Abstract:
:Twin studies described a strongly heritable component of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents. However, findings varied considerably between studies. In addition, ADHD presents with a high rate of comorbid disorders and associated psychopathology. Therefore, this literature review reports findings from population-based twin studies regarding the influence of subtypes, assessment instruments, rater effects, sex differences, and comorbidity rates on ADHD heritability estimates. In addition, genetic effects on the persistence of ADHD are discussed. By reviewing relevant factors influencing heritability estimates more homogeneous subtypes relevant for molecular genetic studies can be elicited. A systematic search of population-based twin studies in ADHD was performed, using the databases PubMed and PsycInfo. Results of family studies were added in case insufficient or contradictory findings were obtained in twin studies. Heritability estimates were strongly influenced by rater effects and assessment instruments. Inattentive and hyperactive-impulsive symptoms were likely influenced by common as well as specific genetic risk factors. Besides persistent ADHD, ADHD accompanied by symptoms of conduct or antisocial personality disorder might be another strongly genetically determined subtype, however, family environmental risk factors have also been established for this pattern of comorbidity.
journal_name
Eur Child Adolesc Psychiatryjournal_title
European child & adolescent psychiatryauthors
Freitag CM,Rohde LA,Lempp T,Romanos Mdoi
10.1007/s00787-010-0097-5subject
Has Abstractpub_date
2010-03-01 00:00:00pages
311-23issue
3eissn
1018-8827issn
1435-165Xjournal_volume
19pub_type
杂志文章,评审abstract:BACKGROUND:The process of childbirth and its complications have been related to the newborn's condition and to development at later ages. In this study, we examine how mode of delivery and delivery complications are related to the behavior and cortisol reactivity of infants during the first 2 months. METHODS:Delivery ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-007-0610-7
更新日期:2007-09-01 00:00:00
abstract::Research into Pathological Demand Avoidance (PDA), which has been suggested to be a subgroup within the Autism Spectrum Disorder (ASD), is almost nonexistent in spite of the frequent reference to the condition in clinical practice. The total population of 15 to 24-year-olds in the Faroe Islands was screened for ASD, a...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-014-0647-3
更新日期:2015-08-01 00:00:00
abstract::This study compared the neuropsychological test profiles of non-mentally retarded girls and boys consecutively referred to a neuropsychiatric clinic and those of contrast cases of girls from mainstream classrooms of one Göteborg school district. To avoid overreliance on the male prototype with regard to diagnostic cri...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s007870070041
更新日期:2000-09-01 00:00:00
abstract::Anorexia nervosa (AN) is frequently associated with symptoms of depression, anxiety, and obsessive-compulsive behavior which also develop secondary to semistarvation. It is less certain if these symptoms persist after recovery. A few studies have already reported on high prevalence rates of anxious, depressive, and ob...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-005-0431-5
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVES:To use growth mixture modelling (GMM) to identify subgroups of children with attention deficit hyperactive disorder (ADHD) who have different pharmacodynamic profiles in response to extended release methylphenidate as assessed in a laboratory classroom setting. METHODS:GMM analysis was performed on data fro...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-007-0667-3
更新日期:2008-06-01 00:00:00
abstract::Worldwide, approximately one in eight children or adolescents suffers from a mental disorder. The present study was designed to determine the self-reported prevalence of mental health problems in children aged 6-11 years across eight European countries including Italy, France, Germany, the Netherlands, Lithuania, Bulg...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-017-1073-0
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:This study aims to examine a) the prevalence of psychosocial problems and b) the association between parent-reported problems and the identification by doctors and nurses (child health professionals, CHP) working in preventive child health care, among immigrant and non-immigrant children. METHODS:CHPs exami...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-005-0454-y
更新日期:2005-05-01 00:00:00
abstract::Service comparison is a policy priority but is not without controversy. This paper aims to investigate the amount of service-level variation in outcomes in child mental health, whether it differed when examining outcomes unadjusted vs. adjusted for expected change over time, and which patient-level characteristics wer...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-016-0939-x
更新日期:2017-06-01 00:00:00
abstract::While slow processing speed (PS) is well documented in youth with ADHD, growing evidence suggests that this difficulty affects children with other neuropsychiatric conditions. Clarifying the relationship between slow PS and different forms of psychopathology is important clinically, given the potential impact of PS on...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-019-01455-w
更新日期:2020-10-01 00:00:00
abstract::The BELLA study on mental health and well-being in children and adolescents is the mental health module of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS). The cross-sectional KiGGS survey collected comprehensive data on the health status of 17,641 children and adolescents, aged...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,评审
doi:10.1007/s00787-008-1002-3
更新日期:2008-12-01 00:00:00
abstract::The impact of premorbid social and intellectual functioning in childhood and early adolescence on the developmental course of schizophrenia is not sufficiently understood. In a retrospective case study (93 consecutive in-patients, 43 males and 50 females) of first-episode psychosis occurring in adolescence, the relati...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/BF00539928
更新日期:1997-12-01 00:00:00
abstract::Information on behavior of children with Prader-Willi syndrome (PWS) and the effect of growth hormone (GH) treatment is scarce. Parents report less problem behavior during GH treatment. Forty-two pre-pubertal children, aged 3.5-14 years were studied in a randomized controlled GH trial (RCT) during 2 years, followed by...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00787-014-0662-4
更新日期:2015-09-01 00:00:00
abstract::Child and adolescent inpatient treatment has faced major changes since the year 2000, including shorter inpatient stays and a greater use of psychotropic drugs. This study explored changes and correlates of suicidal threats and suicide acts among inpatients, by comparing Finnish cross-sectional surveys from 2000 to 20...
