Enhancement of spontaneous fibrinolytic activity in diabetic retinopathy.

abstract：:Tissue factor (TF) is the blood coagulation initiator, whose cofactor function is required for physiological factor VIIa (FVIIa)-mediated activation of factor X (FX) to FXa. A previous study reported TF on herpes simplex virus type 1 (HSV1), but this explained only part of FVIIa-dependent FXa generation observed on th...

journal_title：Thrombosis and haemostasis

authors： Sutherland MR,Friedman HM,Pryzdial EL

更新日期：2004-11-01 00:00:00

abstract：:The recombinant plasminogen activator BM 06.022 consists of the kringle 2 and the protease domains of human t-PA and is unglycosylated because of the expression in Escherichia coli. The thrombolytic and pharmacokinetic properties as well as the hemostasis effects of BM 06.022 were investigated in the rabbit model of j...

journal_title：Thrombosis and haemostasis

authors： Martin U,Fischer S,Kohnert U,Opitz U,Rudolph R,Sponer G,Stern A,Strein K

更新日期：1991-05-06 00:00:00

abstract：:Subcutaneous heparin is the treatment of choice for women requiring anticoagulant therapy during pregnancy. However, heparin therapy presents a management problem at delivery because of its potential to cause a persistent anticoagulant effect and thus increase the risk of bleeding. In order to avoid therapeutic compli...

journal_title：Thrombosis and haemostasis

authors： Anderson DR,Ginsberg JS,Burrows R,Brill-Edwards P

更新日期：1991-03-04 00:00:00

abstract：:Clotting factor VIII (fVIII)-inhibitory antibodies represent a major problem in the treatment of haemophilia A. To understand the inactivation mechanisms and to pave the way towards modifications of recombinant clotting factors that reduce their immunogenicity, the exact localization of immunodominant epitopes is requ...

journal_title：Thrombosis and haemostasis

authors： Mühle C,Schulz-Drost S,Khrenov AV,Saenko EL,Klinge J,Schneider H

更新日期：2004-03-01 00:00:00

abstract：:In the present research protein analysis on SDS-polyacrylamide gel electrophoresis (PAGE) has been used to study the glycoprotein pattern of the blood platelets of four members from a family affected by May-Hegglin anomaly. In order to characterize the glycoprotein fractions, lactoperoxidase-iodination and immunopreci...

journal_title：Thrombosis and haemostasis

authors： Ricci G,Manservigi R,Albonici L,Zavagli G,Cassai E

更新日期：1985-12-17 00:00:00

abstract：:This review collects evidence about immune and inflammatory functions of platelets from a clinician's point of view. A focus on clinically relevant immune functions aims at stimulating further research, because the complexity of platelet immunity is incompletely understood and not yet translated into patient care. Pla...

journal_title：Thrombosis and haemostasis

authors： Duerschmied D,Bode C,Ahrens I

更新日期：2014-10-01 00:00:00

abstract：:Fibrin(ogen) is the major matrix ligand for beta3 integrins. If alpha(v)beta3 is the major receptor for fibrin(ogen) on intimal smooth muscle cells, we might expect to see this integrin associated with fibrin(ogen). Eighty-four specimens obtained from endarterectomies of 14 patients were studied. Fibrin was frequently...

journal_title：Thrombosis and haemostasis

authors： Ikari Y,Yee KO,Hatsukami TS,Schwartz SM

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:Infusions of apolipoprotein A-I (apoA-I), the major protein component of high-density lipoproteins (HDL), result in aortic valve stenosis (AVS) regression in experimental models. Severe AVS can be complicated by acquired von Willebrand syndrome, a haemorrhagic disorder associated with loss of high-molecular-...

journal_title：Thrombosis and haemostasis

authors： Gebhard C,Maafi F,Stähli BE,Bonnefoy A,Gebhard CE,Nachar W,de Oliveira Moraes AB,Mecteau M,Mihalache-Avram T,Lavoie V,Kernaleguen AE,Shi Y,Busseuil D,Chabot-Blanchet M,Perrault LP,Rhainds D,Rhéaume E,Tardif JC

