当前位置： SCI文献检索 > JOURNAL OF BIOMECHANICS期刊下所有文献 > Unique behavior of dermal cells from regenerative mammal, the African Spiny Mouse, in response to substrate stiffness.

Unique behavior of dermal cells from regenerative mammal, the African Spiny Mouse, in response to substrate stiffness.

Abstract：

:The African Spiny Mouse (Acomys spp.) is a unique outbred mammal capable of full, scar-free skin regeneration. In vivo, we have observed rapid reepithelialization and deposition of normal dermis in Acomys after wounding. Acomys skin also has a lower modulus and lower elastic energy storage than normal lab mice, Mus musculus. To see if the different in vivo mechanical microenvironments retained an effect on dermal cells and contributed to regenerative behavior, we examined isolated keratinocytes in response to physical wounding and fibroblasts in response to varying substrate stiffness. Classic mechanobiology paradigms suggest stiffer substrates will promote myofibroblast activation, but we do not see this in Acomys dermal fibroblasts (DFs). Though Mus DFs increase organization of α-smooth muscle actin (αSMA)-positive stress fibers as substrate stiffness increases, Acomys DFs assemble very few αSMA-positive stress fibers upon changes in substrate stiffness. Acomys DFs generate lower traction forces than Mus DFs on pliable surfaces, and Acomys DFs produce and modify matrix proteins differently than Mus in 2D and 3D culture systems. In contrast to Acomys DFs "relaxed" behavior, we found that freshly isolated Acomys keratinocytes retain the ability to close wounds faster than Mus in an in vitro scratch assay. Taken together, these preliminary observations suggest that Acomys dermal cells retain unique biophysical properties in vitro that may reflect their altered in vivo mechanical microenvironment and may promote scar-free wound healing.

journal_name

J Biomech

journal_title

Journal of biomechanics

authors

Stewart DC,Serrano PN,Rubiano A,Yokosawa R,Sandler J,Mukhtar M,Brant JO,Maden M,Simmons CS

doi

10.1016/j.jbiomech.2018.10.005

subject

Has Abstract

pub_date

2018-11-16 00:00:00

pages

149-154

eissn

0021-9290

issn

1873-2380

pii

S0021-9290(18)30767-X

journal_volume

81

pub_type

杂志文章

相关文献

JOURNAL OF BIOMECHANICS文献大全
  • Index-matched measurements of the effect of cartilaginous rings on tracheobronchial flow.

    abstract：:We present a comparison of the flow characteristics in an idealized smooth trachea model and a second model which has a roughness simulating cartilaginous rings. We use refractive index-matched particle image velocimetry (PIV) to measure the velocity field in a two-generation model of the trachea and main bronchi. The...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2016.03.043

    authors： Bocanegra Evans H,Castillo L

    更新日期：2016-06-14 00:00:00

  • In-vitro results of rapid maxillary expansion on adults compared with finite element simulations.

    abstract：:This study was mainly performed to investigate the effects of high maxillary expansion forces on the skull with fresh and thiel-fixed human skulls. The maxillary suture was not weakened except in one experiment. This study compares the strain measured on the zygomatic process of the skull with the results of a finite ...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2010.02.002

    authors： Boryor A,Hohmann A,Wunderlich A,Geiger M,Kilic F,Sander M,Sander C,Böckers T,Günter Sander F

    更新日期：2010-05-07 00:00:00

  • Does weightlifting increase residual force enhancement?

    abstract：:The force maintained following stretching of an active muscle exceeds the isometric force at the same muscle length. This residual force enhancement (RFE) is different for various muscles. It is currently unknown whether training induces changes in RFE. Weightlifters perform a large number of eccentric contractions du...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2016.05.017

    authors： Siebert T,Kurch D,Blickhan R,Stutzig N

    更新日期：2016-07-05 00:00:00

  • Novel isodamping dynamometer accurately measures plantar flexor function.

    abstract：:Isokinetic dynamometers are the gold standard tools used to assess in vivo joint and muscle function in human subjects, however, the large size and high cost of these devices prevents their widespread use outside of traditonal biomechanics labs. In this study, we developed a mobile dynamometer to allow for field measu...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2020.110015

    authors： Drazan JF,Hullfish TJ,Baxter JR

    更新日期：2020-10-09 00:00:00

  • Nonuniform swelling-induced residual strains in articular cartilage.

