Abstract：
:The optimal sterilization method for load bearing allografts remains a clinical concern. Recently, supercritical carbon dioxide (SCCO2) treatments have been shown to be capable of terminally sterilizing a range of bacteria and viruses, while preserving the static mechanical properties of cortical bone. This study evaluated the effect of SCCO2 treatment compared with two doses of gamma irradiation, on clinically relevant dynamic mechanical properties of cortical bone. Quasi-static testing was also performed to compare the impairment of treatment. Whole paired adult rabbit humeri were dissected and randomly assigned into either SCCO2 Control, SCCO2 Additive or gamma irradiation at 10 or 25kGy treatment groups. The bones were treated and mechanically tested in three-point bending, with the lefts acting as controls for the treated rights. Maximum load, energy to failure and stiffness were evaluated from static tests. The number of cycles to failure was determined for fatigue at 6-60% of the ultimate load. This study found that SCCO2 treatment with or without additive did not alter static or dynamic mechanical properties. Gamma irradiation had a deleterious dose dependent effect, with statistically significant (p<0.05) reductions in all static mechanical parameters at 25kGy. This effect was increased in fatigue with statistically significant decreases in both the 10 and 25kGy dose groups. This study highlights the expediency of SCCO2 treatment for load bearing bone allograft processing as terminal sterilization can be achieved while maintaining both the quasi-static and dynamic mechanical properties of the graft.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Russell N,Rives A,Bertollo N,Pelletier MH,Walsh WRdoi
10.1016/j.jbiomech.2013.04.006subject
Has Abstractpub_date
2013-06-21 00:00:00pages
1670-5issue
10eissn
0021-9290issn
1873-2380pii
S0021-9290(13)00183-8journal_volume
46pub_type
杂志文章abstract：:A mathematical model of synovial film filtration and synovial gel formation at normal approach of cartilage surfaces in the human hip joint is presented. The biphasic mixture model presented in Part I of this paper [Hlavácek, J. Biomechanics 26, (1993)] for synovial fluid and that of Mow and his collaborators [J. Biom...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(93)90063-k
更新日期：1993-10-01 00:00:00
abstract：:Bone is subjected in vivo to both high amplitude, low frequency strain, incurred by locomotion, and to low amplitude, broad frequency strain. The biological effects of low amplitude, broad frequency strain are poorly understood. To evaluate the effects of low amplitude strains ranging in frequency from 0 to 50 Hz on o...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(02)00245-2
更新日期：2003-01-01 00:00:00
abstract：:Coarctation of the aorta (COA) is an obstruction of the aorta and is usually associated with bicuspid and tricuspid aortic valve stenosis (AS). When COA coexists with AS, the left ventricle (LV) is facing a double hemodynamic load: a valvular load plus a vascular load. The objective of this study was to develop a lump...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2011.08.001
更新日期：2011-11-10 00:00:00
abstract：:Catheter-delivered intravascular probes are widely used in clinical practice to measure coronary arterial velocity and pressure, but the artefactual effect of the probe on the variables being measured is not well characterised. A coronary artery was simulated with a 180 degrees curved tube 3mm in diameter and the effe...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2006.11.004
更新日期：2007-01-01 00:00:00
abstract：:Cultured cells subjected to fluid flow are exposed to mechanical forces and electrokinetic forces. The convective current establishes an electrokinetic force created by the flow-dependent transport of mobile ions in the media over the charged cell surfaces. This current can be expressed as a current density, the curre...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(96)84535-0
更新日期：1996-11-01 00:00:00
abstract：:Muscle fatigue and recovery are complex processes influencing muscle force generation capacity. While fatigue reduces this capacity, recovery acts to restore the unfatigued muscle state. Many factors can potentially affect muscle recovery, and among these may be a task dependency of recovery following an exercise. How...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.11.061
更新日期：2017-01-25 00:00:00
abstract：:Despite recent attention in the literature, anterior cruciate ligament (ACL) injury mechanisms are controversial and incidence rates remain high. One explanation is limited data on in vivo ACL strain during high-risk, dynamic movements. The objective of this study was to quantify ACL strain during jump landing. Marker...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2010.10.028
更新日期：2011-02-03 00:00:00
abstract：:Accurate location of the hip joint center is essential for computation of hip kinematics and kinetics as well as for determination of the moment arms of muscles crossing the hip. The functional method of hip joint center location involves fitting a pelvis-fixed sphere to the path traced by a thigh-fixed point while a ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(01)00052-5
更新日期：2001-07-01 00:00:00
abstract：:The objective of this study is to develop analytical models for simulating driving-point biodynamic responses distributed at the fingers and palm of the hand under vibration along the forearm direction (z(h)-axis). Two different clamp-like model structures are formulated to analyze the distributed responses at the fin...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2006.10.031
更新日期：2007-01-01 00:00:00
abstract：:The objective of the current study was to use fluoroscopy to accurately determine the three-dimensional (3D), in vivo, weight-bearing kinematics of 10 normal and five anterior cruciate ligament deficient (ACLD) knees. Patient-specific bone models were derived from computed tomography (CT) data. 3D computer bone models...
