Expression and anticoagulant function of the endothelial cell protein C receptor (EPCR) in cancer cell lines.

abstract：:Limited data are available on the role of monocytes in cardiac repair. In the present study, we evaluated the dynamic alterations of monocytes with reparative and angiogenic potential in patients with myocardial infarction(MI). Reparative CXCR4+ monocytes, and CD34+ and KDR+ monocytes with angiogenic potential derived...

journal_title：Thrombosis and haemostasis

authors： Shantsila E,Tapp LD,Wrigley BJ,Montoro-García S,Lip GY

更新日期：2013-02-01 00:00:00

abstract：:In the last decade, the endothelial cell protein C/activated protein C receptor (EPCR) has received considerable attention. The role initially attributed to EPCR, i.e. the enhancement of protein C (PC) activation by the thrombin-thrombomodulin complex on the surface of the large vessels, although important, did not go...

journal_title：Thrombosis and haemostasis

authors： Montes R,Puy C,Molina E,Hermida J

更新日期：2012-05-01 00:00:00

abstract：:Tamoxifen is a known anti-cancer drug and established estrogen receptor modulator. Few clinical studies have earlier implicated the drug in thrombotic complications attributable to lower anti-thrombin and protein S levels in plasma. However, action of tamoxifen on platelet signalling machinery has not been elucidated ...

journal_title：Thrombosis and haemostasis

authors： Nayak MK,Singh SK,Roy A,Prakash V,Kumar A,Dash D

更新日期：2011-10-01 00:00:00

abstract：:Platelet aggregation and fibrinogen binding in whole blood, induced either by ADP or by a 14 amino acid peptide mimicking an N-terminal region of the platelet thrombin receptor (TRP, thrombin receptor activating peptide), have been studied with blood from different species. Aggregation was assessed by counting the num...

journal_title：Thrombosis and haemostasis

authors： Cook NS,Zerwes HG,Tapparelli C,Powling M,Singh J,Metternich R,Hagenbach A

更新日期：1993-09-01 00:00:00

abstract：:The structures of bovine and human vWF were compared by proteolysis with Staphylococcus aureus V8 protease and rattlesnake venom Protease I. Fragments were analyzed for chain composition, heparin binding, collagen binding, platelet agglutinating activity and recognition by a panel of monoclonal antibodies which reacte...

journal_title：Thrombosis and haemostasis

authors： Bakhshi MR,Kirby EP

更新日期：1990-06-28 00:00:00

abstract：:We found that intracellular Ca2+ concentration ([Ca2+]i) increased during ristocetin-induced agglutination of aequorin loaded platelets resuspended in plasma. Chelation of extracellular Ca2+ had no effect on platelet clumping, but delayed and greatly reduced Ca2+ increase, indicating that it derived for the most part ...

journal_title：Thrombosis and haemostasis

authors： Bertolino G,Noris P,Spedini P,Balduini CL

更新日期：1995-04-01 00:00:00

abstract：:Human protein S (HPS) has three potential N-linked glycosylation sites at Asn458, 468, 489. To study the role of glycosylation at these sites, PCR mutagenesis was used to abolish the consensus sequence of each N-linked glycosylation site (Asn458-->Gln, Ser460-->Gly; Asn468-->Gln, Thr470-->Gly; Asn489-->Gln, Thr491-->G...

journal_title：Thrombosis and haemostasis

authors： Lu D,Xie RL,Rydzewski A,Long GL

更新日期：1997-06-01 00:00:00

abstract：:Novel P2Y12 inhibitors are in development to overcome the occurrence of atherothrombotic events associated with poor responsiveness to the widely used P2Y12 inhibitor clopidogrel. Cangrelor is an intravenously administered P2Y12 inhibitor that does not need metabolic conversion to an active metabolite for its antiplat...

journal_title：Thrombosis and haemostasis

authors： Bouman HJ,van Werkum JW,Rudez G,Leebeek FW,Kruit A,Hackeng CM,Ten Berg JM,de Maat MP,Ruven HJ

更新日期：2010-02-01 00:00:00

abstract：:It was the study objective to determine whether glycaemic control affects the extent of platelet inhibition by thienopyridines as assessed by vasodilator-stimulated phosphoprotein flow cytometry (VASP-FCT) in patients with diabetes mellitus (DM) undergoing percutaneous coronary intervention (PCI) during acute coronary...

journal_title：Thrombosis and haemostasis

authors： Morel O,El Ghannudi S,Hess S,Reydel A,Crimizade U,Jesel L,Radulescu B,Wiesel ML,Gachet C,Ohlmann P

更新日期：2012-08-01 00:00:00

abstract：:Serine proteases are proteolytic enzymes with an active serine residue in their catalytic site. Kallikreins are a subgroup of the serine protease family and are known to have diverse physiological functions. The human tissue kallikrein gene family has now been fully characterized and includes 15 members, clustered in ...