    abstract：:Swelling effects in cartilage originate from an interstitial osmotic pressure generated by the presence of negatively charged proteoglycans in the tissue. This swelling pressure gives rise to a non-zero residual strain in the cartilage solid matrix in the absence of externally applied loads. Previous studies have quan...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/s0021-9290(98)00184-5

    authors： Narmoneva DA,Wang JY,Setton LA

    更新日期：1999-04-01 00:00:00

  • A reduction of the saddle vertical force triggers the sit-stand transition in cycling.

    abstract：:The purpose of the study was to establish the link between the saddle vertical force and its determinants in order to establish the strategies that could trigger the sit-stand transition. We hypothesized that the minimum saddle vertical force would be a critical parameter influencing the sit-stand transition during cy...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2015.07.035

    authors： Costes A,Turpin NA,Villeger D,Moretto P,Watier B

    更新日期：2015-09-18 00:00:00

  • Comparison of tendon tensions estimated from two biomechanical models of the thumb.

    abstract：:Despite the paramount function of the thumb in daily life, thumb biomechanical models have been little developed and studied. Moreover, only two studies provided quantitative anthropometric data of tendon moment arms. To investigate thumb tendon tensions, biomechanicians and clinicians have to know the performances an...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2009.03.052

    authors： Vigouroux L,Domalain M,Berton E

    更新日期：2009-08-07 00:00:00

  • A first estimation of prestress in so-called circularly fibered osteonic lamellae.

    abstract：:The existence and role of prestress in the various hierarchical structures of long bone are long standing questions. In this study, the prestress and associated strain that exist in a component of human bone microstructure, circularly fibered osteonic lamella, are estimated. Such estimates allow the formulation of hyp...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/s0021-9290(99)00080-9

    authors： Ascenzi MG

    更新日期：1999-09-01 00:00:00

  • Virtual traumatology of pregnant women: the PRegnant car Occupant Model for Impact Simulations (PROMIS).

    abstract：:This study report documents the development of a finite element (FE) model for analyzing trauma in pregnant women involved in road accidents and help the design of a specific safety device. The model is representative of a 50th percentile pregnant woman at 26 weeks of pregnancy in sitting position. To achieve this, th...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2013.09.013

    authors： Auriault F,Thollon L,Peres J,Delotte J,Kayvantash K,Brunet C,Behr M

    更新日期：2014-01-03 00:00:00

  • Multichannel strain gauge telemetry for orthopaedic implants.

    abstract：:In vivo measurements of the loads and deformations occurring in orthopaedic implants will allow future improvements to be made. This paper describes an extremely small telemetry for long term measurements with three strain gauges and methods for an absolutely safe implant design. Developed for measuring the load at hi...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/0021-9290(88)90009-7

    authors： Bergmann G,Graichen F,Siraky J,Jendrzynski H,Rohlmann A

    更新日期：1988-01-01 00:00:00

  • Matrix mechanical properties of transversalis fascia in inguinal herniation as a model for tissue expansion.

    abstract：:Inguinal herniation represents a common condition requiring surgical intervention. Despite being regarded as a connective tissue disorder of uncertain cause, research has focused predominantly on biochemical changes in the key tissue layer, the transversalis fascia (TF) with little direct analysis of functional tissue...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2008.08.018

    authors： Kureshi A,Vaiude P,Nazhat SN,Petrie A,Brown RA

    更新日期：2008-12-05 00:00:00

  • Comparison of acoustic characteristics predicted by Biot's theory and the modified Biot-Attenborough model in cancellous bone.

    abstract：:Biot's theory and the modified Biot-Attenborough (MBA) model are applied to predict the dependences of acoustic characteristics on frequency and on porosity in cancellous bone. The phase velocities and the attenuation coefficients predicted by both theories are compared with the experimental data of bovine cancellous ...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2004.12.004

    authors： Lee KI,Yoon SW

    更新日期：2006-01-01 00:00:00

  • Hospital bed height influences biomechanics during bed egress: A comparative controlled study of patients with Parkinson disease.

    abstract：:Although a significant proportion of patient falls occur during egress from the hospital bed, the biomechanical adaptations during egress from different bed heights are still largely unknown. The purpose of this study was to evaluate the effect of hospital bed height on natural transition during egress in patients wit...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2020.110116

    authors： Xu H,Li X,Shi Y,An L,Taylor D,Christman M,Morse J,Merryweather A

    更新日期：2021-01-22 00:00:00

  • Ligament fibre recruitment at the human ankle joint complex in passive flexion.