journal_title：Journal of biomechanics
pub_type： 临床试验,杂志文章
doi：10.1016/j.jbiomech.2004.02.042
更新日期：2005-02-01 00:00:00
abstract：:The literature contains many measurements of the fatigue properties of compact bone, but these experimental results have been difficult to interpret and use due to a large amount of apparent scatter: variation in the number of cycles to failure for a given cyclic stress or strain range. Recently Taylor (1998a, Journal...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(99)00112-8
更新日期：1999-11-01 00:00:00
abstract：:One of the main determinants of perfusion distribution within an organ is the structure of its vascular network. Past studies were based on angiography or corrosion casting and lacked quantitative three dimensional, 3D, representation. Based on branching rules and other properties derived from such imaging, 3D vascula...
journal_title：Journal of biomechanics
pub_type： 杂志文章,评审
doi：10.1016/j.jbiomech.2012.11.027
更新日期：2013-01-18 00:00:00
abstract：:Ultrasound imaging has recently been used to distinguish the length changes of muscle fascicles from those of the whole muscle tendon complex during real life movements. The complicated three-dimensional architecture of pennate muscles can however cause heterogeneity in the length changes along the length of a muscle....
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2005.10.035
更新日期：2007-01-01 00:00:00
abstract：:Anterior cruciate ligament (ACL) injury can result in failure to return to pre-injury activity levels and future osteoarthritis predisposition. Single leg hop is used in late rehabilitation to evaluate recovery and inform treatment but biomechanical understanding of this activity is insufficient. This study investigat...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2013.11.046
更新日期：2014-02-07 00:00:00
abstract：:Pre-clinical tests are often performed to screen new implant designs, surgical techniques, and cement formulations. In this work, we developed a technique to simulate the cement-bone morphology found with postmortem retrieved cemented hip replacements. With this technique, a soy wax barrier is created along the endost...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2010.06.029
更新日期：2010-10-19 00:00:00
abstract：:The aim of this study is to investigate the biomechanics for orthodontic tooth movement (OTM) subjected to concurrent single-tooth vibration (50Hz) with conventional orthodontic force application, via a clinical study and computational simulation. Thirteen patients were recruited in the clinical study, which involved ...
