Oh Heavy Burden: Recognizing the Risk of Venous Thromboembolism in Women Undergoing Assisted Reproduction.

abstract：:Induction of procoagulant factors in malignant cells is considered to be the major cause of coagulation disorders in cancer. Thrombomodulin (TM), a negative regulator of coagulation was also found to be expressed in cancer cells. We report here evidence for another anticoagulant, the endothelial cell protein C recepto...

journal_title：Thrombosis and haemostasis

authors： Tsuneyoshi N,Fukudome K,Horiguchi S,Ye X,Matsuzaki M,Toi M,Suzuki K,Kimoto M

更新日期：2001-02-01 00:00:00

abstract：:Tissue factor pathway inhibitor (TFPI) plays a crucial role in haemostasis by regulating TF-induced initiation of coagulation. Since it is expressed by endothelial and trophoblastic cells, TFPI is of particular importance at the placental level and might be involved in the occurrence of gestational vascular complicati...

journal_title：Thrombosis and haemostasis

authors： Ittel A,Bretelle F,Gris JC,Chau C,Sébahoun G,Boubli L,Arnoux D

更新日期：2011-01-01 00:00:00

abstract：:The recombinant plasminogen activator BM 06.022 consists of the kringle 2 and the protease domains of human t-PA and is unglycosylated because of the expression in Escherichia coli. The thrombolytic and pharmacokinetic properties as well as the hemostasis effects of BM 06.022 were investigated in the rabbit model of j...

journal_title：Thrombosis and haemostasis

authors： Martin U,Fischer S,Kohnert U,Opitz U,Rudolph R,Sponer G,Stern A,Strein K

更新日期：1991-05-06 00:00:00

abstract：:It is known that thrombosis is a leading cause of vascular access failure and that the formation of thrombus requires platelets. The activation of platelets induces the increase in intracellular Ca 2(+) levels ([Ca(2+)](i)) leading to aggregation and thrombosis. We compared the platelet [Ca(2+)](i) before and after st...

journal_title：Thrombosis and haemostasis

authors： Chou KJ,Jan CR,Lee PT,Chen CL,Chung HM,Hwang YY,Chou JD,Fang HC

更新日期：2004-09-01 00:00:00

abstract：:In the last decade, the endothelial cell protein C/activated protein C receptor (EPCR) has received considerable attention. The role initially attributed to EPCR, i.e. the enhancement of protein C (PC) activation by the thrombin-thrombomodulin complex on the surface of the large vessels, although important, did not go...

journal_title：Thrombosis and haemostasis

authors： Montes R,Puy C,Molina E,Hermida J

更新日期：2012-05-01 00:00:00

abstract：:The fibrinolytic system was studied in 96 patients with type I diabetes mellitus. Patients were grouped according to their degree of retinopathy; 38 patients with no evidence of retinopathy, 28 patients with background retinopathy and 30 patients with proliferative retinopathy. Thirty healthy individuals served as con...

journal_title：Thrombosis and haemostasis

authors： Ostermann H,Tschöpe D,Greber W,Meyer-Rüsenberg HW,van de Loo J

更新日期：1992-10-05 00:00:00

abstract：:In The Netherlands, a particular coagulometer method for prothrombin time (PT) determination with reduced sample and reagent volumes is used by 62% of the laboratories controlling oral anticoagulant therapy. This "micro-method" has been calibrated against the manual tilt-tube technique for PT determination by six Dutc...

journal_title：Thrombosis and haemostasis

authors： Peters RH,van den Besselaar AM,Olthuis FM

更新日期：1989-04-25 00:00:00

abstract：:A disintegrin and metalloproteases (ADAMs) are membrane-bound enzymes responsible for the shedding or cleavage of various cell surface molecules, such as adhesion molecules, cytokines/chemokines and growth factors. This shedding can result in the release of soluble proteins that can exert agonistic or antagonistic fun...

journal_title：Thrombosis and haemostasis

authors： van der Vorst EPC,Weber C,Donners MMPC

更新日期：2018-07-01 00:00:00

abstract：:ADAMTS13 dysfunction has been involved in the pathogenesis of Thrombotic Thrombocytopenic Purpura. This disorder occurs more frequently in women and, in 13% of them, is associated with pregnancy. However, there is little information on the protease behaviour in normal pregnancy. We studied von Willebrand factor and AD...

journal_title：Thrombosis and haemostasis

authors： Sánchez-Luceros A,Farías CE,Amaral MM,Kempfer AC,Votta R,Marchese C,Salviú MJ,Woods AI,Meschengieser SS,Lazzari MA

更新日期：2004-12-01 00:00:00

abstract：:A fibrinolysis inhibitor was purified in serum from post-traumatic patients by the use of flat bed electrofocusing of serum desalted by gel chromatography followed by affinity chromatography on a column of matrix-linked plasminogen. Disc gel electrophoresis yielded one protein band. The inhibitor protein was also foun...

journal_title：Thrombosis and haemostasis

authors： Bagge L,Björk I,Saldeen T,Wallin R

更新日期：1978-02-28 00:00:00

abstract：:Factor VIII inhibitors in mild haemophilia are uncommon and the management of such patients is controversial. The development of a persistently high responding F VIII inhibitor in a mild haemophiliac is reported and the behaviour of the inhibitor discussed in the context of the various therapeutic regimes employed for...