journal_title:European child & adolescent psychiatry
pub_type: 历史文章,杂志文章
doi:10.1007/s00787-019-01286-9
更新日期:2019-09-01 00:00:00
abstract::This study aims at determining serum levels of tryptophan and other metabolites of the kynurenine pathway in children with attention deficit hyperactivity disorder (ADHD) compared to healthy controls. Such metabolites interact with glutamate receptors in the central nervous system, potentially modulating mechanisms th...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-017-1002-2
更新日期:2017-12-01 00:00:00
abstract::Despite ample evidence linking particular child temperament characteristics to behavior disorders later in life, there is currently a lack of temperament measures that can be used early, easily, and widely for screening purposes. To redress this gap, the current research aimed at developing a very brief scale of child...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-019-01379-5
更新日期:2020-05-01 00:00:00
abstract::According to the International Children's Continence Society (ICCS) guidelines for the treatment of daytime urinary incontinence (DUI) in children and adolescents, the first-line intervention for all types of DUI is standard urotherapy (SU). Despite this recommendation there is still no meta-analysis available on the ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00787-017-1051-6
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:To develop an evidence base for using antipsychotic medications for schizophrenia in children and adolescents. METHOD:Data sources were identified in PsychINFO (1872-2003), MEDLINE (1966-2003), and articles in reference lists. Study selection criteria: (1) treatment with antipsychotics; (2) ages were betwee...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00787-005-0515-2
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:To investigate the current situation of Child and Adolescent Psychiatry (CAP) training in European countries. In addition, current agenda of different organizations in order to harmonize the training across Europe are reported. METHOD:In order to collect data for this descriptive documentation on CAP trainin...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-006-0599-3
更新日期:2006-12-01 00:00:00
abstract::Adolescents hearing non-existent voices may be at risk for psychosis, but the prevalence of voice-hearing (VH) in the general population complicates clinical interpretations. Differentiating between VH with and without distress may aid treatment decisions in psychosis services, but understanding the differences betwee...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-019-01292-x
更新日期:2019-10-01 00:00:00
abstract::Although Attention Deficit Hyperactivity Disorder (ADHD) is recognised to be a familial and heritable disorder, little is known about the broader family characteristics of having a parent with ADHD problems. The main aim of this study was to investigate the relationship between parent ADHD problems, child clinical pre...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-013-0378-x
更新日期:2013-06-01 00:00:00
abstract::Attention Deficit and Hyperactive Disorder (ADHD) and Autism Spectrum Disorders (ASD) are frequent comorbid neurodevelopmental conditions and the overlap between both disorders remains to be delineated. A more complete understanding of the shared genetic and environmental factors is needed. Using a family-based method...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-018-1206-0
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:The present study investigated the relationship between daytime symptomatology and nightmare frequency in school-aged children by eliciting daytime symptoms and nightmare frequency from children directly in addition to questionnaires completed by their parents. METHODS:A sample of 4,834 parents and 4,531 of ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-008-0697-5
更新日期:2009-01-01 00:00:00
abstract::We compared the predictability of the behaviour of hyperactive children with that of aggressive children, combined hyperactive/aggressive children and normal children. Detailed behaviour measurements relating to each child and an experimenter were recorded during playroom session. Predictability was expressed in infor...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/BF00571673
更新日期:1996-09-01 00:00:00
abstract::Nine people from the high functioning end of the autistic spectrum and eight non-handicapped controls matched on verbal IQ were given two tests of second-order false belief understanding. On the basis of previous research, it was hypothesised that the subjects with autism used different mechanisms to process mental st...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/BF00538988
更新日期:1997-09-01 00:00:00
abstract::The main behavioral characteristic of subthreshold depression that is observed in adolescents is the low frequency of exposure to environmental rewards. Therefore, it was considered that a simple intervention conducted in short sessions, focusing on increasing access to positively reinforcing activities, would be effi...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00787-016-0842-5
更新日期:2016-11-01 00:00:00
abstract::Dopamine genes are candidate genes for dyslexia in the light of the well-known comorbidity between dyslexia and ADHD. Within-family association and linkage disequilibrium were tested between four genetic markers at DRD4, DRD3, DRD2, and DAT loci, and dyslexia, in a sample of 130 Italian dyslexic children, 16.9% of who...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-003-0332-4
更新日期:2003-08-01 00:00:00
abstract::Parent-mediated intervention is widely used for pre-schoolers with autism spectrum disorder (ASD). Previous studies indicate small-to-moderate effects on social communication skills, but with a wide heterogeneity that requires further research. In this randomized controlled trial (RCT), cooperative parent-mediated the...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00787-019-01395-5
更新日期:2020-07-01 00:00:00
abstract::Adolescence is a vulnerable period for psychological distress. This study aimed to comprehensively investigate the distribution of major stress-causing factors and their correlates in a large population of adolescents. A computerized self-report questionnaire was completed by 291,110 participating adolescents over a 4...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-020-01520-9
更新日期:2020-03-30 00:00:00
abstract::The aim was to study the association between preschool behavioural problems and emotional symptoms in 10- to 12-year-old children. The study was based on the Aarhus Birth cohort, Denmark, and included 1,336 children. Based on the parent-administered preschool behaviour questionnaire (PBQ), we identified three not mutu...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-010-0128-2
更新日期:2010-10-01 00:00:00
abstract::Understanding the developmental course of all health issues associated with preterm birth is important from an individual, clinical and public health point-of-view. Both the number of preterm births and proportion of survivors have increased steadily in recent years. The UK Millennium Cohort Study (n = 18,818) was use...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-016-0872-z
更新日期:2017-01-01 00:00:00