCLUSION:The results of this study confirmed the short and long-term neuroprotective effects of aqueous extract of saffron on ischemic stroke in humans.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Asadollahi M,Nikdokht P,Hatef B,Sadr SS,Sahraei H,Assarzadegan F,Pirzad Jahromi G

doi

10.1016/j.jep.2019.111833

subject

Has Abstract

pub_date

2019-06-28 00:00:00

pages

111833

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(18)34490-8

journal_volume

238

pub_type

杂志文章,随机对照试验

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Protective properties of the aqueous extract of saffron (Crocus sativus L.) in ischemic stroke, randomized clinical trial.