No evidence for association and linkage disequilibrium between dyslexia and markers of four dopamine-related genes.

Abstract:

:Dopamine genes are candidate genes for dyslexia in the light of the well-known comorbidity between dyslexia and ADHD. Within-family association and linkage disequilibrium were tested between four genetic markers at DRD4, DRD3, DRD2, and DAT loci, and dyslexia, in a sample of 130 Italian dyslexic children, 16.9% of whom had comorbid ADHD. No evidence of either association or linkage disequilibrium was found, neither in the total sample nor in the comorbid subgroup. Negative results do not support a common genetic basis between these two disorders for these markers.

authors

Marino C,Giorda R,Vanzin L,Molteni M,Lorusso ML,Nobile M,Baschirotto C,Alda M,Battaglia M

doi

10.1007/s00787-003-0332-4

keywords:

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

198-202

issue

4

eissn

1018-8827

issn

1435-165X

journal_volume

12

pub_type

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