Abstract：
:Successful adaptation to passive hyperthermia requires continual adjustment of circulation, which is mediated mainly by the autonomic nervous system. The goal of this study was to explore the alterations in spontaneous cardiovagal baroreflex sensitivity (BRS) during exposure to a hot environment. To continuously follow changes in core body temperature (Tc), haemodynamics, and BRS, male Wistar-Kyoto rats were implanted with telemetric transmitters. BRS at an ambient temperature of 23 °C was not steady but oscillated with a maximum power in the range of 0.02-0.2 Hz. Exposure to hot air immediately shifted the distribution of BRS to higher values, although Tc remained unchanged (37.2 (0.3) °C), and the average BRS changed from 1.3 (0.3) to 3 (1.4) ms.mmHg-1, p < 0.0001. The degree of initial cardiovagal baroreflex sensitization explained 57% of the variability in the time to the onset of arterial pressure decline (p = 0.0114). With an increasing Tc (>38.8 (0.6) °C), BRS non-linearly declined, but haemodynamic parameters remained stable even above a Tc of 42 °C when the cardiovagal baroreflex was virtually non-operative. Abrupt full desensitization of the cardiovagal baroreflex with a muscarinic blocker did not induce arterial pressure decline. Our data indicate that a progressive decrease in BRS during passive hyperthermia does not induce haemodynamic instability. The positive association between initial cardiovagal baroreflex sensitization and the time to the onset of arterial pressure decline may reflect the potential protective role of parasympathetic activation during exposure to a hot environment.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Turcani M,Ghadhanfar Edoi
10.1038/s41598-019-39172-8subject
Has Abstractpub_date
2019-02-22 00:00:00pages
2586issue
1issn
2045-2322pii
10.1038/s41598-019-39172-8journal_volume
9pub_type
杂志文章abstract：:Multidisciplinary applications of four-coordinate boron(III) complexes make them very attractive and challenging research field in chemistry, biology and material sciences. The dual role played by boron atom in stabilising the chelate ligand and enhancing the π-conjugation makes them very useful as luminescent materia...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00236-2
更新日期：2017-03-21 00:00:00
abstract：:Natural and anthropogenic stressors can cause phase shifts from coral-dominated to algal-dominated states. In the Caribbean, over-fishing of large herbivorous fish and disease among the long-spined urchin, Diadema, have facilitated algal growth on degraded reefs. We found that diminutive species of urchin and parrotfi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39670
更新日期：2017-01-05 00:00:00
abstract：:High frequency oscillations (HFOs) are bursts of neural activity in the range of 80 Hz or higher, recorded from intracranial electrodes during epileptiform discharges. HFOs are a proposed biomarker of epileptic brain tissue and may also be useful for seizure forecasting. Despite such clinical utility of HFOs, the spat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76138-7
更新日期：2020-11-05 00:00:00
abstract：:Protein phosphorylation is one of the most prevalent and well-understood protein modifications. Oxidation of protein-bound methionine, which has been traditionally perceived as an inevitable damage derived from oxidative stress, is now emerging as another modification capable of regulating protein activity during stre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40403
更新日期：2017-01-12 00:00:00
abstract：:Articular cartilage (AC) lacks the ability to self-repair and cell-based approaches, primarily based on using chondrocytes and mesenchymal stem cells (MSCs), are emerging as effective technology to restore cartilage functionality, because cells synergic functionality may support the maintenance of chondrogenic phenoty...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51070-7
更新日期：2019-10-10 00:00:00
abstract：:Porphyry systems supply most copper and significant gold to our economy. Recent studies indicate that they are frequently associated with high Sr/Y magmatic rocks, but the meaning of this association remains elusive. Understanding the association between high Sr/Y magmatic rocks and porphyry-type deposits is essential...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00685
更新日期：2012-01-01 00:00:00
abstract：:Metastasis is generally considered a characteristic of malignant tumors. Herein, we describe a patient with more than one hundred discrete Spitz nevi scattered all over her skin. Molecular analysis from three of the lesions identified a ROS1 fusion oncogene with identical genomic breakpoints, indicating that the nevi ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73264-0
更新日期：2020-10-01 00:00:00
abstract：:The accumulation of fat, especially in visceral sites, is a significant risk factor for several chronic diseases with altered cardiometabolic homeostasis. We studied how intensive long-term weight loss and subsequent weight regain affect physiological changes, by longitudinally interrogating the lipid metabolism and w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40107-6
更新日期：2019-03-05 00:00:00
abstract：:The high metabolic activity associated with endurance flights and intense fuelling of migrant birds may produce large quantities of reactive oxygen species, which cause oxidative damage. Yet it remains unknown how long-lived birds prepare for oxidative challenges prior to extreme flights. We combined blood measurement...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54057-6
更新日期：2019-11-26 00:00:00
abstract：:All species face the important adaptive problem of efficiently locating high-quality nutritional resources. We explored whether human spatial cognition is enhanced for high-calorie foods, in a large multisensory experiment that covertly tested the location memory of people who navigated a maze-like food setting. We fo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72570-x
更新日期：2020-10-08 00:00:00
abstract：:As an emerging sterilization technology, cold atmospheric plasma offers a dry, non-thermal, rapid process that is minimally damaging to a majority of substrates. However, the mechanisms by which plasma interacts with living cells are poorly understood and the plasma generation apparatuses are complex and resource-inte...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35166-0
更新日期：2018-11-12 00:00:00
abstract：:The arrival of Neolithic culture in North Africa, especially domestic animals has been essentially documented from archaeological records. As the data relative to sheep are scarce, we studied the genetic relationship between Moroccan sheep breeds and Mediterranean ones using the sequencing of 628 bp of the mitochondri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67246-5
更新日期：2020-06-23 00:00:00