更新日期：2018-02-01 00:00:00

abstract：:The effects of G4120, a cyclic Arg-Gly-Asp (RGD) containing peptide which inhibits fibrinogen binding to the platelet receptor GPIIb/IIIa, on thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) were investigated in a combined arterial and venous thrombosis model in heparinized dogs. The arterial th...

journal_title：Thrombosis and haemostasis

authors： Lu HR,Gold HK,Wu Z,Yasuda T,Pauwels P,Rapold HJ,Napier M,Bunting S,Collen D

更新日期：1992-06-01 00:00:00

abstract：:The behavior of direct fibrinolytic (non-plasmin) proteinase activity and plasminogen-activator activity in the lung and spleen was investigated in rats after a single intravenous injection of bacterial endotoxin, and the influence of thrombin inhibitors on the effects of the endotoxin was assessed. The non-plasmin fi...

journal_title：Thrombosis and haemostasis

authors： Okamoto U,Nagamatsu Y,Horie N,Yamamoto J,Sasaki K

更新日期：1985-06-24 00:00:00

abstract：:Recent investigations have revealed the crucial role of von Willebrand factor (vWF) in platelet thrombus formation under flow conditions. The plasma concentrations of vWF were measured together with various hemodynamic and hemostatic parameters in 51 cases of acute myocardial infarction. In 10 randomly selected cases,...

journal_title：Thrombosis and haemostasis

authors： Sakai H,Goto S,Kim JY,Aoki N,Abe S,Ichikawa N,Yoshida M,Nagaoka Y,Handa S

更新日期：2000-08-01 00:00:00

abstract：:Myocardial infarction results from a platelet-rich occlusive coronary thrombus. Platelet membrane glycoprotein IIb/IIIa plays an important role in platelet adhesion and aggregation. Two polymorphisms of the gene encoding the IIIa subunit. PLA1 and PLA2, have been identified. We investigated the frequency of these poly...

journal_title：Thrombosis and haemostasis

authors： Durante-Mangoni E,Davies GJ,Ahmed N,Ruggiero G,Tuddenham EG

更新日期：1998-08-01 00:00:00

abstract：:Ultra-low-molecular-weight heparins (ULMWHs) with better efficacy and safety ratios are under development; however, there are few structural data available. The main structural features and molecular weight of ULMWHs were studied and compared to enoxaparin. Their monosaccharide composition and average molecular weight...

journal_title：Thrombosis and haemostasis

authors： Lima MA,Viskov C,Herman F,Gray AL,de Farias EH,Cavalheiro RP,Sassaki GL,Hoppensteadt D,Fareed J,Nader HB

更新日期：2013-03-01 00:00:00

abstract：:The technique of crossed immunoelectrophoresis has been used to study the binding to purified antithrombin III (At III) of heparin and other mucopolysaccharides. The technique was unable to detect differences among samples of whole heparin from various manufacturers, but proved useful in studying the binding of hepari...

journal_title：Thrombosis and haemostasis

authors： Barrowcliffe TW

更新日期：1980-02-29 00:00:00

abstract：:Heparin is often used as an adjunct to thrombolytic therapy in order to prevent reocclusion of the patent vessels in patients with thrombotic disease. Controversy exists as to whether heparin is required for effective clot lysis with tissue-type plasminogen activator, while in vitro data and small scale clinical trial...

journal_title：Thrombosis and haemostasis

authors： Burke SE,Lubbers NL,Nelson RA,Henkin J

更新日期：1993-04-01 00:00:00

abstract：:Plasminogen activator inhibitor type-1 (PAI-1) is a physiologic modulator of the fibrinolytic system. We have shown previously that PAI-1 biosynthesis in cultured cells depends on several factors in serum. Because platelets are richly endowed with specific growth factors and because the release reaction is an integral...

