Abstract:
:We applied circular dichroism (CD) spectral analysis to obtain the secondary structure of the DNA repair protein XRCC4, with a focus on its C-terminus. Using synchrotron radiation as a light source across a wide range of wavelengths, including vacuum ultraviolet (UV) light from 180 to 200 nm and UV light from 200 to 240 nm, we determined the secondary structure composition of the full-length protein, including its C-terminus, which had not yet been -the focus of crystallography studies, though it contains several phosphorylation sites. The secondary structures inferred using the obtained CD spectra indicate that the C-terminus is composed of a substantial fraction of turns with a few unordered and alpha-helix structures and almost no beta-strands. The C-terminus is likely to form a characteristic secondary structure with turns as a main component, and its DNA repair function is likely regulated by the structural change induced by phosphorylation of the terminus.
journal_name
Radiat Prot Dosimetryjournal_title
Radiation protection dosimetryauthors
Nishikubo K,Izumi Y,Matsumoto Y,Fujii K,Matsuo K,Yokoya Adoi
10.1093/rpd/ncy275subject
Has Abstractpub_date
2019-05-01 00:00:00pages
36-39issue
1-2eissn
0144-8420issn
1742-3406pii
5250488journal_volume
183pub_type
杂志文章abstract::Beginning in the 16th century, what was later found to be radon was thought to be causing sickness among miners. During the first decades of the 20th century, exposure to radon was seen as being healthy. During the 1940s, 1950s and 1960s researchers thought that the gamma radiation in residences could produce genetic ...
journal_title:Radiation protection dosimetry
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journal_title:Radiation protection dosimetry
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journal_title:Radiation protection dosimetry
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journal_title:Radiation protection dosimetry
pub_type: 杂志文章
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abstract::The Fukushima Daiichi Nuclear Power Plant (FDNPP) accident has resulted in the deposition of radioactive contamination of soils mainly by (134)Cs and (137)Cs. The contaminated areas are of a great concern since external radiation may lead to significant long-term doses to humans and animals. External dose rate above g...
journal_title:Radiation protection dosimetry
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journal_title:Radiation protection dosimetry
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journal_title:Radiation protection dosimetry
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journal_title:Radiation protection dosimetry
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journal_title:Radiation protection dosimetry
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journal_title:Radiation protection dosimetry
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journal_title:Radiation protection dosimetry
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abstract::Owing to the introduction of new diagnostic procedures, such as computed tomography (CT), positron emission tomography (PET) and single photon emission computed tomography (SPECT), the individual dose caused by medical exposures has grown rapidly in the last years. This is especially a subject to radiation protection ...
journal_title:Radiation protection dosimetry
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abstract::Radiation protection in medicine is becoming more and more important with increasing wider use of X-rays, documentation of effects besides the potential for long-term carcinogenic effects. With computed tomography (CT) likely to become sub-mSv in coming years, positron emission tomography (PET), single photon emission...
journal_title:Radiation protection dosimetry
pub_type: 杂志文章
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abstract::At least 10% of inhabitants in the Czech Republic are supplied with water from private sources (private wells, boreholes). With the increasing cost of water, the number of people using their own sources of drinking water will be likely to increase. According to the Decree of the State Office for Nuclear Safety about t...
journal_title:Radiation protection dosimetry
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journal_title:Radiation protection dosimetry
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abstract::In vitro dose-response calibration curves for (60)Co gamma rays have been established for unstable chromosome aberrations in human peripheral blood lymphocytes. The observed dose-response data were fitted to a linear quadratic model. The calibration curve parameters were used to estimate the equivalent whole-body dose...
journal_title:Radiation protection dosimetry
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journal_title:Radiation protection dosimetry
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journal_title:Radiation protection dosimetry
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journal_title:Radiation protection dosimetry
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