Comparative efficacy of once-a-day extended-release methylphenidate, two-times-daily immediate-release methylphenidate, and placebo in a laboratory school setting.

Abstract:

BACKGROUND:Given the dosing limitations of methylphenidate short-acting preparations in treating ADHD, galenics with longer release of the substance were developed mainly to avoid drug intake during school hours. OBJECTIVES:This investigation was conducted to assess the efficacy and the duration of action of a new extended-release formulation of methylphenidate (Medikinet retard) as a once-daily treatment for children with attention-deficit hyperactivity disorder (ADHD). METHOD:This was a randomized, double-blind, crossover multicentre study with three treatment conditions: once-daily extended-release methylphenidate, twice-daily immediate-release methylphenidate and placebo given to 79 children (8-14 years old) with ADHD. Daily assessments in an analogue classroom setting included blind ratings of attention and deportment and a performance measure (math test) obtained 5 times over an 8-hour period. Secondary measures included an ADHD rating scale, based on DSMIV/ ICD-10 separately rated for the morning and the afternoon. RESULTS:Both active treatment conditions displayed significant time course effects and were superior to placebo in improving all efficacy measures. Once a day extended-release methylphenidate was not different from the same dose of twice daily immediate-release methylphenidate. CONCLUSIONS:These data provide support for the benefit of this novel, once-daily methylphenidate preparation in the treatment of ADHD. The longer duration of action of Medikinet Retard has the potential to simplify psychostimulant treatment, thus reducing dose diversion and eliminating the need for in-school administration.

authors

Döpfner M,Gerber WD,Banaschewski T,Breuer D,Freisleder FJ,Gerber-von Müller G,Günter M,Hässler F,Ose C,Rothenberger A,Schmeck K,Sinzig J,Stadler C,Uebel H,Lehmkuhl G

doi

10.1007/s00787-004-1009-3

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

I93-101

eissn

1018-8827

issn

1435-165X

journal_volume

13 Suppl 1

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Longitudinal outcomes of children with pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS).

    abstract::Little is known about the natural history of children with pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS). This study prospectively followed 33 children with PANDAS for up to 4.8 years (mean 3.3 ± 0.7 years) after enrollment in a 24-week randomized, double-blind, place...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00787-017-1077-9

    authors: Leon J,Hommer R,Grant P,Farmer C,D'Souza P,Kessler R,Williams K,Leckman JF,Swedo S

    更新日期:2018-05-01 00:00:00

  • Task-related motivation and academic achievement in children and adolescents with ADHD.

    abstract::Academic impairment in individuals with attention-deficit/hyperactivity disorder (ADHD) is in part due to reduced motivation for academic tasks, which is likely to vary as a function of task characteristics. The current study employed a new questionnaire-the Child and Adolescent Motivational Profile (CHAMP)-to examine...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-020-01494-8

    authors: Morsink S,Sonuga-Barke E,Van der Oord S,Van Dessel J,Lemiere J,Danckaerts M

    更新日期:2020-03-10 00:00:00

  • Child mental health and resilience in the context of socioeconomic disadvantage: results from the Born in Bradford cohort study.

    abstract::Socioeconomic disadvantage has been linked to mental health difficulties in children and adolescents, although many children appear to do well despite exposure to financial adversity in childhood. Our study looked at the effects of family financial difficulty on children's mental health outcomes (n = 636) at 4-5 years...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00787-019-01348-y

    authors: Kirby N,Wright B,Allgar V

    更新日期:2020-04-01 00:00:00

  • Multi-rater developmental trajectories of hyperactivity-impulsivity and inattention symptoms from 1.5 to 17 years: a population-based birth cohort study.

    abstract::The developmental course of hyperactivity-impulsivity and inattention symptoms from infancy to adolescence has not been documented in a population sample. The aim of this study was to describe the developmental course of hyperactivity-impulsivity and inattention symptoms from 1.5 to 17 years using multiple informants,...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-018-1258-1

    authors: Vergunst F,Tremblay RE,Galera C,Nagin D,Vitaro F,Boivin M,Côté SM

    更新日期:2019-07-01 00:00:00

  • Is social anxiety disorder in childhood associated with developmental deficit/delay?

    abstract::Children with social anxiety disorder (SAD) have been reported to display reduced social skills. Less attention has been paid to whether neurodevelopmental deficits/delays (NDD's) in language and motor function may contribute to their impaired social skills. The present study aimed to assess the extent of language and...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-007-0642-z

    authors: Kristensen H,Torgersen S

    更新日期:2008-03-01 00:00:00

  • Factors affecting nightmares in children: parents' vs. children's ratings.