journal_title：Thrombosis and haemostasis

authors： Hopkins WE,Westerhausen DR,Fujii S,Billadello JJ,Sobel BE

更新日期：1991-08-01 00:00:00

abstract：:Fucoïdans catalyse thrombin inhibition by antithrombin (AT) and heparin cofactor II (HCII); their affinity for each serpin varies according to the seaweed species from which they are extracted, as well as their chemical composition and molecular weight. We extracted a homogeneous fucoïdan fraction from Ascophyllum nod...

journal_title：Thrombosis and haemostasis

authors： Mauray S,Sternberg C,Theveniaux J,Millet J,Sinquin C,Tapon-Bretaudière J,Fischer AM

更新日期：1995-11-01 00:00:00

abstract：:Thrombin incubated with 2,3-diphosphoglycerate (150 nmol 2,3-DPG/1 NIH thrombin unit) lost up to 70% of its clotting activity, whereas the esterase activity remained unchanged. No fibrinopeptide release by thrombin was observed in the presence of 2,3-DPG. The fibrin polymerization was normal. By chromatography on Ambe...

journal_title：Thrombosis and haemostasis

authors： Del Principe D,Strappini PM,Del Vecchio S,Menichelli A,Biancini G,Cosmi EV,Bastianon V,D'Arcangelo C

更新日期：1981-10-01 00:00:00

abstract：:In patients with von Willebrand disease (VWD) replacement therapy with factor VIII/von Willebrand (VWF) concentrates is increasingly applied as prophylactic regimen. Since 2000, 82 consecutively enrolled patients with clinically relevant bleeding episodes (spontaneous, peri- or postoperative) were diagnosed with VWD [...

journal_title：Thrombosis and haemostasis

authors： Halimeh S,Krümpel A,Rott H,Bogdanova N,Budde U,Manner D,Faeser B,Mesters R,Nowak-Göttl U

更新日期：2011-04-01 00:00:00

abstract：:Increased plasma plasminogen activator inhibitor-1 (PAI-1) has been implicated in the development of vascular disease. In type 2 diabetes mellitus high PAI-1 levels are associated with increased plasma concentrations of free fatty acids (FFA) and triacylglycerol indicating an association or a causal relationship. To a...

journal_title：Thrombosis and haemostasis

authors： Krebs M,Geiger M,Polak K,Vales A,Schmetterer L,Wagner OF,Waldhäusl W,Binder BR,Roden M

更新日期：2003-09-01 00:00:00

abstract：:Serine proteases are proteolytic enzymes with an active serine residue in their catalytic site. Kallikreins are a subgroup of the serine protease family and are known to have diverse physiological functions. The human tissue kallikrein gene family has now been fully characterized and includes 15 members, clustered in ...

journal_title：Thrombosis and haemostasis

authors： Yousef GM,Diamandis EP

更新日期：2003-07-01 00:00:00

abstract：:Hyperhomocysteinemia is a risk factor of venous thromboembolism. The risk of recurrence in patients with hyperhomocysteinemia is unknown, and the optimal therapy for these patients after acute venous thromboembolism is uncertain. In a multicenter study, 264 patients with an objectively documented single episode of idi...

journal_title：Thrombosis and haemostasis

authors： Eichinger S,Stümpflen A,Hirschl M,Bialonczyk C,Herkner K,Stain M,Schneider B,Pabinger I,Lechner K,Kyrle PA

更新日期：1998-10-01 00:00:00

abstract：:Treatment of bleeding in patients with Glanzmann's thrombasthenia (GT) can be hampered by iso-antibodies against the αIIbβ3 integrin, which cause rapid clearance of transfused donor platelets. Type 1 GT patients with a total absence of αIIbβ3 from the platelet surface are known to be susceptible to form such isoantibo...

