Abstract：
:Alterations in fear learning/generalization are considered to be relevant mechanisms engendering the development of anxiety disorders being the most prevalent mental disorders. Although anxiety disorders almost exclusively have their first onset in childhood and adolescence, etiological research focuses on adult individuals. In this study, we evaluated findings of a recent meta-analysis of genome-wide association studies in adult anxiety disorders with significant associations of four single nucleotide polymorphisms (SNPs) in a large cohort of 347 healthy children (8-12 years) characterized for dimensional anxiety. We investigated the modulation of anxiety parameters by these SNPs in a discriminative fear conditioning and generalization paradigm in the to-date largest sample of children. Results extended findings of the meta-analysis showing a genomic locus on 2p21 to modulate anxious personality traits and arousal ratings. These SNPs might, thus, serve as susceptibility markers for a shared risk across pathological anxiety, presumably mediated by alterations in arousal.
journal_name
Eur Child Adolesc Psychiatryjournal_title
European child & adolescent psychiatryauthors
Reinhard J,Drepper C,Weber H,Schiele MA,Kneer K,Mittermeier A,Frey L,Reif A,Pauli P,Domschke K,Deckert J,Romanos Mdoi
10.1007/s00787-019-01458-7subject
Has Abstractpub_date
2020-09-01 00:00:00pages
1301-1310issue
9eissn
1018-8827issn
1435-165Xpii
10.1007/s00787-019-01458-7journal_volume
29pub_type
杂志文章abstract：:Although major guidelines in the field and current diagnostic criteria clearly demand an assessment of children's attention deficit/hyperactivity disorder (ADHD) symptoms at school, few studies address the fundamental question of which is the best approach for clinicians to get this information from teachers. Three sc...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-013-0466-y
更新日期：2014-06-01 00:00:00
abstract：INTRODUCTION:We present the results of a 42 year long-term follow-up of 44 patients (19 males, 25 females) with childhood-onset schizophrenia (COS, age at onset: 7-14 years) who could be traced for a second follow-up examination 27 years after the first follow-up. METHOD:Data from interviews, clinical records, premorb...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章,评审
doi：10.1007/pl00010687
更新日期：1999-01-01 00:00:00
abstract：:Research consistently chronicles a variety of mental health difficulties that plague institutionally reared children, including attention-deficit/hyperactivity disorder (ADHD), even if not all institutionalized children evince such problems. In seeking to extend work in this area, this research on gene × environment (...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-016-0890-x
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The Strengths and Difficulties Questionnaire (SDQ) is a short assessment instrument which addresses positive and negative behavioural attributes of children and adolescents and generates scores for clinically relevant aspects. Although this brief questionnaire has been widely used in Germany t...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-004-2002-6
更新日期：2004-01-01 00:00:00
abstract：:Despite the fact that juvenile fire involvement is associated with significant injuries and is highly correlated with diverse maladjustment characteristics, firesetting has never been empirically evaluated in Italy. Participants included 567 youth between 11 and 18 years of age. This investigation attempted to address...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-007-0664-6
更新日期：2008-06-01 00:00:00
abstract：:The aim of this study is to investigate whether in addition to established early risk factors other, less studied pre-, peri-, and postnatal influences, like gestational hypertension or neonatal respiratory disorders and infections, may increase a child's risk of developing attention-deficit/hyperactivity disorders (A...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章,多中心研究
doi：10.1007/s00787-017-0966-2
更新日期：2017-08-01 00:00:00
abstract：:Dopamine genes are candidate genes for dyslexia in the light of the well-known comorbidity between dyslexia and ADHD. Within-family association and linkage disequilibrium were tested between four genetic markers at DRD4, DRD3, DRD2, and DAT loci, and dyslexia, in a sample of 130 Italian dyslexic children, 16.9% of who...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-003-0332-4
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章,多中心研究
doi：10.1007/s00787-019-01348-y
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-014-0541-z
更新日期：2015-01-01 00:00:00
abstract：:Callous-unemotional (CU) traits correlate with the severity and prognosis of conduct disorder in youth. The neuropeptide oxytocin (OT) has been linked to prosocial behaviors, including empathy and collaboration with others. This study discusses a possible role for OT in the biology of delinquent behavior. We hypothesi...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-015-0765-6
更新日期：2015-12-01 00:00:00
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-020-01543-2
更新日期：2020-05-07 00:00:00
abstract：:This project describes the dissemination of an evidence-based parenting skills intervention by training social and health workers with little or no mental health background so that they themselves train mothers of children with behavioral problems in impoverished communities in a developing country. The Strengths and ...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-010-0099-3
更新日期：2010-08-01 00:00:00
abstract：:Pediatric body dysmorphic disorder (BDD) is challenging to treat. This study aimed to establish the prevalence of insomnia in youth with BDD and explore its impact on clinical outcomes. Sixty-six children and adolescents with BDD consecutively referred to a specialist clinic completed a range of clinical measures, inc...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-019-01442-1
更新日期：2020-09-01 00:00:00
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-012-0277-6
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-010-0089-5
更新日期：2010-07-01 00:00:00
abstract：:Autonomic activity and respiration were studied in Rett syndrome (RS) and age matched controls. Breathing movements were monitored using a pletysmograph around the chest. Sympathetic activity was monitored by measuring blood pressure (BP) using the Finapres. Cardiac parasympathetic activity was monitored by measuring ...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：OBJECTIVE:The present study investigated the relationship between daytime symptomatology and nightmare frequency in school-aged children by eliciting daytime symptoms and nightmare frequency from children directly in addition to questionnaires completed by their parents. METHODS:A sample of 4,834 parents and 4,531 of ...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-008-0697-5
更新日期：2009-01-01 00:00:00
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章,评审
doi：10.1007/s00787-017-1020-0
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
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journal_title：European child & adolescent psychiatry
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更新日期：2020-07-26 00:00:00
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journal_title：European child & adolescent psychiatry
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abstract：:Service comparison is a policy priority but is not without controversy. This paper aims to investigate the amount of service-level variation in outcomes in child mental health, whether it differed when examining outcomes unadjusted vs. adjusted for expected change over time, and which patient-level characteristics wer...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-016-0939-x
更新日期：2017-06-01 00:00:00
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-016-0886-6
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abstract：:Deficits in motor and imitation abilities are a core finding in autism spectrum disorders (ASD), but impaired motor functions are also found in attention deficit/hyperactivity disorder (ADHD). Given recent theorising about potential aetiological overlap between the two disorders, the present study aimed to assess diff...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/s00787-015-0753-x
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abstract：:Physiological stress is thought to be one way that early adversity may impact children's health. How this occurs may be related to parental factors such as mothers' own stress and parenting behaviour. Hair cortisol offers a novel method for examining long-term physiological stress in mother-child dyads. The current st...
journal_title：European child & adolescent psychiatry
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doi：10.1007/s00787-020-01537-0
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journal_title：European child & adolescent psychiatry
pub_type： 杂志文章,评审
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abstract：:Concentrations of melatonin in overnight and first-voiding urine samples from 10 people with autism, 15 parents, 1 grandparent, 9 sibs without autism, and 10 healthy, unrelated volunteers, were measured by radioimmunoassay. Those with autism had significantly higher melatonin concentrations in the first voiding sample...
journal_title：European child & adolescent psychiatry
pub_type： 杂志文章
doi：10.1007/BF02098862
更新日期：1993-04-01 00:00:00