journal_title：Thrombosis and haemostasis

authors： Yousef GM,Diamandis EP

更新日期：2003-07-01 00:00:00

abstract：:Defibrotide is an antithrombotic drug which enhances prostacyclin production and activates fibrinolytic system. The aim of this study was to investigate the improvement of walking distance in patients with intermittent claudication treated with defibrotide. DICLIS was a double blind, placebo-controlled study which inc...

journal_title：Thrombosis and haemostasis

authors： Violi F,Marubini E,Coccheri S,Nenci GG

更新日期：2000-05-01 00:00:00

abstract：:The terms glycoprotein IV (GPIV) and glycoprotein IIIb (GPIIIb) have been used interchangeably and reports in the literature have indicated this glycoprotein as having a molecular weight variously described as either 88,000 or 97,000, a fast anodal mobility on crossed electrophoresis and either 13 or less than 1 methi...

journal_title：Thrombosis and haemostasis

authors： Yamamoto N,de Romeuf C,Tandon NN,Jamieson GA

更新日期：1990-02-19 00:00:00

abstract：:A new genetic test has been developed for detection of the mutation known as factor V Leiden. The test employs heteroduplex technology and comprises a single PCR reaction followed immediately by PCR product analysis. It therefore represents the minimum practical route from blood/tissue sample to genetic result. A coho...

journal_title：Thrombosis and haemostasis

authors： Bowen DJ,Standen GR,Granville S,Bowley S,Wood NA,Bidwell J

更新日期：1997-01-01 00:00:00

abstract：:The effects on the haemoglobin level of low dose aspirin and of low intensity oral anticoagulation with warfarin separately and in combination have been established in men aged between 45 and 69 at high risk of ischaemic heart disease. The findings confirm that combined treatment with warfarin and aspirin (WA) leads t...

journal_title：Thrombosis and haemostasis

authors： Meade TW,Howarth DJ,Brennan PJ

更新日期：1994-03-01 00:00:00

abstract：:Bleeding time and platelet function tests were performed on 31 patients with progressive chronic renal failure (CRF) due to non-immunological (urological) causes, and compared with 22 healthy controls. Patients were classified as mild (plasma creatinine less than 300 mumol/l), moderate (300-600 mumol/l) or severe rena...

journal_title：Thrombosis and haemostasis

authors： Gordge MP,Faint RW,Rylance PB,Neild GH

更新日期：1988-08-30 00:00:00

abstract：:A method is described for the purification of antiactivator from bovine euglobulin-free serum by means of gelfiltration and ion exchange chromatography. The purified antiactivator has no antifibrinolytic activity. It has a molecular weight of about 115,000 and it appears to be a gamma globulin. The dissociation consta...

journal_title：Thrombosis and haemostasis

authors： Nanninga LB,Guest MM

更新日期：1979-10-31 00:00:00

abstract：:We have investigated the influence of long term oral anticoagulants (OAC) upon the plasma levels of prothrombin fragment 1 + 2 (F1 + 2), of thrombin-antithrombin III complexes (TAT) and of D-Dimer in 20 patients affected by a proximal deep vein thrombosis (DVT) diagnosed by ultrasonic duplex scanning. Patients (63 +/-...

journal_title：Thrombosis and haemostasis

authors： Elias A,Bonfils S,Daoud-Elias M,Gauthier B,Sié P,Boccalon H,Boneu B

更新日期：1993-04-01 00:00:00

abstract：:The effect of selective activation of platelet prostaglandin (PG) E2 receptor subtype EP2 or EP4 on platelet aggregation remains to be determined. In platelets prepared from wild-type mice (WT platelets), high concentrations of PGE2 inhibited platelet aggregation induced by U-46619, a thromboxane receptor agonist. How...

journal_title：Thrombosis and haemostasis

authors： Kuriyama S,Kashiwagi H,Yuhki K,Kojima F,Yamada T,Fujino T,Hara A,Takayama K,Maruyama T,Yoshida A,Narumiya S,Ushikubi F

更新日期：2010-10-01 00:00:00

abstract：:Fibrinolytic therapy can result in rapid lysis of deep vein thrombi (DVT), but its use is limited by the failure of many patients to respond and by the increased risk of bleeding complications in comparison with anticoagulant therapy alone. Treatment could be improved by the ability to select patients most likely to r...

journal_title：Thrombosis and haemostasis

authors： Francis CW,Totterman S

更新日期：1995-03-01 00:00:00

abstract：:Increased fibrinogen concentration is a well known phenomenon following acute ischemic stroke. However, the natural course of this hyperfibrinogenemia is uncertain. We aimed to clarify whether it is of a transient or more persistent nature in patients who harbor an underlying morbid biology of atherothrombo-inflammati...

journal_title：Thrombosis and haemostasis

authors： Shenhar-Tsarfaty S,Ben Assayag E,Bova I,Shopin L,Cohen M,Berliner S,Shapira I,Bornstein NM

