Abstract：
:This study aims at determining serum levels of tryptophan and other metabolites of the kynurenine pathway in children with attention deficit hyperactivity disorder (ADHD) compared to healthy controls. Such metabolites interact with glutamate receptors in the central nervous system, potentially modulating mechanisms that are pivotal in ADHD and thus potentially representing peripheral biomarkers of the disorder. We measured serum levels of tryptophan and some metabolites of the kynurenine pathway in 102 children with ADHD and 62 healthy controls by liquid chromatography-tandem mass spectrometry (LC-MS/MS). As compared to healthy controls, children with ADHD showed a reduction in serum levels of anthranilic acid (-60%), kynurenic acid (-11.2%), and xanthurenic acid (-12.5%). In contrast, serum levels of tryptophan (+11.0%) and kynurenine (+48.6%) were significantly enhanced, and levels of quinolinic acid were unchanged in children with ADHD. In a logistic regression model, the presence of ADHD was predicted by low anthranilic acid and high tryptophan levels. These findings support the involvement of the kynurenine pathway in the pathophysiology of ADHD and suggest that anthranilic acid and tryptophan levels should be investigated as potential peripheral biomarker for ADHD.
journal_name
Eur Child Adolesc Psychiatryjournal_title
European child & adolescent psychiatryauthors
Evangelisti M,De Rossi P,Rabasco J,Donfrancesco R,Lionetto L,Capi M,Sani G,Simmaco M,Nicoletti F,Villa MPdoi
10.1007/s00787-017-1002-2subject
Has Abstractpub_date
2017-12-01 00:00:00pages
1433-1441issue
12eissn
1018-8827issn
1435-165Xpii
10.1007/s00787-017-1002-2journal_volume
26pub_type
杂志文章abstract：:The case history, treatment and follow-up of a family sharing the same delusion are presented in this article. The characteristics of separation-individuation of this pathological condition and its treatment are discussed. ...
journal_title：European child & adolescent psychiatry
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journal_title：European child & adolescent psychiatry
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journal_title：European child & adolescent psychiatry
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