Abstract:
:Genetic epidemiological studies of Autism Spectrum Disorders (ASDs) based on twin pairs ascertained from the population and thoroughly assessed to obtain a high degree of diagnostic validity are few. All twin pairs aged 3-14 years in the nationwide Danish Twin Registry were approached. A three-step procedure was used. Five items from the "Child Behaviour Checklist" (CBCL) were used in the first screening phase, while screening in the second phase included the "Social and Communication Questionnaire" and the "Autism Spectrum Screening Questionnaire". The final clinical assessment was based on "gold standard" diagnostic research procedures including diagnostic interview, observation and cognitive examination. Classification was based on DSM-IV-TR criteria. The initial sample included 7,296 same-sexed twin pairs and, after two phases of screening and clinical assessment, the final calculations were based on 36 pairs. The probandwise concordance rate for ASD was 95.2% in monozygotic (MZ) twins (n=13 pairs) and 4.3% in dizygotic (DZ) twins (n=23 pairs). The high MZ and low DZ concordance rate support a genetic aetiology to ASDs.
journal_name
Eur Child Adolesc Psychiatryjournal_title
European child & adolescent psychiatryauthors
Nordenbæk C,Jørgensen M,Kyvik KO,Bilenberg Ndoi
10.1007/s00787-013-0419-5subject
Has Abstractpub_date
2014-01-01 00:00:00pages
35-43issue
1eissn
1018-8827issn
1435-165Xjournal_volume
23pub_type
杂志文章abstract::The greater burden of illness in youth with co-occurring attention-deficit/hyperactivity disorder (ADHD) and major depressive disorder (MDD) deserves further investigation, specifically regarding the influence of other psychiatric or medical conditions and the pharmacotherapies prescribed. A retrospective cohort desig...
journal_title:European child & adolescent psychiatry
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journal_title:European child & adolescent psychiatry
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journal_title:European child & adolescent psychiatry
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journal_title:European child & adolescent psychiatry
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journal_title:European child & adolescent psychiatry
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journal_title:European child & adolescent psychiatry
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journal_title:European child & adolescent psychiatry
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journal_title:European child & adolescent psychiatry
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journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
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journal_title:European child & adolescent psychiatry
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journal_title:European child & adolescent psychiatry
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journal_title:European child & adolescent psychiatry
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