更新日期：2008-01-01 00:00:00

abstract：:The behavior of 125I-labeled recombinant hirudin towards the uninjured and de-endothelialized rabbit aorta wall has been studied in vitro and in vivo to determine its usefulness as an indicator of thrombin activity associated with the aorta wall. Thrombin adsorbed to either sulfopropyl-Sephadex or heparin-Sepharose bo...

journal_title：Thrombosis and haemostasis

authors： Hatton MW,Ross-Ouellet B

更新日期：1994-04-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation occurs in vascular obstructive events such as atherosclerosis and restenosis. We previously showed that Notch receptors are induced in smooth muscle cells during vascular remodeling. Our goal was to determine the mechanisms employed by Notch signaling to regulate prolif...

journal_title：Thrombosis and haemostasis

authors： Havrda MC,Johnson MJ,O'Neill CF,Liaw L

更新日期：2006-09-01 00:00:00

abstract：:The aim was to investigate the perioperative risk of ischaemic and bleeding events in patients with coronary stents undergoing cardiac and non-cardiac surgery and how these outcomes are affected by the perioperative use of oral antiplatelet therapy. This was a multicentre, retrospective, observational study conducted ...

journal_title：Thrombosis and haemostasis

authors： Rossini R,Musumeci G,Capodanno D,Lettieri C,Limbruno U,Tarantini G,Russo N,Calabria P,Romano M,Inashvili A,Sirbu V,Guagliumi G,Valsecchi O,Senni M,Gavazzi A,Angiolillo DJ

更新日期：2015-02-01 00:00:00

abstract：:Measurement of heparin ex vivo is usually with reference to standard curve prepared with a "spiked" normal human plasma pool (NHP). When the calibration curve was prepared by addition of heparin to whole blood before plasma separation, although the linear relationship was maintained the slope was increased in comparis...

journal_title：Thrombosis and haemostasis

authors： Melissari E,Thye C,Scully MF,Kakkar VV

更新日期：1989-04-25 00:00:00

abstract：:Novel strategies for a tailored risk prediction in chronic heart failure (CHF) are crucial to identify patients at very high risk for an improved patient management and to specify treatment regimens. Endothelial progenitor cells (EPCs) are an important endogenous repair mechanism with the ability to counteract endothe...

journal_title：Thrombosis and haemostasis

authors： Koller L,Hohensinner P,Sulzgruber P,Blum S,Maurer G,Wojta J,Hülsmann M,Niessner A

更新日期：2016-08-01 00:00:00

abstract：:A native fucosylated glycosaminoglycan from sea cucumber Holothuria fuscopunctata (nHG), mainly branched with Fuc3S4S, exhibited potent anticoagulant activity by intrinsic tenase iXase (FIXa-FVIIIa complex) and antithrombin-dependent factor IIa (FIIa) inhibition, but also had the effects of FXII activation and platele...

journal_title：Thrombosis and haemostasis

authors： Zhou L,Gao N,Sun H,Xiao C,Yang L,Lin L,Yin R,Li Z,Zhang H,Ji X,Zhao J

更新日期：2020-04-01 00:00:00

abstract：:Inherited thrombophilic states are associated with an increased risk for deep vein thrombosis (DVT), but whether they are also risk factors for superficial vein thrombosis (SVT) is uncertain. We assessed the risk conferred by inherited thrombophilic states in patients with a first episode of SVT in whom the coexistenc...

journal_title：Thrombosis and haemostasis

authors： Martinelli I,Cattaneo M,Taioli E,De Stefano V,Chiusolo P,Mannucci PM

更新日期：1999-10-01 00:00:00

abstract：:The increased risk for deep vein thrombosis (DVT) after orthopaedic surgery has been well documented as well as hypercoagulable state during both total hip arthroplasty (THA) and total knee replacement (TKR). To investigate the influence of the surgical procedure [posterolateral (PL) or lateral (L) approach for THA, u...

journal_title：Thrombosis and haemostasis

authors： Fedi S,Gori AM,Falciani M,Cellai AP,Aglietti P,Baldini A,Vena LM,Prisco D,Abbate R,Gensini GF

更新日期：1999-06-01 00:00:00

abstract：:Compared to second generation, the use of third generation oral contraceptives has been associated with an increased risk of venous thrombosis especially in women with the factor V Leiden mutation. To find an explanation for these risk differences we investigated the effects of desogestrel- and levonorgestrel-containi...

journal_title：Thrombosis and haemostasis

authors： Kemmeren JM,Algra A,Meijers JC,Bouma BN,Grobbee DE

更新日期：2002-02-01 00:00:00

abstract：:The 50 laboratories of the Netherlands Federation of Thrombosis Services, covering a population of 9 million and responsible for the laboratory control of approximately 150,000 patients under oral anticoagulation, have participated since 1974 in a voluntary external and internal quality control program. The external p...

journal_title：Thrombosis and haemostasis

authors： van Dijk-Wierda CA,Hermans J,Loeliger EA,Roos J

更新日期：1977-06-30 00:00:00