journal_title：Thrombosis and haemostasis

authors： Wihadmadyatami H,Röder L,Berghöfer H,Bein G,Heidinger K,Sachs UJ,Santoso S

更新日期：2016-08-01 00:00:00

abstract：:Elucidation of the molecular defects responsible for antithrombin III deficiency is proceeding rapidly. In order that a record is kept of the new and duplicated mutations that are found, we have compiled a database that we plan to update annually. In this, the first report of the database, we list 6 antithrombin III l...

journal_title：Thrombosis and haemostasis

authors： Lane DA,Ireland H,Olds RJ,Thein SL,Perry DJ,Aiach M

更新日期：1991-12-02 00:00:00

abstract：:An association has been reported between thrombotic events and the use of L-asparaginase (ASP) in children with acute lymphoblastic leukaemia (ALL). The mechanism for thrombosis is likely related to an acquired antithrombin deficiency. Since a primary prophylaxis using antithrombin concentrates may prevent thrombosis,...

journal_title：Thrombosis and haemostasis

authors： Mitchell L,Andrew M,Hanna K,Abshire T,Halton J,Wu J,Anderson R,Cherrick I,Desai S,Mahoney D,McCusker P,Chait P,Abdolell M,de Veber G,Mikulis D

更新日期：2003-08-01 00:00:00

abstract：:Ridogrel (6.3 x 10(-6) to 10(-4) M) inhibited contractions of isolated rat caudal arteries and rabbit femoral arteries caused by U-46619. The slope of an Arunlakshana-Schild plot (pA2-value: 3.4 x 10(-6) M) on the caudal artery was slightly higher than one (1.14). This effect was maximal within 20 min of incubation of...

journal_title：Thrombosis and haemostasis

authors： Janssens WJ,Cools FJ,Hoskens LA,Van Nueten JM

更新日期：1990-08-13 00:00:00

abstract：:Vasopressin infusions in normal volunteers that produce concentrations in plasma comparable to those seen during stress, cause an increase in plasma factor VIII and shortening of the euglobulin clot lysis time (ECLT). We have investigated the relationship between endogenous vasopressin (aVP) release and haemostatic fu...

journal_title：Thrombosis and haemostasis

authors： Grant PJ,Tate GM,Davies JA,Williams NS,Prentice CR

更新日期：1986-02-28 00:00:00

abstract：:The clinical severity in some patients with haemophilia A appears to be unrelated to the levels of factor (F)VIII activity (FVIII:C), but mechanisms are poorly understood. We have investigated a patient with a FVIII gene mutation at Arg1781 to His (R1781H) presenting with a mild phenotype despite FVIII:C of 0.9 IU/dl....

journal_title：Thrombosis and haemostasis

authors： Yada K,Nogami K,Wakabayashi H,Fay PJ,Shima M

更新日期：2013-06-01 00:00:00

abstract：:Evaluation of factor F(V)III replacement in patients with haemophilia A undergoing surgery is critical for FVIII concentrates, yet large scale, multi-center prospective studies, particularly using continuous infusion, are generally lacking for new products. This study evaluated efficacy and safety of a newly developed...

journal_title：Thrombosis and haemostasis

authors： Négrier C,Shapiro A,Berntorp E,Pabinger I,Tarantino M,Retzios A,Schroth P,Ewenstein B

更新日期：2008-08-01 00:00:00

abstract：:Fibrinogen Matsumoto V (M-V) is a dysfibrinogen identified in a 52-year-old woman with systemic lupus erythematous. The triplet AGG encoding the amino acid residue Aalpha19 was replaced by GGG, resulting in the substitution of Arg-->Gly. Residue Aalpha19 has been shown to be one of the most important amino acids in th...

journal_title：Thrombosis and haemostasis

authors： Tanaka H,Terasawa F,Ito T,Tokunaga S,Ishida F,Kitano K,Kiyosawa K,Okumura N

更新日期：2001-01-01 00:00:00