Improvement of walking distance by defibrotide in patients with intermittent claudication--results of a randomized, placebo-controlled study (the DICLIS study). Defibrotide Intermittent CLaudication Italian Study.

abstract：:Measurement of heparin ex vivo is usually with reference to standard curve prepared with a "spiked" normal human plasma pool (NHP). When the calibration curve was prepared by addition of heparin to whole blood before plasma separation, although the linear relationship was maintained the slope was increased in comparis...

journal_title：Thrombosis and haemostasis

authors： Melissari E,Thye C,Scully MF,Kakkar VV

更新日期：1989-04-25 00:00:00

abstract：:Heparin-induced thrombocytopenia (HIT), a relatively common complication of heparin therapy, results of platelet activation, via the receptor for the Fc domain of IgG (FcgammaRIIa), by heparin-dependent-antibodies, commonly directed against the heparin-platelet factor 4 (H-PF4) antigenic complex. Our strategy was to u...

journal_title：Thrombosis and haemostasis

authors： Khairy M,Lasne D,Brohard-Bohn B,Aiach M,Rendu F,Bachelot-Loza C

更新日期：2001-06-01 00:00:00

abstract：:Moderate or severe paravalvular regurgitation after transcatheter aortic valve implantation (TAVI) is frequently associated with a loss of high-molecular-weight multimers of von Willebrand factor (VWF) and a reduced VWF collagen-binding capacity. It is unclear whether this phenomenon can also be observed in patients w...

journal_title：Thrombosis and haemostasis

authors： Pawlitschek F,Keyl C,Zieger B,Budde U,Beyersdorf F,Neumann FJ,Stratz C,Nührenberg TG,Trenk D

更新日期：2018-01-01 00:00:00

abstract：:Vascular endothelial cells perform many differentiated functions in processes such as angiogenesis, hemostasis, and inflammation. The number of recognized differentiated functions has increased rapidly in recent years, but there may be many more still unrecognized. The purpose of this study is to estimate the fraction...

journal_title：Thrombosis and haemostasis

authors： Rieber AJ,Marr HS,Comer MB,Edgell CJ

更新日期：1993-05-03 00:00:00

abstract：:Carboxypeptidase U (CPU, EC 3.4.17.20) is a recently described basic carboxypeptidase which circulates in plasma as the zymogen procarboxypeptidase U (proCPU). In the current study, we report on the presence of the proCPU/CPU system in different mammalian species--pig, guinea pig, dog, mouse, rabbit, rat and human. Th...

journal_title：Thrombosis and haemostasis

authors： Schatteman KA,Goossens FJ,Scharpé SS,Hendriks DF

更新日期：1999-12-01 00:00:00

abstract：:To investigate pituitary effects on the vitamin K-dependent coagulation factors, female rats were hypophysectomized (hypox) and treated with growth hormone (GH), cortisone, thyroxine, vitamin K, or saline. After 11 days of treatment, the prothrombin time, platelet count, and factors II, VII, IX, and X were determined....

journal_title：Thrombosis and haemostasis

authors： Sävendahl LS,Grankvist K,Engström KG

更新日期：1995-04-01 00:00:00

abstract：:Abdominal aortic aneurysm (AAA) evolution is unpredictable, and there is no therapy except surgery for patients with an aortic size> 5 cm (large AAA). We aimed to identify new potential biomarkers that could facilitate prognosis and treatment of patients with AAA. A differential quantitative proteomic analysis of plas...

journal_title：Thrombosis and haemostasis

authors： Burillo E,Lindholt JS,Molina-Sánchez P,Jorge I,Martinez-Pinna R,Blanco-Colio LM,Tarin C,Torres-Fonseca MM,Esteban M,Laustsen J,Ramos-Mozo P,Calvo E,Lopez JA,Vega de Ceniga M,Michel JB,Egido J,Andrés V,Vazquéz J,Meilha

