THE DECADE OF THE RABiT (2005-15).

Abstract:

:The RABiT (Rapid Automated Biodosimetry Tool) is a dedicated Robotic platform for the automation of cytogenetics-based biodosimetry assays. The RABiT was developed to fulfill the critical requirement for triage following a mass radiological or nuclear event. Starting from well-characterized and accepted assays we developed a custom robotic platform to automate them. We present here a brief historical overview of the RABiT program at Columbia University from its inception in 2005 until the RABiT was dismantled at the end of 2015. The main focus of this paper is to demonstrate how the biological assays drove development of the custom robotic systems and in turn new advances in commercial robotic platforms inspired small modifications in the assays to allow replacing customized robotics with 'off the shelf' systems. Currently, a second-generation, RABiT II, system at Columbia University, consisting of a PerkinElmer cell::explorer, was programmed to perform the RABiT assays and is undergoing testing and optimization studies.

journal_name

Radiat Prot Dosimetry

authors

Garty G,Turner HC,Salerno A,Bertucci A,Zhang J,Chen Y,Dutta A,Sharma P,Bian D,Taveras M,Wang H,Bhatla A,Balajee A,Bigelow AW,Repin M,Lyulko OV,Simaan N,Yao YL,Brenner DJ

doi

10.1093/rpd/ncw172

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

201-206

issue

1-3

eissn

0144-8420

issn

1742-3406

pii

ncw172

journal_volume

172

pub_type

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