abstract：:Programmed cell death 1 (PD-1) monoclonal antibodies have been approved by regulatory agencies for the treatment of various types of cancer, and the mechanism involves the restoration of T cell functions. We report herein the X-ray crystal structure of a fully human monoclonal antibody mAb059c fragment antigen-binding...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54231-w
更新日期：2019-11-28 00:00:00
abstract：:The ecosystem of the Source Region of Yangtze River (SRYR) is highly susceptible to climate change. In this study, the spatial-temporal variation of NPP from 2000 to 2014 was analyzed, using outputs of Carnegie-Ames-Stanford Approach model. Then the correlation characteristics of NPP and climatic factors were evaluate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80494-9
更新日期：2021-01-14 00:00:00
abstract：:The characterization of network community structure has profound implications in several scientific areas. Therefore, testing the algorithms developed to establish the optimal division of a network into communities is a fundamental problem in the field. We performed here a highly detailed evaluation of community detec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02216
更新日期：2013-01-01 00:00:00
abstract：:Mt. Spurr is the largest active volcano in Alaska of high explosive potential. The most recent activity, including two recent magmatic eruptions in 1953 and 1992, has occurred via the flanking Crater Peak. From 2004 to 2006, strong seismicity, gas flux, and heating were observed in the summit area, which had remained ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35453-w
更新日期：2018-11-30 00:00:00
abstract：:There are only few studies that explore the ecological consequences of forest management on several organism groups. We studied the short-term effects of four forestry treatments including preparation cutting, clear-cutting, retention tree group and gap-cutting in a temperate managed forest on the assemblage structure...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35159-z
更新日期：2018-11-19 00:00:00
abstract：:We have designed a versatile and sensitive liquid chromatographic (LC) system, featuring a monolithic trap column and a very narrow (10 μm ID) fused silica open tubular liquid chromatography (OTLC) separation column functionalized with C18-groups, for separating a wide range of molecules (from small metabolites to int...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37507
更新日期：2016-11-29 00:00:00
abstract：:Selective filtration of gas, water, and liquid or gaseous oil is essential to prevent possible environmental pollution and machine/facility malfunction in oil-based industries. Novel materials and structures able to selectively and efficiently filter liquid and vapor in various types of solutions are therefore in cont...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14321
更新日期：2015-09-23 00:00:00
abstract：:The human hepatoma-derived growth factor (HDGF), containing the chromatin-associated N-terminal PWWP domain capable of binding the SMYD1 promoter, participates in various cellular processes and is involved in human cancers. We report the first crystal structures of the human HDGF PWWP domain (residues 1-100) in a comp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18510-8
更新日期：2018-01-10 00:00:00
abstract：:In order to study the molecular differences between type 2 diabetes mellitus (T2DM) and T2DM with depression (DD), we aimed to screen the differential expression of lncRNA, mRNA, and circRNA in the blood of patients with T2DM and DD. Based on the self-rating depression scale (SDS), patient health questionnaire 9 (PHQ9...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47077-9
更新日期：2019-07-24 00:00:00
abstract：:The accelerated discovery of disease-related genes emerging from genomic studies has strained the capacity of traditional genetically engineered mouse models (GEMMs) to provide in-vivo validation. Direct, somatic, genetic engineering approaches allow for accelerated and flexible genetic manipulation and represent an a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11061
更新日期：2015-06-05 00:00:00
abstract：:Optical coherence tomography angiography (OCTA) seems not to image the choroidal blood flow pattern in the normal individual because of the OCT light attenuation. Our purpose in the current study was to visualize the large choroidal blood flow pattern after subtraction of the choriocapillaris projection artifact in no...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34102-6
更新日期：2018-10-24 00:00:00
abstract：:Tunneling nanotubes (TNTs) are actin-based membranous structures bridging distant cells for intercellular communication. We define roles for TNTs in stress adaptation and treatment resistance in prostate cancer (PCa). Androgen receptor (AR) blockade and metabolic stress induce TNTs, but not in normal prostatic epithel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44346-5
更新日期：2019-05-24 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-28391-0
更新日期：2018-07-11 00:00:00
abstract：:Nitric oxide synthase like enzyme (NOS-like enzyme), which produces nitric oxide, participates in many biological processes. However it remains unidentified and highly controversial that plants do possess a NOS-like enzyme. In this paper, a novel arginine analogue NP1 was designed and developed for the direct identifi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32630
更新日期：2016-09-02 00:00:00
abstract：:A novel process to control light through the coupling modulation by surface acoustic wave (SAW) is presented in an optical micro resonator. An optical waveguide modulator of a racetrack resonator on silicon-on-insulator (SOI) technology is took as an example to explore the mechanism. A finite-difference time-domain (F...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30681
更新日期：2016-08-03 00:00:00
abstract：:The relationship among the single nucleotide polymorphisms (SNPs) of the C-X-C motif chemokine ligand 12 gene (CXCL12) and the serum lipid profiles in the Chinese population has rarely been described, especially in somewhat old-fashioned and isolated Maonan minority. The goal of the current study was to elucidate the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55725-3
更新日期：2019-12-20 00:00:00
abstract：:Anaerobic digestion is a common technology to biologically stabilize wasted solids produced in municipal wastewater treatment. Its efficiency is usually evaluated by calculating the reduction in volatile solids, which assumes no biomass growth associated with digestion. To determine whether this assumption is valid an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34090
更新日期：2016-09-26 00:00:00
abstract：:The monitoring and early detection of abnormalities or variations in the cardiac cycle functionality are very critical practices and have significant impact on the prevention of heart diseases and their associated complications. Currently, in the field of biomedical engineering, there is a growing need for devices cap...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37093
更新日期：2016-11-17 00:00:00