更新日期：2015-06-01 00:00:00

abstract：:Individuals with lupus anticoagulants (LA) are at risk for thromboembolism (TE). Chronic inflammation is an important characteristic in LA patients which may dispose for TE. Platelets play a key role in inflammation and TE. We therefore investigated gene polymorphisms as well as plasma levels of platelet receptors as ...

journal_title：Thrombosis and haemostasis

authors： Bugert P,Pabinger I,Stamer K,Vormittag R,Skeate RC,Wahi MM,Panzer S

更新日期：2007-04-01 00:00:00

abstract：:Cellular adhesion molecules also known as selectins promote recruitment of inflammatory cells into the arterial wall where they interact with lipid particles leading subsequently to plaque formation. The intercellular adhesion molecule-1 (ICAM-1), the vascular cell adhesion molecule-1 (VCAM-1) and the endothelial-leuk...

journal_title：Thrombosis and haemostasis

authors： Hoke M,Winter MP,Wagner O,Exner M,Schillinger M,Arnold Z,Mlekusch W,Maurer G,Koppensteiner R,Minar E,Goliasch G

更新日期：2015-08-31 00:00:00

abstract：:The introduction of venography into patient care was a major advance because it was the first accurate method for the diagnosis of DVT. Compression ultrasound has since become the preferred test for patients with suspected DVT because, unlike venography, it is simple, non-invasive and widely available. Venography has ...

journal_title：Thrombosis and haemostasis

authors： Hirsh J,Ginsberg JS,Chan N,Guyatt G,Eikelboom JW

更新日期：2014-01-01 00:00:00

abstract：:Factor X (FX) is a vitamin K-dependent serine protease zymogen that functions in both the extrinsic and intrinsic pathways of blood coagulation. In this study, the 5'-flanking region of the murine FX gene was analyzed to determine those elements that govern its transcriptional activity and regulation. Consistent with ...

journal_title：Thrombosis and haemostasis

authors： Wilberding JA,Castellino FJ

更新日期：2000-12-01 00:00:00

abstract：:alpha-Granule protein storage is important for producing platelets with normal haemostatic function. The low to undetectable levels of several megakaryocyte-synthesized alpha-granule proteins in normal plasma suggest megakaryocytes are important to sequester these proteins in vivo. alpha-Granule protein storage in vit...

journal_title：Thrombosis and haemostasis

authors： Veljkovic DK,Cramer EM,Alimardani G,Fichelson S,Massé JM,Hayward CP

更新日期：2003-11-01 00:00:00

abstract：:Venous oxygen tension (pO2) was measured in discrete samples of blood obtained through the femoral vein of cardiac catheterisation patients before, during and after application of sustained external graduated pressure in the form of compression stockings (T. E. D. Kendall). There was a significant reduction (p less th...

journal_title：Thrombosis and haemostasis

authors： Okoye GC,Evans JH,Beattie J,Lowe GD,Lorimer AR,Forbes CD

更新日期：1984-02-28 00:00:00

abstract：:Human fibrinogen was subjected to limited proteolytic attack by thrombin, batroxobin or Agkistrodon contortrix thrombin-like enzyme, yielding desAB-, desA- or desB-fibrin monomers, respectively. Turbidity curves demonstrated that, with all three enzymes, the polymerization process was strongly accelerated by increasin...

journal_title：Thrombosis and haemostasis

authors： Furlan M,Rupp C,Beck EA,Svendsen L

更新日期：1982-04-30 00:00:00

abstract：:The pathogenesis of abdominal aortic aneurysm (AAA) involves a central component of chronic inflammation which is predominantly mediated by myeloid cells. We hypothesized that the local inflammatory activity may be reflected in systemic alterations of neutrophil and monocyte populations as well as in soluble factors o...

journal_title：Thrombosis and haemostasis

authors： Zagrapan B,Eilenberg W,Prausmueller S,Nawrozi P,Muench K,Hetzer S,Elleder V,Rajic R,Juster F,Martelanz L,Hayden H,Klopf J,Inan C,Teubenbacher P,Weigl MP,Kirchweger P,Beitzke D,Jilma B,Wojta J,Bailey MA,Scott DJA,