    abstract：:Knowledge of ligament fibre recruitment at the human ankle joint complex is a fundamental prerequisite for analysing mobility and stability. Previous experimental and modelling studies have shown that ankle motion must be guided by fibres within the calcaneofibular and tibiocalcaneal ligaments, which remain approximat...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2004.02.043

    authors： Stagni R,Leardini A,Ensini A

    更新日期：2004-12-01 00:00:00

  • An instrumented, dynamic test for anterior laxity of the ankle joint complex.

    abstract：:Evaluation of anterior laxity of the ankle joint complex is a difficult clinical problem. Currently, the prime determinant for anterolateral ligament function is the subjective manual examination of anterior laxity of the ankle joint complex. An instrumented dynamic test was developed for objective measurement of ante...

    journal_title：Journal of biomechanics

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0021-9290(02)00189-6

    authors： Kerkhoffs GM,Blankevoort L,Schreurs AW,Jaspers JE,van Dijk CN

    更新日期：2002-12-01 00:00:00

  • The knee joint center of rotation is predominantly on the lateral side during normal walking.

    abstract：:The purpose of this study was to test the hypothesis of whether the center of rotation (COR) in the transverse plane of the knee is in the medial side during normal walking in a manner similar to that previously described during non-ambulatory activities. The kinematics for normal knees was obtained from 46 knees duri...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2008.01.013

    authors： Koo S,Andriacchi TP

    更新日期：2008-01-01 00:00:00

  • Apparent mass of the standing human body when using a whole-body vibration training machine: Effect of knee angle and input frequency.

    abstract：:Several studies have investigated the transmission of vibration from the vibrating plate of a whole-body vibration training machine (WBVTM) to different locations on the human body. No known work has investigated the interface force between the vibrating plate of the machine and the human body. This paper investigates...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2018.11.003

    authors： Nawayseh N,Hamdan S

    更新日期：2019-01-03 00:00:00

  • Altered frontal and transverse plane tibiofemoral kinematics and patellofemoral malalignments during downhill gait in patients with mixed knee osteoarthritis.

    abstract：:Patients with knee osteoarthritis often present with signs of mixed tibiofemoral and patellofemoral joint disease. It has been suggested that altered frontal and transverse plane knee joint mechanics play a key role in compartment-specific patterns of knee osteoarthritis, but in-vivo evidence in support of this premis...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2015.05.015

    authors： Farrokhi S,Meholic B,Chuang WN,Gustafson JA,Fitzgerald GK,Tashman S

    更新日期：2015-07-16 00:00:00

  • Variability of tissue mineral density can determine physiological creep of human vertebral cancellous bone.

    abstract：:Creep is a time-dependent viscoelastic deformation observed under a constant prolonged load. It has been indicated that progressive vertebral deformation due to creep may increase the risk of vertebral fracture in the long-term. The objective of this study was to examine the relationships of creep with trabecular arch...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2011.03.025

    authors： Kim DG,Shertok D,Ching Tee B,Yeni YN

    更新日期：2011-06-03 00:00:00

  • The effect of sterilization on the dynamic mechanical properties of paired rabbit cortical bone.

    abstract：:The optimal sterilization method for load bearing allografts remains a clinical concern. Recently, supercritical carbon dioxide (SCCO2) treatments have been shown to be capable of terminally sterilizing a range of bacteria and viruses, while preserving the static mechanical properties of cortical bone. This study eval...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2013.04.006

    authors： Russell N,Rives A,Bertollo N,Pelletier MH,Walsh WR

    更新日期：2013-06-21 00:00:00

  • In vivo determination of normal and anterior cruciate ligament-deficient knee kinematics.

    abstract：:The objective of the current study was to use fluoroscopy to accurately determine the three-dimensional (3D), in vivo, weight-bearing kinematics of 10 normal and five anterior cruciate ligament deficient (ACLD) knees. Patient-specific bone models were derived from computed tomography (CT) data. 3D computer bone models...

    journal_title：Journal of biomechanics

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jbiomech.2004.02.042

    authors： Dennis DA,Mahfouz MR,Komistek RD,Hoff W

    更新日期：2005-02-01 00:00:00

  • Two mathematical models explain the variation in cystometrograms of obstructed urinary bladders.

