Impaired working speed and executive functions as frontal lobe dysfunctions in young first-degree relatives of schizophrenic patients.

Abstract:

:The aim of the investigation was to detect neuropsychological markers, such as sustained and selective attention and executive functions, which contribute to the vulnerability to schizophrenia especially in young persons. Performance was assessed in 32 siblings and children of schizophrenic patients and 32 matched controls using Wisconsin Card Sorting Test, Colour-Word-Interference-Test, Trail Making Test, and d2-Concentration-Test. The first-degree relatives showed certain impairments on all four tests, in particular, slower times on all time-limited tests. These results suggest the need for more time when completing neuropsychological tasks involving selected and focused attention, as well as cognitive flexibility, as a possible indicator of genetic vulnerability to schizophrenia.

authors

Klemm S,Schmidt B,Knappe S,Blanz B

doi

10.1007/s00787-006-0547-2

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

400-8

issue

7

eissn

1018-8827

issn

1435-165X

journal_volume

15

pub_type

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