Abstract:
:In reviewing the tissue effects of low-dose radiation (1) absorbed dose to tissue is replaced by the sum of energy deposited with track events in cell-equivalent tissue micromasses, i.e. with microdose hits, in the number of exposed micromasses and (2) induced cell damage and adaptive protection are related to microdose hits in exposed micromasses for a given radiation quality. DNA damage increases with the number of microdose hits. They also can induce adaptive protection, mainly against endogenous DNA damage. This protection involves cellular defences, DNA repair and damage removal. With increasing numbers of low linear energy transfer (LET) microdose hits in exposed micromasses, adaptive protection first tends to outweigh damage and then (above 200 mGy) fails and largely disappears. These experimental data predict that cancer risk coefficients derived by epidemiology at high-dose irradiation decline at low doses and dose rates when adaptive protection outdoes DNA damage. The dose-risk function should include both linear and non-linear terms at low doses.
journal_name
Radiat Prot Dosimetryjournal_title
Radiation protection dosimetryauthors
Feinendegen LEdoi
10.1093/oxfordjournals.rpd.a006197keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
337-46issue
4eissn
0144-8420issn
1742-3406journal_volume
104pub_type
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