    abstract:OBJECTIVE:The present study investigated the relationship between daytime symptomatology and nightmare frequency in school-aged children by eliciting daytime symptoms and nightmare frequency from children directly in addition to questionnaires completed by their parents. METHODS:A sample of 4,834 parents and 4,531 of ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-008-0697-5

    authors: Schredl M,Fricke-Oerkermann L,Mitschke A,Wiater A,Lehmkuhl G

    更新日期:2009-01-01 00:00:00

  • Non-stimulant treatments for ADHD.

    abstract::We reviewed the literature of medication trials in ADHD to evaluate the scope of the available non-stimulant treatments. A variety of compounds with a common noradrenergic/ dopaminergic activity have shown documented anti-ADHD activity. There is a substantial body of literature documenting the efficacy of tricyclic an...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章,评审

    doi:10.1007/s007870070019

    authors: Biederman J,Spencer T

    更新日期:2000-01-01 00:00:00

  • Changes in serum levels of kynurenine metabolites in paediatric patients affected by ADHD.

    abstract::This study aims at determining serum levels of tryptophan and other metabolites of the kynurenine pathway in children with attention deficit hyperactivity disorder (ADHD) compared to healthy controls. Such metabolites interact with glutamate receptors in the central nervous system, potentially modulating mechanisms th...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-017-1002-2

    authors: Evangelisti M,De Rossi P,Rabasco J,Donfrancesco R,Lionetto L,Capi M,Sani G,Simmaco M,Nicoletti F,Villa MP

    更新日期:2017-12-01 00:00:00

  • Psychosocial problems among immigrant and non-immigrant children--ethnicity plays a role in their occurrence and identification.

    abstract:BACKGROUND:This study aims to examine a) the prevalence of psychosocial problems and b) the association between parent-reported problems and the identification by doctors and nurses (child health professionals, CHP) working in preventive child health care, among immigrant and non-immigrant children. METHODS:CHPs exami...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-005-0454-y

    authors: Reijneveld SA,Harland P,Brugman E,Verhulst FC,Verloove-Vanhorick SP

    更新日期:2005-05-01 00:00:00

  • Maternal depression symptoms and internalising problems in the offspring: the role of maternal and family factors.

    abstract::Maternal depression symptoms (MDS) are a robust risk factor for internalising problems (IP) in the offspring. However, the relative importance of MDS and other factors associated with it (i.e. other types of maternal psychopathology, maternal parenting practices, family characteristics) is not well understood. To (a) ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-017-1096-6

    authors: Ahun MN,Consoli A,Pingault JB,Falissard B,Battaglia M,Boivin M,Tremblay RE,Côté SM

    更新日期:2018-07-01 00:00:00

  • Formal thought disorder in autism spectrum disorder predicts future symptom severity, but not psychosis prodrome.

    abstract::Formal thought disorder (FTD) is a disruption in the flow of thought, which is inferred from disorganisation of spoken language. FTD in autism spectrum disorders (ASD) might be a precursor of psychotic disorders or a manifestation of ASD symptom severity. The current longitudinal study is a seven-year follow-up of 91 ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-014-0552-9

    authors: Eussen ML,de Bruin EI,Van Gool AR,Louwerse A,van der Ende J,Verheij F,Verhulst FC,Greaves-Lord K

    更新日期:2015-02-01 00:00:00

  • Mental and behavioural outcome of inter-ethnic adoptees: a review of the literature.

    abstract::Selective examples from the literature on interethnic adoption are reviewed focusing on the various factors influencing adoption results. Late age at adoption, neglect and institutionalisation are risk factors for the psychological and behavioural problems in adoptees and families. The review also analyses methodologi...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章,评审

    doi:10.1007/s00787-004-0358-2

    authors: Fensbo C

    更新日期:2004-04-01 00:00:00

  • Influence of coping strategies on the efficacy of YAM (Youth Aware of Mental Health): a universal school-based suicide preventive program.

    abstract::The school-based mental health promotion and suicide prevention universal program Youth Aware of Mental Health (YAM) significantly reduces incident suicide attempts and severe suicidal ideation. This paper aims at elucidating psychological mechanisms underlying YAM's efficacy. Our hypothesis is that YAM operates throu...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-020-01476-w

    authors: Kahn JP,Cohen RF,Tubiana A,Legrand K,Wasserman C,Carli V,Apter A,Balazs J,Banzer R,Baralla F,Barzilai S,Bobes J,Brunner R,Corcoran P,Cosman D,Guillemin F,Haring C,Kaess M,Bitenc UM,Mészàros G,McMahon E,Postuvan

    更新日期:2020-12-01 00:00:00

  • Psychometric properties of two ADHD questionnaires: comparing the Conners' scale and the FBB-HKS in the general population of German children and adolescents--results of the BELLA study.

    abstract:BACKGROUND AND OBJECTIVE:To examine and compare the psychometric properties of two short screening instruments for children and adolescents suffering from attention deficit-/ hyperactivity disorder (ADHD). The Conners' Hyperactivity Index consists of ten items that assess symptoms of hyperactivity through self-report a...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-008-1012-1

    authors: Erhart M,Döpfner M,Ravens-Sieberer U,BELLA study group.