journal_title：Journal of biomechanics
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jbiomech.2017.06.012
更新日期：2017-07-26 00:00:00
abstract：:Several studies have investigated the transmission of vibration from the vibrating plate of a whole-body vibration training machine (WBVTM) to different locations on the human body. No known work has investigated the interface force between the vibrating plate of the machine and the human body. This paper investigates...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2018.11.003
更新日期：2019-01-03 00:00:00
abstract：:An apparatus was designed for mechanical compression of cultured articular cartilage explants with acylindrical plain-ended loading head (diameter 2-5 mm) driven by a stepping motor. A load cell under the culture dish was applied for feedback regulation utilizing a microprocessor-based control unit. The operating prog...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(89)90232-7
更新日期：1989-01-01 00:00:00
abstract：:This study reports for the first time an estimation of the internal net joint forces and torques on adults' lower limbs and pelvis when walking in shallow water, taking into account the drag forces generated by the movement of their bodies in the water and the equivalent data when they walk on land. A force plate and ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2011.01.017
更新日期：2011-04-07 00:00:00
abstract：:Tripping over obstacles is the most frequently mentioned causes of falls. Thus, this study was performed to test the hypotheses that when crossing obstacles, toe-obstacle clearance and the three-dimensional motions and moments at the hip, knee, and ankle of the trailing limb (limb crossing the obstacle last) increase ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(96)00161-3
更新日期：1997-04-01 00:00:00
abstract：:Moment and work of the human calf muscles in level walking were determined by means of an EMG to force processor, based on a muscle analogue (Hof and Van den Berg (1981) J. Biomechanics, 14, 747-758, 759-770, 771-785, 787-792). Nine subjects (four women, five men) walked on a level treadmill at speeds between 0.5 and ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(83)90067-2
更新日期：1983-01-01 00:00:00
abstract：:Pulsatile flow in abdominal aortic aneurysm (AAA) models has been examined in order to understand the hemodynamics that may contribute to growth of an AAA. The model studies were conducted by experiments (flow visualization and laser Doppler velocimetry) and by numerical simulation using physiologically realistic rest...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(99)00134-7
更新日期：1999-12-01 00:00:00
abstract：:This paper describes the process used to generate lower limb kinematics during single limb stance phase of gait, using musculoskeletal modelling, muscle driven forward simulation and gradient based optimisation techniques (including design of experiment techniques). Initial inputs to the forward simulation process wer...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(01)00240-8
更新日期：2002-05-01 00:00:00
abstract：:The goal of the present study was to assess the effects of age and sex on trunk motor control. Fifty healthy adults (aged between 19 and 67 years, 28 males) participated in this study. Trunk motor control was assessed using force-controlled perturbations directly applied to the trunk. Admittance (inverse of lumped int...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2020.109607
更新日期：2020-03-26 00:00:00
abstract：:Individual differences in bone mass distribution at the proximal femur may be determined by daily weight-bearing physical activity (PA) since bone self-adapts according to the mechanical loads that is submitted. The aim of this study was to analyse computationally the effect of different weight-bearing PA types in the...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2013.06.031
更新日期：2013-09-03 00:00:00
abstract：:Intersegmental forces and moments (i.e. resultant free body forces and moments computed at the joint centers) were studied in canine hindlimbs before and after cemented total hip replacement (THR). Five large, adult, mixed-breed dogs were selected. Their gait was recorded (while leash-walked) before surgery using high...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(91)90028-l
更新日期：1991-01-01 00:00:00
abstract：:Despite the paramount function of the thumb in daily life, thumb biomechanical models have been little developed and studied. Moreover, only two studies provided quantitative anthropometric data of tendon moment arms. To investigate thumb tendon tensions, biomechanicians and clinicians have to know the performances an...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2009.03.052
更新日期：2009-08-07 00:00:00
abstract：:Gait analysis is a quantitative, non-invasive technique that can be used to investigate functional changes in animal models of musculoskeletal disease. Changes in ground reaction forces following injury have been observed that coincide with differences in tissue mechanical and histological properties during healing. H...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.12.027
更新日期：2016-02-08 00:00:00
abstract：:Radioembolization, which consist of the implantation of radioactive microspheres via intra-arterially placed microcatheter, is a safe and effective treatment for liver cancer. Nevertheless, radioembolization-related complications and side effects may arise, which are an active area of ongoing research. The catheter de...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.09.035
更新日期：2016-11-07 00:00:00
abstract：:The purpose of this study was to apply the Floating Axis analysis technique to the elbow joint, and to verify its ability to quantify clinically relevant radiohumeral translation in vitro using an electromagnetic tracking device. Of particular interest was the ability to quantify changes in anterior-posterior radial h...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(03)00103-9
更新日期：2003-08-01 00:00:00