journal_title：Thrombosis and haemostasis

authors： Kesteven PJ,Holland LJ,Lawrie AS,Savidge GF

更新日期：1984-08-31 00:00:00

abstract：:Emicizumab, a bispecific monoclonal antibody, bridges activated factor IX (FIXa) and FX, replacing the function of missing FVIIIa to restore effective hemostasis in persons with hemophilia A (PwHA). Here we assess pharmacokinetic (PK) and pharmacodynamic (PD) biomarkers in PwHA with FVIII inhibitors in the Phase III H...

journal_title：Thrombosis and haemostasis

authors： Schmitt C,Adamkewicz JI,Xu J,Petry C,Catalani O,Young G,Negrier C,Callaghan MU,Levy GG

更新日期：2020-10-21 00:00:00

abstract：:In consecutive patients with suspected venous thromboembolism the interobserver variability of the SimpliRED D-dimer test was evaluated by two observers who independently scored one plate, the between assay variation was performed simultaneously by a third independent observer, who assessed a second plate. The biologi...

journal_title：Thrombosis and haemostasis

authors： Turkstra F,van Beek EJ,Büller HR

更新日期：1998-01-01 00:00:00

abstract：:Thirty-two patients with acute, proximal-vein thrombosis were treated with heparin and alteplase (0.25 versus 0.5 mg/kg/24 h during 3-7 days) in a randomized, double-blind, multicenter, European (ETTT) trial. The treatment resulted in a decrease of the venographic Marder's score from 18 (6-25) to 13 (2-24) units (medi...

journal_title：Thrombosis and haemostasis

authors： Bounameaux H,Banga JD,Bluhmki E,Coccheri S,Fiessinger JN,Haarmann W,Lockner D,Mahler F,Ninet J,Schneider PA

更新日期：1992-03-02 00:00:00

abstract：:Seven mouse monoclonal antibodies have been produced against human melanoma tissue plasminogen activator (t-PA). They were specifically bound to 125I t-PA but not 125I urokinase (u-PA) and inhibited t-PA, but not u-PA, activity in plasminogen-rich 125I fibrin wells. Three of the antibodies directly inhibited the amido...

journal_title：Thrombosis and haemostasis

authors： MacGregor IR,Micklem LR,James K,Pepper DS

更新日期：1985-02-18 00:00:00

abstract：:Management strategies for patients with atrial fibrillation (AF) in association with valvular heart disease (VHD) have been less informed by randomized trials, which have largely focused on ‘non-valvular AF’ patients. Thromboembolic risk also varies according to valve lesion and may also be associated with CHA2DS2-VAS...

journal_title：Thrombosis and haemostasis

authors： Lip GYH,Collet JP,de Caterina R,Fauchier L,Lane DA,Larsen TB,Marin F,Morais J,Narasimhan C,Olshansky B,Pierard L,Potpara T,Sarrafzadegan N,Sliwa K,Varela G,Vilahur G,Weiss T,Boriani G,Rocca B

更新日期：2017-12-01 00:00:00

abstract：:There is little information on the clinical outcome of patients with venous thromboembolism and renal insufficiency. RIETE is an ongoing, prospective registry of consecutive patients with acute, objectively confirmed, symptomatic deep vein thrombosis (DVT) or pulmonary embolism (PE). In this analysis we analyzed the t...

journal_title：Thrombosis and haemostasis

authors： Falgá C,Capdevila JA,Soler S,Rabuñal R,Sánchez Muñoz-Torrero JF,Gallego P,Monreal M,RIETE Investigators.

更新日期：2007-10-01 00:00:00

abstract：:Thirty-one individuals from 18 unrelated families with antithrombin deficiency have been identified as having a single point mutation within codon 384 (13268 GCA-->TCA) resulting in an alanine to serine substitution. Six families (11 individuals) were identified by the screening of individuals with thromboembolic dise...

journal_title：Thrombosis and haemostasis

authors： Perry DJ,Daly ME,Tait RC,Walker ID,Brown K,Beauchamp NJ,Preston FE,Gyde H,Harper PL,Carrell RW

更新日期：1998-02-01 00:00:00

abstract：:Advanced electronic alerts (eAlerts) and computerised physician order entry (CPOE) increase adequate thromboprophylaxis orders among hospitalised medical patients. It remains unclear whether eAlerts maintain their efficacy over time, after withdrawal of continuing medical education (CME) on eAlerts and on thromboproph...

journal_title：Thrombosis and haemostasis

authors： Beeler PE,Kucher N,Blaser J

更新日期：2011-10-01 00:00:00

abstract：:Although, the main physiological role of monocytes is attributed to innate immunity (that is, phagocytosis) and the development of tissue macrophages and dendritic cells, the pathophysiological role of these goes far behind these (simplistic) limits. Indeed, monocytes constitute a major source of blood tissue factor, ...