    更新日期:2008-12-01 00:00:00

  • Does ADHD moderate the manifestation of anxiety disorders in children?

    abstract::The main aim of this study was to examine the moderating effects of attention deficit hyperactivity disorder (ADHD) on anxiety disorders in children. Data were analyzed from a large referred sample of children with anxiety disorder without comorbid ADHD (anxiety disorder, N = 253), anxiety disorder plus comorbid ADHD ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-009-0041-8

    authors: Hammerness P,Geller D,Petty C,Lamb A,Bristol E,Biederman J

    更新日期:2010-02-01 00:00:00

  • The script model in relation to autism.

    abstract::The primary purpose of this study was to investigate autistic children's scripts for social routines. Scripts specify familiar events in terms of who does what, when, to whom, and why. Scripts are verbalizations of mental event representations, containing and organizing generalized knowledge of how the world works. Sc...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s007870050082

    authors: Trillingsgaard A

    更新日期:1999-03-01 00:00:00

  • Are there specific disabilities of number processing in adolescent patients with Anorexia nervosa? Evidence from clinical and neuropsychological data when compared to morphometric measures from magnetic resonance imaging.

    abstract::The cerebral effect of the loss of body weight in Anorexia nervosa (A.n.)--the so-called 'pseudoatrophy'-- is well known and confirmed by several neuroimaging studies. Another subject of intensive research has been whether A.n. leads to specific cognitive impairments, especially of intelligence. However, there are no ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s007870070005

    authors: Neumärker KJ,Bzufka WM,Dudeck U,Hein J,Neumärker U

    更新日期:2000-01-01 00:00:00

  • Using a genetically informative design to examine the relationship between breastfeeding and childhood conduct problems.

    abstract::A number of public health interventions aimed at increasing the uptake of breastfeeding are in place in the United States and other Western countries. While the physical health and nutritional benefits of breastfeeding for the mother and child are relatively well established, the evidence for psychological effects is ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00787-011-0224-y

    authors: Shelton KH,Collishaw S,Rice FJ,Harold GT,Thapar A

    更新日期:2011-12-01 00:00:00

  • Autistic spectrum disorders in childhood epilepsy surgery candidates.

    abstract::One third of children with autistic spectrum disorders (or pervasive developmental disorders) enter that state by regression from a more normal prior development at the onset of epilepsy or epileptiform abnormality in the electroencephalogram. In a very small proportion structural lesions of the temporal lobes are dis...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s007870050128

    authors: Taylor DC,Neville BG,Cross JH

    更新日期:1999-09-01 00:00:00

  • Not EEG abnormalities but epilepsy is associated with autistic regression and mental functioning in childhood autism.

    abstract::The aim of the study was to investigate the potential association of epilepsy and EEG abnormalities with autistic regression and mental retardation. We examined a group of 77 autistic children (61 boys, 16 girls) with an average age of 9.1 +/- 5.3 years. Clinical interview, neurological examination focused on the eval...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-004-0353-7

    authors: Hrdlicka M,Komarek V,Propper L,Kulisek R,Zumrova A,Faladova L,Havlovicova M,Sedlacek Z,Blatny M,Urbanek T

    更新日期:2004-08-01 00:00:00

  • Standard urotherapy as first-line intervention for daytime incontinence: a meta-analysis.

    abstract::According to the International Children's Continence Society (ICCS) guidelines for the treatment of daytime urinary incontinence (DUI) in children and adolescents, the first-line intervention for all types of DUI is standard urotherapy (SU). Despite this recommendation there is still no meta-analysis available on the ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00787-017-1051-6

    authors: Schäfer SK,Niemczyk J,von Gontard A,Pospeschill M,Becker N,Equit M

    更新日期:2018-08-01 00:00:00

  • Parental experiences of homeschooling during the COVID-19 pandemic: differences between seven European countries and between children with and without mental health conditions.