    abstract：:Overdistension of the urinary bladder, secondary to outlet obstruction, causes cellular changes in the bladder wall, including hypertrophy of the smooth muscle cells, which increase bladder mass. To investigate the effects of increased mass on the cystometrogram (CMG), we have developed two mathematical models. In the...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：

    authors： Damaser MS,Lehman SL

    更新日期：1996-12-01 00:00:00

  • Using directional statistics to test hypotheses regarding rigid body attitude: Comparison to univariate and multivariate Cardan angle tests.

    abstract：:Rigid body attitude and single-joint kinematics are typically expressed using three Cardan angles which represent rotations in anatomical planes. It was recently shown in the Biomechanics literature that Cardan angles inaccurately estimate true mean attitude due to an important mathematical inadequacy: attitude under-...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2020.109976

    authors： Pataky TC,Challis JH

    更新日期：2020-10-09 00:00:00

  • Kinematic evaluation of cruciate-retaining total knee replacement patients during level walking: a comparison with the displacement-controlled ISO standard.

    abstract：:Differences between wear-scar features of simulator-tested and retrieved tibial total knee replacement (TKR) liners have been reported. This disagreement may result from differences between in vivo kinematic profiles and those defined by the International Organization for Standardization (ISO). The purpose of this stu...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2009.06.030

    authors： Ngai V,Wimmer MA

    更新日期：2009-10-16 00:00:00

  • Cervical spine morphology and ligament property variations: A finite element study of their influence on sagittal bending characteristics.

    abstract：:Cervical spine finite element models reported in biomechanical literature usually represent a static morphology. Not considering morphology as a model parameter limits the predictive capabilities for applications in personalized medicine, a growing trend in modern clinical practice. The objective of the study was to i...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2018.12.044

    authors： John JD,Saravana Kumar G,Yoganandan N

    更新日期：2019-03-06 00:00:00

  • Steady flow in a model of the human carotid bifurcation. Part I--flow visualization.

    abstract：:The geometry of a typical adult human carotid bifurcation, complete with the sinus, was established from a study of a large number of angiograms. A rigid model was constructed from glass and investigations were performed under steady flow conditions using flow visualization techniques over a range of upstream Reynolds...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/0021-9290(82)90057-4

    authors： Bharadvaj BK,Mabon RF,Giddens DP

    更新日期：1982-01-01 00:00:00

  • Measurement of whole-body vibration by double-pulsed holography.

    abstract：:A technique for registering vibration and deformation patterns has been adapted for the measurement of whole-body vibration in humans. Double-exposure holographic interferometry produces three dimensional pictures of the body, allowing exact measurement of the subject's movement between the two pulses. In this study a...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/0021-9290(84)90036-8

    authors： Wangenheim M,Holzmann P,Svensson LB

    更新日期：1984-01-01 00:00:00

  • No need for particle tracing: from accumulating fluid properties to novel blood coagulation model in the lattice Boltzmann method.

    abstract：:The accumulation of a fluid property from the standpoint of a particle moving with non-steady fluid flow (i.e., platelet/blood-cell damage index in pulsating blood flow) is a challenged computational problem due to the current need for particle-tracing methods. The method we developed (dubbed VPI) enables the approxim...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2009.11.011

    authors： Moiseyev G,Bar-Yoseph PZ

    更新日期：2010-03-22 00:00:00

  • Equine subchondral bone failure threshold under impact compression applied through articular cartilage.

    abstract：:Subchondral bone microdamage due to high-impact loading is a key factor leading to post-traumatic knee osteoarthritis. A quantified assessment of the mechanical characteristics of subchondral bone at the tissue-level is essential to study the mechanism of impact-induced microdamage. We combined mechanical impact testi...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2016.05.016

    authors： Malekipour F,Oetomo D,Lee PV

    更新日期：2016-07-05 00:00:00

  • External sensory-motor cues while managing unexpected slippages can violate the planar covariation law.

    abstract：:This study was aimed at investigating the intersegmental coordination of six older adults while managing unexpected slippages delivered during steady walking, and wearing an Active Pelvis Orthosis (APO). The APO was setup either to assist volunteers at the hip levels during balance loss or to be transparent. The Plana...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2019.01.003

    authors： Aprigliano F,Monaco V,Micera S

    更新日期：2019-03-06 00:00:00