journal_title：Thrombosis and haemostasis

authors： Shantsila E,Lip GY

更新日期：2009-11-01 00:00:00

abstract：:In a placebo-controlled trial healthy volunteers and patients with hyperlipoproteinemias types II and IV received orally vitamin E at doses of 300 mg and 600 mg daily for 2 weeks. Serum tocopherol levels increased two-fold, but serum concentrations of total lipids, cholesterol, triglycerides, ceruloplasmin and transfe...

journal_title：Thrombosis and haemostasis

authors： Szczeklik A,Gryglewski RJ,Domagala B,Dworski R,Basista M

更新日期：1985-08-30 00:00:00

abstract：:Recombinant activated factor VII (rFVIIa; NovoSeven®) is a heterogeneously glycosylated serine protease used for treatment of haemophiliacs with inhibitors. The drug substance contains a subpopulation consisting of ~20% of rFVIIa molecules which are unsialylated and consists of carbohydrate moieties with terminally ex...

journal_title：Thrombosis and haemostasis

authors： Seested T,Nielsen HM,Christensen EI,Appa RS

更新日期：2010-12-01 00:00:00

abstract：:Thrombomodulin (TM) is an endothelial glycoprotein that functions as a thrombin cofactor in the activation of protein C. Recent evidence has revealed that TM has unique effects on cellular proliferation, adhesion, and inflammation. We examined TM expression in the arterial remodeling process with different shear condi...

journal_title：Thrombosis and haemostasis

authors： Li YH,Hsieh CY,Wang DL,Chung HC,Liu SL,Chao TH,Shi GY,Wu HL

更新日期：2007-04-01 00:00:00

abstract：:alpha-Granule protein storage is important for producing platelets with normal haemostatic function. The low to undetectable levels of several megakaryocyte-synthesized alpha-granule proteins in normal plasma suggest megakaryocytes are important to sequester these proteins in vivo. alpha-Granule protein storage in vit...

journal_title：Thrombosis and haemostasis

authors： Veljkovic DK,Cramer EM,Alimardani G,Fichelson S,Massé JM,Hayward CP

更新日期：2003-11-01 00:00:00

abstract：:Cystic fibrosis (CF) is characterized by a persistent inflammatory state, which can be secondary to chronic pulmonary infection and may affect vascular endothelium. We measured circulating levels of von Willebrand factor (vWF), tissue-plasminogen activator (t-PA), and P-selectin in 20 CF patients and 20 healthy subjec...

journal_title：Thrombosis and haemostasis

authors： Romano M,Collura M,Lapichino L,Pardo F,Falco A,Chiesa PL,Caimi G,Davì G

更新日期：2001-12-01 00:00:00

abstract：:This study examines the relationship between plasma Plasminogen Activator Inhibitor-1 (PAI-1) activity and the PAI-1 4G/5G polymorphism, and their association with the risk of myocardial infarction (MI). Furthermore, this study explores whether a high level of PAI-1 or whether the PAI-1 4G/5G polymorphism synergistica...

journal_title：Thrombosis and haemostasis

authors： Leander K,Wiman B,Hallqvist J,Sten-Linder M,de Faire U,Stockholm Heart Epidemiology Program.

更新日期：2003-06-01 00:00:00

abstract：:Moderate or severe paravalvular regurgitation after transcatheter aortic valve implantation (TAVI) is frequently associated with a loss of high-molecular-weight multimers of von Willebrand factor (VWF) and a reduced VWF collagen-binding capacity. It is unclear whether this phenomenon can also be observed in patients w...

journal_title：Thrombosis and haemostasis

authors： Pawlitschek F,Keyl C,Zieger B,Budde U,Beyersdorf F,Neumann FJ,Stratz C,Nührenberg TG,Trenk D

更新日期：2018-01-01 00:00:00

abstract：:An enzyme immuno assay was developed to measure complexes of tissue-type plasminogen activator (t-PA) with C1-inhibitor in order to study the role of C1-inhibitor as an inhibitor of t-PA in plasma. In vitro experiments with melanoma and recombinant t-PA learned that purified C1-inhibitor reacts with both single chain ...

journal_title：Thrombosis and haemostasis

authors： Huisman LG,van Griensven JM,Kluft C

更新日期：1995-03-01 00:00:00

abstract：:The effect of urinary protein C inhibitor (uPCI) on disseminated intravascular coagulation (DIC) was investigated using an experimental DIC in rats. uPCI (0.5 and 1.0 mg/kg) was continuously administrated into the left femoral vein of the rats with lipopolysaccharide (50 mg/kg)-induced DIC. In all doses, uPCI signific...

journal_title：Thrombosis and haemostasis

authors： Fujita M,Izutani W,Komurasaki Y

更新日期：2000-07-01 00:00:00

abstract：:To determine a possible relation of changes in plasma levels of plasminogen activator inhibitor 1 (PAI-1) and tissue plasminogen activator (t-PA) to the development of coronary restenosis after successful coronary angioplasty (PTCA), we followed 104 patients with a low grade residual stenosis after PTCA (less than 30%...

journal_title：Thrombosis and haemostasis

authors： Huber K,Jörg M,Probst P,Schuster E,Lang I,Kaindl F,Binder BR

更新日期：1992-02-03 00:00:00