更新日期：2019-05-01 00:00:00

abstract：:Peripheral vascular disease (PVD) is an indicator of diffuse atherosclerosis and is associated with a greatly increased incidence of coronary heart and cerebrovascular disease. Although several studies have assessed whether in vivo platelet activation takes place in patients with PVD, no data are available comparing d...

journal_title：Thrombosis and haemostasis

authors： Gresele P,Catalano M,Giammarresi C,Volpato R,Termini R,Ciabattoni G,Nenci GG,Davì G

更新日期：1997-12-01 00:00:00

abstract：:Despite great efforts in stroke research, disability and recurrence rates in ischaemic stroke remain unacceptably high. To address this issue, one potential target for novel therapeutics is the glycoprotein von Willebrand factor (vWF), which increases in thrombogenicity especially under high shear rates as it bridges ...

journal_title：Thrombosis and haemostasis

authors： Buchtele N,Schwameis M,Gilbert JC,Schörgenhofer C,Jilma B

更新日期：2018-06-01 00:00:00

abstract：:Recent investigations have revealed the crucial role of von Willebrand factor (vWF) in platelet thrombus formation under flow conditions. The plasma concentrations of vWF were measured together with various hemodynamic and hemostatic parameters in 51 cases of acute myocardial infarction. In 10 randomly selected cases,...

journal_title：Thrombosis and haemostasis

authors： Sakai H,Goto S,Kim JY,Aoki N,Abe S,Ichikawa N,Yoshida M,Nagaoka Y,Handa S

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND: Accurate diagnosis of symptomatic low von Willebrand factor (VWF) remains a major challenge in von Willebrand disease (VWD). However, present tests do not adequately take into account flow forces that, at very high shear rates, reveal a weakness in the VWF-platelet glycoprotein glycoprotein Ib bond in norma...

journal_title：Thrombosis and haemostasis

authors： Grabowski EF,Van Cott EM,Bornikova L,Boyle DC,Silva RL

更新日期：2020-05-01 00:00:00

abstract：:Isolated rat hepatocytes possess per cell 4,500 high-affinity binding sites for thrombin with a Kd of 30-40 pM, and 2.8 X 10(5) low-affinity sites with a Kd of 30 nM. These binding sites are highly specific for thrombin. Half-maximal binding of 125I-labelled thrombin is achieved after 3 min at 37 degrees C and 7 min a...

journal_title：Thrombosis and haemostasis

authors： Weyer B,Petersen TE,Sonne O

更新日期：1988-12-22 00:00:00

abstract：:Five expert laboratories have participated in a cross-laboratory study to co-evaluate and compare three commercial Factor VIII/von Willebrand factor (VWF) concentrates. A total of nine factor concentrate lots were evaluated, comprising AHF (High Purity) (AHF HP; x3), Biostate (x3) and Humate/Haemate (x3). All laborato...

journal_title：Thrombosis and haemostasis

authors： Favaloro EJ,Bukuya M,Martinelli T,Tzouroutis J,Duncan E,Welldon K,Collecutt M,Aumann H,Thom J,Gilmore G

更新日期：2002-03-01 00:00:00

abstract：:Carboxypeptidase U (CPU, CPB2, TAFIa) is a basic carboxypeptidase that is able to attenuate fibrinolysis. The inactive precursor procarboxypeptidase U is converted to its active form by thrombin, the thrombin-thrombomodulin complex or plasmin. The aim of this study was to investigate and characterise the time course o...

journal_title：Thrombosis and haemostasis

authors： Leenaerts D,Aernouts J,Van Der Veken P,Sim Y,Lambeir AM,Hendriks D

更新日期：2017-07-26 00:00:00

abstract：:Accurate and precise measurement of plasma D-dimer levels is important in the diagnosis and management of venous thromboembolism. Considerable variability in D-dimer results obtained using different methods has, however, been reported in multicentre studies. This study explored in two separate multicentre exercises th...