    abstract::The aim of the present study was to examine parental experiences of homeschooling during the COVID-19 pandemic in families with or without a child with a mental health condition across Europe. The study included 6720 parents recruited through schools, patient organizations and social media platforms (2002 parents with...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-020-01706-1

    authors: Thorell LB,Skoglund C,de la Peña AG,Baeyens D,Fuermaier ABM,Groom MJ,Mammarella IC,van der Oord S,van den Hoofdakker BJ,Luman M,de Miranda DM,Siu AFY,Steinmayr R,Idrees I,Soares LS,Sörlin M,Luque JL,Moscardino UM,Roch

    更新日期:2021-01-07 00:00:00

  • No evidence for association and linkage disequilibrium between dyslexia and markers of four dopamine-related genes.

    abstract::Dopamine genes are candidate genes for dyslexia in the light of the well-known comorbidity between dyslexia and ADHD. Within-family association and linkage disequilibrium were tested between four genetic markers at DRD4, DRD3, DRD2, and DAT loci, and dyslexia, in a sample of 130 Italian dyslexic children, 16.9% of who...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-003-0332-4

    authors: Marino C,Giorda R,Vanzin L,Molteni M,Lorusso ML,Nobile M,Baschirotto C,Alda M,Battaglia M

    更新日期:2003-08-01 00:00:00

  • Ethics of returning children's individual research findings: from principles to practice.

    abstract::Little ethical recommendations on returning children's individual research findings are available for researchers in behavioral sciences, especially when compared to genetic research. Anecdotic evidence suggests that since parents are often interested in their child's individual research findings, researchers tend to ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-020-01606-4

    authors: Vanaken GJ,Noens I,Roeyers H,van Esch L,Warreyn P,Steyaert J,Hens K

    更新日期:2020-07-26 00:00:00

  • Epidemiology of eating disorders: a two year follow up in an early adolescent school population.

    abstract:OBJECTIVE:The aims of this study were to determine the prevalence of eating disorders (ED) in a representative school population of early adolescents of both sexes and to evaluate persistence and incidence after two years. METHOD:An initial sample of 1336 (mean age = 11.37) was assessed in a two-phase design. The Chil...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-007-0625-0

    authors: Sancho C,Arija MV,Asorey O,Canals J

    更新日期:2007-12-01 00:00:00

  • Associations between attention-deficit/hyperactivity disorder and autoimmune diseases are modified by sex: a population-based cross-sectional study.

    abstract::Several studies have demonstrated associations between neuropsychiatric disorders, such as attention-deficit/hyperactivity disorder (ADHD), and the immune system, including autoimmune diseases. Since ADHD and many autoimmune diseases show sex-specific properties, such associations may also differ by sex. Using Norwegi...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-017-1056-1

    authors: Hegvik TA,Instanes JT,Haavik J,Klungsøyr K,Engeland A

    更新日期:2018-05-01 00:00:00

  • Psychosocial characteristics differentiate non-distressing and distressing voices in 10,346 adolescents.

    abstract::Adolescents hearing non-existent voices may be at risk for psychosis, but the prevalence of voice-hearing (VH) in the general population complicates clinical interpretations. Differentiating between VH with and without distress may aid treatment decisions in psychosis services, but understanding the differences betwee...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-019-01292-x

    authors: Løberg EM,Gjestad R,Posserud MB,Kompus K,Lundervold AJ

    更新日期:2019-10-01 00:00:00

  • Serum brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 levels in children with attention-deficit/hyperactivity disorder.

    abstract::It has been suggested that neurotrophins are involved in the etiopathogenesis of attention-deficit/hyperactivity disorder (ADHD). This study aimed to investigate whether there are differences in serum brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and neu...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-016-0898-2

    authors: Bilgiç A,Toker A,Işık Ü,Kılınç İ

    更新日期:2017-03-01 00:00:00

  • The combined self- and parent-rated SDQ score profile predicts care use and psychiatric diagnoses.

    abstract::The Strengths and Difficulties Questionnaire (SDQ) is widely used, based on evidence of its value for screening. This evidence primarily regards the single informant total difficulties scale and separate difficulties subscales. We assessed to what degree adolescents' SDQ profiles that combined all self- and parent-rat...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-020-01667-5

    authors: Vugteveen J,de Bildt A,Hartman CA,Reijneveld SA,Timmerman ME

    更新日期:2020-10-30 00:00:00

  • Perceptions of family relationships in adolescents with anorexia nervosa and their unaffected sisters.

    abstract::The family relationships of patients with anorexia nervosa (AN) have been extensively studied over recent years. However, using case-control designs with unrelated controls is subject to various cultural and familial biases. Studying subjective differential perceptions of family relationships in sister-pairs discordan...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-003-0319-1

    authors: Karwautz A,Nobis G,Haidvogl M,Wagner G,Hafferl-Gattermayer A,Wöber-Bingöl C,Friedrich MH

    更新日期:2003-06-01 00:00:00