Associations between children's family environment, spontaneous brain oscillations, and emotional and behavioral problems.

Abstract:

:The family environment in childhood has a strong effect on mental health outcomes throughout life. This effect is thought to depend at least in part on modifications of neurodevelopment trajectories. In this exploratory study, we sought to investigate whether a feasible resting-state fMRI metric of local spontaneous oscillatory neural activity, the fractional amplitude of low-frequency fluctuations (fALFF), is associated with the levels of children's family coherence and conflict. Moreover, we sought to further explore whether spontaneous activity in the brain areas influenced by family environment would also be associated with a mental health outcome, namely the incidence of behavioral and emotional problems. Resting-state fMRI data from 655 children and adolescents (6-15 years old) were examined. The quality of the family environment was found to be positively correlated with fALFF in the left temporal pole and negatively correlated with fALFF in the right orbitofrontal cortex. Remarkably, increased fALFF in the temporal pole was associated with a lower incidence of behavioral and emotional problems, whereas increased fALFF in the orbitofrontal cortex was correlated with a higher incidence.

authors

Sato JR,Biazoli CE Jr,Salum GA,Gadelha A,Crossley N,Vieira G,Zugman A,Picon FA,Pan PM,Hoexter MQ,Amaro E Jr,Anés M,Moura LM,Del'Aquilla MAG,Mcguire P,Rohde LA,Miguel EC,Bressan RA,Jackowski AP

doi

10.1007/s00787-018-1240-y

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

835-845

issue

6

eissn

1018-8827

issn

1435-165X

pii

10.1007/s00787-018-1240-y

journal_volume

28

pub_type

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