journal_title：Thrombosis and haemostasis

authors： Jennings I,Woods TA,Kitchen DP,Kitchen S,Walker ID

更新日期：2007-11-01 00:00:00

abstract：:Interactions between endothelial cell adhesion molecules and their beta2 integrin adhesive receptors on leukocytes are thought to play a role in the pathogenesis of inflammatory diseases and probably vasculitis. We describe a case in whom leukocytoclastic vasculitis was associated to a monoclonal immunoglobulin G2 kap...

journal_title：Thrombosis and haemostasis

authors： Dupuy E,Herbert JM,Giraudeau V,Quere I,Zini JM,Tobelem G

更新日期：1998-09-01 00:00:00

abstract：:The primary goal of this study was to develop a method for evaluating fibrin-specific antibodies as thrombus detecting agents. The apparatus and assay conditions were chosen by testing antibody 64C5, which binds to the amino terminus of the fibrin beta chain, for its ability to bind to human blood clots. Using 125I-la...

journal_title：Thrombosis and haemostasis

authors： Liau CS,Haber E,Matsueda GR

更新日期：1987-02-03 00:00:00

abstract：:Phospholipase C (PLC)-β2 (gene PLCB2) is a critical regulator of platelet responses upon activation. Mechanisms regulating of PLC-β2 expression in platelets/MKs are unknown. Our studies in a patient with platelet PLC-β2 deficiency revealed the PLCB2 coding sequence to be normal and decreased platelet PLC-β2 mRNA, sugg...

journal_title：Thrombosis and haemostasis

authors： Mao G,Jin J,Kunapuli SP,Rao AK

更新日期：2016-10-28 00:00:00

abstract：:Early treatment of disseminated intravascular coagulation (DIC) is recommended but global coagulation tests used in authorized DIC criteria are not sensitive for diagnosis of early-phase DIC. We examined the plasma levels of thrombin-antithrombin complex (TAT), plasmin-plasmin inhibitor complex (PPIC) and D-dimer in p...

journal_title：Thrombosis and haemostasis

authors： Asakura H,Wada H,Okamoto K,Iba T,Uchiyama T,Eguchi Y,Kawasugi K,Koga S,Mayumi T,Koike K,Gando S

更新日期：2006-02-01 00:00:00

abstract：:We previously reported a monoclonal antibody named IF-43 that specifically recognizes thrombin-modified fibrinogen (desAA- and desAABB- fibrin monomer) bound with fibrinogen or other D(1) domain-containing plasmic fragments such as fragments X,Y, and D(1), but not intact fibrinogen or cross-linked fibrin degradation p...

journal_title：Thrombosis and haemostasis

authors： Nakahara K,Kazahaya Y,Shintani Y,Yamazumi K,Eguchi Y,Koga S,Wada H,Matsuda M

更新日期：2003-05-01 00:00:00

abstract：:The still living members of the original bleeder family on the Aland Islands described by von Willebrand in 1926 have been reinvestigated by using modern laboratory techniques for the measurement of the Factor VIII complex and with regard to platelet aggregation. The low level of F VIII : C activity demonstrated in 19...

journal_title：Thrombosis and haemostasis

authors： Nyman D,Eriksson AW,Blombäck M,Frants RR,Wahlberg P

更新日期：1981-02-23 00:00:00

abstract：:Asymmetric dimethylarginine (ADMA), myeloperoxidase (MPO) and paraoxonase 1 (PON1) are directly involved in the pathogenesis of atherosclerosis by modulation of oxidative stress and/or NO bioavailability. We aimed to assess whether endurance exercise which is known to be cardioprotective could beneficially affect thes...

journal_title：Thrombosis and haemostasis

authors： Richter B,Niessner A,Penka M,Grdić M,Steiner S,Strasser B,Ziegler S,Zorn G,Maurer G,Simeon-Rudolf V,Wojta J,Huber K

更新日期：2005-12-01 00:00:00